T Cell Activation

T Cell Activation

by Jennifer E. Smith-Garvin, Gary A. Koretzky, Martha S. Jordan
     
 
2009 marked the 25th anniversary of the first Annual Review of Immunology article to describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we begin with a brief introduction outlining the chronology of the earliest studies that established the basic paradigm for how the engaged TCR transduces its signals. This review continues

Overview

2009 marked the 25th anniversary of the first Annual Review of Immunology article to describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we begin with a brief introduction outlining the chronology of the earliest studies that established the basic paradigm for how the engaged TCR transduces its signals. This review continues with a description of the current state of our understanding of TCR signaling, as well as a summary of recent findings examining other key aspects of T cell activation, including cross talk between the TCR and integrins, the role of costimulatory molecules, and how signals may negatively regulate T cell function.

Product Details

ISBN-13:
2940013207523
Publisher:
Annual Reviews
Publication date:
10/24/2011
Series:
Annual Review of Immunology , #27
Sold by:
Barnes & Noble
Format:
NOOK Book
Pages:
28
File size:
6 MB

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