Targeted Molecular Imaging in Oncology / Edition 1

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Cancer cells dedifferentiate with respect to cell function; their vascularity is more leaky, but perfusion is heterogenerously reduced, and interstitial fluid pressure is high, severely retarding delivery of agents from the blood. Targeted imaging is designed to produce a detectable difference between tissue that is visualized with single photon and positron emission tomography, magnetic resonance imaging, computed tomography, or ultrasonography. This book uniquely reports strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. This book also descibes updated information about the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

The book contains black-and-white illustrations.

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Product Details

  • ISBN-13: 9780387950280
  • Publisher: Springer New York
  • Publication date: 11/29/2000
  • Edition description: 2001
  • Edition number: 1
  • Pages: 290
  • Product dimensions: 10.00 (w) x 7.00 (h) x 0.75 (d)

Table of Contents

1 Principles of Basic Sciences Related to Cancer 1
2 Imaging Strategies and Perspectives in Oncology 14
3 Principles of Single Photon Emission Computed Tomography and Positron Emission Tomography 19
4 Principles of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy 30
5 Radiopharmaceuticals for Tumor-Targeted Imaging: Overview 62
6 Antibodies for Targeted Imaging: Properties and Radiolabeling 83
7 Radioimmunodetection of Cancer 88
8 Peptide Receptor Imaging 102
9 Polymer-Based Compounds for Targeted Imaging 111
10 Targeted Single Photon Emission Computed Tomography in Oncology 121
11 Targeted Positron Emission Tomography in Oncology 134
12 Targeted Magnetic Resonance Imaging Contrast Agents 155
13 Magnetic Resonance Characteristics of Tumors 164
14 Targeted Imaging of Lymph Nodes 172
15 Computed Tomography and Ultrasound Contrast Agents 179
16 Imaging of Anticancer Drugs for Therapeutic Response and Prognosis 185
17 Imaging of Angiogenesis 200
18 Imaging of Apoptosis and Hypoxia 215
19 Imaging of Signal Transduction and Antisense Imaging 229
20 Imaging of Gene Delivery and Expression 245
21 Optical Imaging and In Vivo Microscope 260
Index 273
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