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Doody's Review ServiceReviewer: Jed N. Lampe, Ph.D.(University of Kansas Medical Center)
Description: In this book, the authors attempt to demonstrate the applicability of systems biology — the discipline of assimilating multiple sources of biological knowledge into a congruent whole using algorithms borrowed from mathematics and engineering — to drug discovery and development. They provide many useful examples with clear explanations.
Purpose: The purpose is to demonstrate the utility of applying a systems biology approach to drug discovery and development, in hopes of accelerating the rate of new drugs coming to market. These are indeed worthy objectives and the authors fill an urgent need with this book.
Audience: It is written primarily for pharmaceutical scientists currently engaged in the drug discovery and development process, although students and academics will also find it useful. The authors both have longstanding track records of accomplishments in the pharmaceutical industry, which clearly comes through in the book.
Features: The authors thoughtfully and methodically lay out the basic approach of systems biology as applied to drug discovery and development and provide several excellent examples of the utility of such an approach from lead identification, to PK/PD studies, to personalized medicine. In particular, the chapters on PK/PD modeling during discovery and early development and simulating clinical trials provide a detailed and through theoretical understanding of the modeling parameters that any investigator would need before analyzing data with one of the popular software packages, such as SimCyp.
Assessment: In short, this is an indispensable tool for both experienced and early stage investigators and others to understand the current and future impact of systems biology on the drug discovery and development process.