T Cell Trafficking in Allergic Asthma: The Ins and Outs

T Cell Trafficking in Allergic Asthma: The Ins and Outs

by Benjamin D. Medoff, Seddon Y. Thomas, Andrew D. Luster
     
 
T cells are critical mediators of the allergic airway inflammation seen in asthma. Pathogenic allergen-specific T cells are generated in regional lymph nodes and are then recruited into the airway by chemoattractants produced by the asthmatic lung. These recruited effector T cells and their products then mediate the cardinal features of asthma: airway eosinophilia,

Overview

T cells are critical mediators of the allergic airway inflammation seen in asthma. Pathogenic allergen-specific T cells are generated in regional lymph nodes and are then recruited into the airway by chemoattractants produced by the asthmatic lung. These recruited effector T cells and their products then mediate the cardinal features of asthma: airway eosinophilia, mucus hypersecretion, and airway hyperreactivity. There has been considerable progress in delineating the molecular mechanisms that control T cell trafficking into peripheral tissue, including the asthmatic lung. In this review, we summarize these advances and formulate them into a working model that proposes that T cell trafficking into and out of the allergic lung is controlled by several discrete regulatory pathways that involve the collaboration of innate and acquired immune cells.

Product Details

ISBN-13:
2940013246843
Publisher:
Annual Reviews
Publication date:
10/24/2011
Series:
Annual Review of Immunology , #26
Sold by:
Barnes & Noble
Format:
NOOK Book
Pages:
27
File size:
6 MB

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