Targeted Molecular Imaging in Oncology / Edition 1

Targeted Molecular Imaging in Oncology / Edition 1

by E. Edmund Kim, T.P. Haynie, David J. Yang
     
 

ISBN-10: 0387950281

ISBN-13: 9780387950280

Pub. Date: 11/29/2000

Publisher: Springer New York

Cancer cells dedifferentiate with respect to cell function; their vascularity is more leaky, but perfusion is heterogenerously reduced, and interstitial fluid pressure is high, severely retarding delivery of agents from the blood. Targeted imaging is designed to produce a detectable difference between tissue that is visualized with single photon and positron

…  See more details below

Overview

Cancer cells dedifferentiate with respect to cell function; their vascularity is more leaky, but perfusion is heterogenerously reduced, and interstitial fluid pressure is high, severely retarding delivery of agents from the blood. Targeted imaging is designed to produce a detectable difference between tissue that is visualized with single photon and positron emission tomography, magnetic resonance imaging, computed tomography, or ultrasonography. This book uniquely reports strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. This book also descibes updated information about the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

Read More

Product Details

ISBN-13:
9780387950280
Publisher:
Springer New York
Publication date:
11/29/2000
Edition description:
2001
Pages:
290
Product dimensions:
10.00(w) x 7.00(h) x 0.75(d)

Table of Contents

Foreword
Preface
Acknowledgments
Contributors
1Principles of Basic Sciences Related to Cancer1
2Imaging Strategies and Perspectives in Oncology14
3Principles of Single Photon Emission Computed Tomography and Positron Emission Tomography19
4Principles of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy30
5Radiopharmaceuticals for Tumor-Targeted Imaging: Overview62
6Antibodies for Targeted Imaging: Properties and Radiolabeling83
7Radioimmunodetection of Cancer88
8Peptide Receptor Imaging102
9Polymer-Based Compounds for Targeted Imaging111
10Targeted Single Photon Emission Computed Tomography in Oncology121
11Targeted Positron Emission Tomography in Oncology134
12Targeted Magnetic Resonance Imaging Contrast Agents155
13Magnetic Resonance Characteristics of Tumors164
14Targeted Imaging of Lymph Nodes172
15Computed Tomography and Ultrasound Contrast Agents179
16Imaging of Anticancer Drugs for Therapeutic Response and Prognosis185
17Imaging of Angiogenesis200
18Imaging of Apoptosis and Hypoxia215
19Imaging of Signal Transduction and Antisense Imaging229
20Imaging of Gene Delivery and Expression245
21Optical Imaging and In Vivo Microscope260
Index273

Read More

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >