Targeted Therapies: Mechanisms of Resistance

by Daniel Gioeli (Editor)

Overview

This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included.

Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

Product Details

ISBN-13:	9781607614777
Publisher:	Springer-Verlag New York, LLC
Publication date:	06/29/2011
Series:	Molecular and Translational Medicine
Edition description:	2011
Pages:	202
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

1 Resistance to Targeted Therapies As a Result of Mutation(s) in the Target Alexis B. Cortot Pasi A. Jänne 1

2 The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies Darnel Gioeli 33

3 Cancer Signaling Network Analysis by Quantitative Mass Spectrometry Jason R. Neil Forest M. White 55

4 Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications Julia D. Wulfkuhle Menawar Khalil Joseph C. Watson Lance A. Liotta Emanuel F. Petricoin III 77

5 Using Phosphoflow™ to Study Signaling Events of Subpopulations Resistant to Current Therapies Omar D. Perez 95

6 Mathematical and Computational Models in Cancer Sudhir Chowbina Kevin A. Janes Shayn M. Peirce Jason A. Papin 113

7 Somatic Evolution of Acquired Drug Resistance in Cancer John W. Pepper 127

8 Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer Edward Gunther 135

9 microRNA: A Potential Therapy Able to Target Multiple Cancer Pathways Benjamin Kefas Benjamin W. Purow 155

10 Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance Yun Dai steven Grant 171

Index 197

Editorial Reviews

From the reviews:

“This is an important resource, providing a mechanistic understanding of the signaling event in cancer for developing effective targeted cancer therapies, as well as computational biology and systems theory. … great value to oncologists and physician-scientists treating patients, and translational scientists … . even students interested in this field will find it useful. … an important book for understanding major mechanisms of resistance to targeted cancer therapeutic agents as well as microRNA as a potential therapy capable of targeting multiple cancer signaling pathways.” (Omer Iqbal, Doody’s Review Service, September, 2011)

“The book provides a well-balanced insight into the topic of drug resistance … . the reader can find a lot of information about the progress and inspiration how to overcome the cancer resistance. The book represents a useful source of knowledge for cell and molecular biologists, geneticists, professionals in bioinformatics, researchers and physicians working in translational oncology.” (J. Sedlak, Neoplasma, Issue 6, November-December, 2012)

From the Publisher