Targeting of Drugs 5: Strategies for Oligonucleotide and Gene Delivery in Therapy

by Gregory Gregoriadis (Editor), Brenda McCormack (Editor)

Overview

Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1995

Product Details

ISBN-13:	9780306455049
Publisher:	Springer US
Publication date:	11/30/1996
Series:	NATO Science Series A: , #290
Edition description:	1996
Pages:	206
Product dimensions:	6.69(w) x 9.61(h) x 0.03(d)

Table of Contents

Gene Therapy for Inherited Genetic Disease: Possibilities and Problems.- Gene Delivery and Therapy: The Case for Cystic Fibrosis.- Immune Responses with Direct Gene Transfer: DNA Vaccines and Implications for Gene Therapy.- Oligonucleotides: Molecular Versions for Optimal Use in Vivo.- Retrovirus Vectors in Gene Therapy: Targeting to Specific Cells.- Adenovirus as Vectors for Gene Therapy.- Receptor-Mediated Gene Delivery with Synthetic Virus-like Particles.- Controllable Gene Therapy: Recent Advances in Non-Viral Gene Delivery.- Genetic Chemistry: Towards Non-Enzymatic Ligation, Sequence-Selective Recognition of DNA, and Self-Assembling Systems for Gene Delivery.- Integrin-Mediated Gene Delivery.- Design, Synthesis, and Cellular Delivery of Antibody Targeted, Radiolabelled Oligonucleotide Conjugates for Cancer Therapy.- Poly(L lysine) Mediated Delivery of Nucleic Acids.- Complement Activation by Polylysine-DNA Complexes.- Nanoparticles as Carriers for Antisense Oligonucleotides.- Efficient Incorporation of Plasmid DNA within Liposomes of Varying Structural Characteristics: Liposomal DNA Integrity and Transfection Efficiency.- pH Sensitive Liposomes as Efficient Carriers for Intracellular Delivery of Oligonucleotides.- Liposomal Delivery of p-Ethoxy Antisense Oligodeoxynucleotides in Chronic Myelogenous Leukemia.- Liposome-Mediated Delivery of Genes and Oligonucleotides for the Treatment of Brain Tumors.- Enzyme Assisted Synthesis of Delivery Systems.- Participants’ Photograph.- Contributors.

Editorial Reviews

The 19 papers explore a variety of systems in terms of their ability to transport nucleic acids to target areas in vitro and in vivo in ways that effectively modify, supplement, correct, or curtail the function of genes in therapy. Among the topics are cystic fibrosis, immune responses with direct gene transfer adenovirus as vectors, integrin-mediated gene delivery, receptor- mediated gene delivery with synthetic virus-like particles, nanoparticles as carriers for antisense oligonucleotides, liposome-mediated delivery for treating brain tumors, and the enzyme assisted synthesis of delivery systems. Annotation c. by Book News, Inc., Portland, Or.

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