Targeted Cancer Therapy / Edition 1

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*Details the drugs that directly impact the molecular abnormality that characterizes a tumor *Examines personalized medicine based on an understanding of underlying biologic mechanisms *Covers new emerging technologies in target identification, drug discovery, molecular markers, and imaging, which are rapidly changing the face of cancer *Looks at how to design drug combinations that can overcome drug resistance Emerging technologies in target identification, drug discovery, molecular markers, and imaging are rapidly changing the face of cancer. Targeted Cancer Therapy provides a foundation of knowledge in targeted cancer therapeutics. The treatment of cancer is increasingly being individualized, based on an understanding of underlying biologic mechanisms. Poised to change the landscape in oncology, Targeted Cancer Therapy provides a state-of-the-art overview. Targeted Cancer Therapy is valuable to practicing and academic physicians, fellows, residents and students, as well as basic scientists, interested in the cancer field. Written for: Practicing and academic physicians, fellows, residents and students, and basic scientists interested in the cancer field

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Editorial Reviews

From the Publisher
From the reviews:

“Targeted Cancer Therapy provides an overview of recent advancements in therapy deriving from the implementation of new therapeutic agents. … this book represents a useful and stimulating publication. … the book has a scientific and cultural appeal for many other professionals interacting with patients with neoplastic disease. … we also suggest this volume to all students who want to grow into becoming protagonists in the new era of molecular medicine.” (Luigi Mansi and Andrea Vaccaro, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, 2012)

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Product Details

  • ISBN-13: 9781603274234
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 4/28/2008
  • Series: Current Clinical Oncology Series
  • Edition description: 2008
  • Edition number: 1
  • Pages: 446
  • Product dimensions: 6.90 (w) x 10.10 (h) x 1.20 (d)

Table of Contents

Preface vii

Contributors xi

1 Perspectives: Bench to Bedside and Back Jennifer Wheler Razelle Kurzrock 1

2 Targeted Therapy in Acute Myelogenous Leukemia Elihu Estey 21

3 Targeted Therapy in Breast Cancer Barbara S. Craft Stacy Moulder 43

4 Targeted Therapy in Chronic Lymphocytic Leukemia Apostolia-Maria Tsimberidou Michael J. Keating 61

5 Targeted Therapy in Chronic Myeloid Leukemia Elias Jabbour Jorge Cortes Hagop Kantarjian 87

6 Targeted Therapy in Colorectal Cancer Scott Kopetz 101

7 Targeted Therapy in Non-Small Cell Lung Cancer David J. Stewart 125

8 Targeted Therapy in Lymphoma Amanda Wedgwood Anas Younes 157

9 Targeted Therapy in Melanoma Michael Davies Sunil Patel Kevin B. Kim 183

10 Targeted Therapy in Multiple Myeloma Yuhong Zhou Raymond Alexanian Michael Wang 213

11 Targeted Therapy in Myelodysplasia Syndrome Alfonso Quintás-Cardama Hagop Kantarjian Guillermo Garcia-Manero Jorge Cortes 237

12 Targeted Therapy in Epithelial Ovarian Cancer Maurie Markman 261

13 Targeted Drug Therapy in Pancreatic Cancer Don L. Gibbons Robert A. Wolff Gauri Varadhachary 271

14 Targeted Therapy in Prostate Cancer Amado J. Zurita John F. Ward Jeri Kim 289

15 Targeted Therapy in Renal Cell Carcinoma Eric Jonasch Nizar Tannir 305

16 Targeted Therapy of Sarcoma Joseph Ludwig Jonathan C. Trent 317

17 Targeted and Functional Imaging Vikas Kundra Dawid Schellingerhout Edward F. Jackson 335

18 Combining Targeted Therapies David Hong Lakshmi Chintala 361

19 Drug Development in Cancer Medicine: Challenges for Targeted Approaches Luis H. Camacho 383

20 Toward Personalized Therapy for Cancer Sarah J. Welsh Garth Fowis 411

Index 427

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