Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins / Edition 1

Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins / Edition 1

by Nicholas B. La Thangue
     
 

ISBN-10: 0896039382

ISBN-13: 9780896039384

Pub. Date: 04/03/2002

Publisher: Springer-Verlag New York, LLC

In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The

Overview

In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell involved in chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene control targets, and angiogenesis.

Product Details

ISBN-13:
9780896039384
Publisher:
Springer-Verlag New York, LLC
Publication date:
04/03/2002
Series:
Cancer Drug Discovery and Development Series
Edition description:
2002
Pages:
352
Product dimensions:
6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Prefacev
Contributorsxi
1Cancer Chemotherapy Based on E2F and the Retinoblastoma Pathway1
2Myc Oncoproteins as Targets for Therapeutic Intervention in Tumorigenesis15
3The AP-1 Family of Transcription Factors: Structure, Regulation, and Functional Analysis in Mice29
4Hypoxia-Induced Factor-1 as a Target for Anticancer Therapy53
5Nuclear [beta]-Catenin Signaling as a Target for Anticancer Drug Development71
6Histone Acetyltransferases as Potential Targets for Cancer Therapies101
7Histone Deacetylases123
8Cyclin-Dependent Kinases and Their Small-Molecule Inhibitors in Cancer Therapy145
9Mitogen-Activated Protein Kinase Cascades as Therapeutic Targets in Cancer179
10MDM2 and ARF207
11The Breast Cancer Susceptibility Genes BRCA1 and BRCA2235
12Human Papillomavirus Targets for Therapeutic Intervention249
13Apoptin as an Anticancer Therapy275
14E2F and Cancer Chemotherapy289
15Hypoxic Signaling Pathways as Targets for Anticancer Therapy299
16Androgen Receptor and Estrogen Receptors315
Index341

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