Systems Biology and Biotechnology of Escherichia coli / Edition 1

Paperback (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $190.73
Usually ships in 1-2 business days
(Save 26%)
Other sellers (Paperback)
  • All (6) from $190.73   
  • New (5) from $190.73   
  • Used (1) from $333.13   


Systems biology and Biotechnology of Escherichia coli Systems biology is changing the way biological systems are studied by allowing us to examine the cell and organism as a whole. Systems biotechnology allows optimal design and development of upstream to downstream bioprocesses by taking a systems-approach. Escherichia coli has been a model organism for almost all biological and biotechnological studies. This book brings together for the first time the state-of-the-art reviews by the world-leading experts on systems biology and biotechnological applications of E. coli. The topics covered includegenomics and functional genomics, resources for systems biology, network analysis, genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli. This book provides readers with guidance on how a complex biological system can be studied using E. coli as a model organism. It also presents how to perform synthetic biology and systems metabolic engineering studies on E. coli with successful examples, the approaches of which can be extended to other organisms.

This book will be a complete resource for anyone interested in systems biology and biotechnology.

Read More Show Less

Editorial Reviews

From the Publisher
"This is a very interesting and powerful collection of chapters covering a wide spectrum of systems biology frontiers in E. coli and written by recognized leaders in the field..... a must have publication for years to come"

Professor Eleftherios Terry Papoutsakis, University of Delaware, U.S.A.

Read More Show Less

Product Details

  • ISBN-13: 9789048181186
  • Publisher: Springer Netherlands
  • Publication date: 12/8/2010
  • Edition description: Softcover reprint of hardcover 1st ed. 2009
  • Edition number: 1
  • Pages: 462
  • Product dimensions: 0.98 (w) x 6.14 (h) x 9.21 (d)

Table of Contents

1 Biological Features and Biotechnological Applications of Escherichia coli B: 'Is B for better?!'; 2 Escherichia coli Genome Engineering and Minimization for the Construction of a Bioengine; 3 Multi-omics Data-driven Systems Biology of E. coli; 4 A Medium-Throughput Structural Proteomics Approach Applied to the Genome of E. coli; 5 Resources for Escherichia coli Systems Biology; 6 The Multiple Scientific Disciplines Served by EcoCyc; 7 Analysis of E. coli Network; 8 Sensory Transduction Network of E. coli; 9 Genome-Scale Reconstruction, Modeling, and Simulation of E. coli’s Metabolic Network; 10 Kinetic Modeling of E.coli Enzymes: Integration of in vitro Experimental Data; 11 Dynamic Modeling of the Central Metabolism of E. coli – Linking Metabolite and Regulatory Networks; 12 Genome-scale Models and the Genetic Basis for E. coli Adaptation; 13 Organisation of Complex Escherichia coli Promoters; 14 Plasmid Regulation and Systems-Level Effects on Escherichia coli Metabolism; 15 Systems-level analysis of protein quality in inclusion body-forming Escherichia coli cells; 16 Mechanistic Challenges and Engineering Applications of Protein Export in E. coli; 17 Engineering E. coli Central Metabolism for Enhanced Primary Metabolite Production; 18 Glucose and Acetate Metabolism in E. coli - System Level Analysis and Biotechnological Applications in Protein Production Processes; 19 Performance Characteristics for Sensors and Circuits Used to Program E.coli; 20 Systems Metabolic Engineering of E. coli; Index

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)