Systems Biology Approaches For Studying Transcriptional Regulation, Metabolic Control And Microbial Growth.

Paperback (Print)
Not Available on

More About This Textbook


It is essential to understand the biology at the system level since an organism can be viewed as a network of interactions among genes, proteins and biochemical reactions which give rise to life. This work focuses on developing systems biology approaches, which advocate in system-level understanding, for studying transcriptional regulation, metabolic control, and the microbial competition for growth. In studying transcriptional regulation, Network Component Analysis (NCA) was developed to determine the activities and key target genes of transcription factors (TFs) from gene expression and TF-gene interaction information. The TF activity information derived from NCA would be particularly useful for looking at the effects of drugs or environmental switch. The theoretical and numerical issues of the method were discussed in this work. The approach was applied for identifying the TFs and signaling pathways regulated by PTEN, a tumor suppressor protein, in different human cancers and animal models. Besides studying transcription regulation, this work also focuses on modeling the metabolic network, which will in turn help to identify the enzymes controlling the metabolic flux. Complete modeling of metabolic networks is often a challenge because of the lack of kinetics. As a step towards this goal, the ensemble modeling approach was developed to build an ensemble of dynamic models reach the same steady state. This ensemble allowed for the examination of possible phenotypes of the network upon perturbations, such as changes in enzyme expression levels, and identification of the rate controlling hotspots in several metabolic systems. Finally this work seeks to determine the underlying principles of microbial competition for growth. The least action principle and its Euler-Lagrangian theorem were used for exploring the dynamics of microbial growth, and derived a conserved quantity, named bio-Hamiltonian, involving biological activities. It was shown that through competition, microbes would be selected to take the least "action" in growth by stabilizing proteins and by achieving a balanced growth for intracellular components.
Read More Show Less

Product Details

  • ISBN-13: 9781243605481
  • Publisher: BiblioLabsII
  • Publication date: 9/4/2011
  • Pages: 156
  • Product dimensions: 7.44 (w) x 9.69 (h) x 0.33 (d)

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)