Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects

by George C. Tsokos MD (Editor)

Overview

This completely updated and expanded 2nd edition of Systemic Lupus Erythematosus, A Manual includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter is short and is presented critically with selected references, which should be valuable to a wider audience. This book combines basic with clinical science to help internists and specialists in the diagnosis and management of patients with SLE. It is a quick referral for people in the pharmaceutical industry in their efforts to bring much-needed drugs. It provides all the needed information to basic researchers old and new alike, who wish to enter the field of lupus and systemic autoimmunity in general. - Focused state-of-the-art chapters prepared by top-notch experts in the field - Latest understanding of cellular, molecular, biochemical aspects of disease pathogenesis - Advanced aspects of genetic, microbiome, environmental, hormonal, and immunological contribution to the expression of the disease - Current understanding of clinical features of the disease - Recent efforts to develop new treatments

Product Details

ISBN-13:	9780128145524
Publisher:	Elsevier Science & Technology Books
Publication date:	04/07/2020
Sold by:	Barnes & Noble
Format:	eBook
Pages:	694
File size:	37 MB
Note:	This product may take a few minutes to download.

About the Author

George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.

Table of Contents

Part I - Epidemiology and diagnosis1. History of systemic lupus erythematosus with an emphasis on certain recent major issuesShu Man Fu and Felicia Gaskin2. The patientDonald E. Thomas, Jr.3. A plea of a young patient to the lupus expertsBrianna Fitzpatrick4. EpidemiologyManuel F. Ugarte-Gil, Guillermo J. Pons-Estel and Graciela S. Alarcón5. Measuring disease activityJoan T. Merrill6. Disease development and outcomeMary Mahieu, Dafna Gladman and Rosalind Ramsey-Goldman7. Socioeconomic aspects of SLETitilola Falasinnu and Julia F. Simard8. Biomarkers in systemic lupus erythematosusStacy P. Ardoin and Wael N. JarjourPart II - Pathogenesis9. Overview of the pathogenesis of systemic lupus erythematosusAntonio La Cava10. System lupus erythematosus and the environmentSoad Haj Yahia and Nancy Agmon-Levin11. Genes and genetics in human SLEMara L. Lennard Richard and Betty P. Tsao12. Monogenic lupusMindy S. Lo13. HormonesTakayuki Katsuyama and Vaishali R. Moulton14. Clinical aspects of the complement system in systemic lupus erythematosusJohn P. Atkinson, M. Kathryn Liszewski and C. Yung Yu15. T cellsFlorencia Rosetti and José C. Crispín16. B cells in SLEAndreia C. Lino and Thomas Dörner17. Neutrophils in systemic lupus erythematosusAmr H. Sawalha18. The role of dendritic cells in systemic lupus erythematosusManon Charrier, Christophe Richez, Estibaliz Lazaro, Vanja Sisirak and Patrick Blanco19. CytokinesTakayuki Katsuyama and Vaishali R. Moulton20. RNA/DNA sensing in SLE—Toll-like receptors and beyondCaroline A. Jefferies and Amir Sharabi21. The role of interferons in systemic lupus erythematosusRuth Fernandez-Ruiz and Timothy Niewold22. Fcγ receptors in autoimmunity and endorgan damageT. Ernandez, K. Okubo, G. Saggu and T.N. Mayadas23. Apoptosis, autophagy, and necrosisRoberto Caricchio24. Infections in early systemic lupus erythematosus pathogenesisRebecka Bourn, Samantha Slight-Webb and Judith A. James25. Microbiota influences on systemic lupus erythematosus and Sjögren's syndromeTeri M. Greiling, Silvio Manfredo Vieira and Martin A. Kriegel26. Origin of autoantibodiesWestley H. Reeves, Shuhong Han and Haoyang Zhuang27. Anti-DNA antibodiesSusan Malkiel, Yemil Atisha-Fregoso and Betty Diamond28. Antihistone and antispliceosome antibodiesMinoru Satoh, Marvin J. Fritzler and Edward K.L. Chan29. Immune complexes in systemic lupus erythematosusKeiju Hiromura and Masaomi Nangaku30. MicroRNA in systemic lupus erythematosusBo Qu, Xiaoyue Jiang and Nan Shen31. Metabolic control of lupus pathogenesis: central role for activation of the mechanistic target of rapamycinAndras Perl32. EpigeneticsChristian M. Hedrich33. What do mouse models teach us about human SLE?Ziaur S.M. Raman and Chandra Mohan34. Genes and genetics of murine systemic lupus erythematosusDwight H. Kono and Argyrios N. TheofilopoulosPart III - Mechanisms of tissue damage35. Mechanisms of renal damage in systemic lupus erythematosusShu Man Fu, Sun-Sang J. Sung, Hongyang Wang, Zhenhuan Zhao and Felicia Gaskin36. Mechanisms of vascular damage in systemic lupus erythematosusSarfaraz A. Hasni and Mariana J. Kaplan37. The mechanism of skin damageXin Huang, Haijing Wu, Christopher Chang and Qianjin Lu38. Pathogenesis of tissue injury in the brain in patients with systemic lupus erythematosusDavid HuntPart IV - Clinical aspects of the disease39. Constitutional symptoms and fatigue in systemic lupus erythematosusSyahrul Sazliyana Shaharir and Caroline Gordon40. The musculoskeletal system in SLEMaria-Louise Barilla-LaBarca, Diane Horowitz, Galina Marder and Richard Furie41. Cutaneous lupus erythematosusAnnegret Kuhn, Aysche Landmann and Gisela Bonsmann42. The clinical evaluation of kidney disease in systemic lupus erythematosusBrad H. Rovin, Isabelle Ayoub and Swati Arora43. The pathology of lupus nephritisIsaac Ely Stillman44. Cardiovascular disease in systemic lupus erythematosus: an updateStephanie Saeli, Tanmayee Bichile, Payal Thakkar and Susan Manzi45.

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From the Publisher

Presents each topic on Systemic Lupus Erythematosus in a critical, easily accessible manner