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T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses
     

T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses

5.0 1
by Cecile King
 
T cell help for antibody production is a fundamental aspect of immune responses. Only recently has a better understanding of the cellular and molecular mechanisms for T cell help emerged. A subset of T cells, termed T follicular helper cells (TFH cells), provides a helper function to B cells and represents one of the most numerous and important subsets of effector T

Overview

T cell help for antibody production is a fundamental aspect of immune responses. Only recently has a better understanding of the cellular and molecular mechanisms for T cell help emerged. A subset of T cells, termed T follicular helper cells (TFH cells), provides a helper function to B cells and represents one of the most numerous and important subsets of effector T cells in lymphoid tissues. TFH cells are distinguishable from Th1 and Th2 cells by several criteria, including chemokine receptor expression (CXCR5), location/migration (B cell follicles), and function (B cell help). Central to the function of CD4+ T cells is IL-21, a “helper” cytokine produced by TFH cells that potently stimulates the differentiation of B cells into Ab-forming cells through IL-21R. Consequently, dysregulation of TFH cell function, and over- or under-expression of TFH cell–associated molecules such as ICOS or IL-21, most likely contributes to the pathogenesis of certain autoimmune diseases or immunodeficiencies.

Product Details

BN ID:
2940013247208
Publisher:
Annual Reviews
Publication date:
10/25/2011
Series:
Annual Review of Immunology , #26
Sold by:
Barnes & Noble
Format:
NOOK Book
Pages:
25
File size:
6 MB

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T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses 5 out of 5 based on 0 ratings. 1 reviews.
Anonymous More than 1 year ago
*she cries* I CAN'T BE IMMORTAL! *there is a knife in her leg*