Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins / Edition 1

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Overview

In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell involved in chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene control targets, and angiogenesis.
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Editorial Reviews

From The Critics
Summarizes recent research on therapeutically proven protein targets for cancer drug discovery, particularly new approaches derived from the cancer cell cycle, angiogenesis, and gene and chromatin control targets. The 16 papers identify transcription factor oncoproteins and tumor suppressors, along with other nuclear and chromatin-associated proteins that are central to the phenotype of the tumor cell. Some of the topics are cancer chemotherapy based on E2F and the retinoblastoma pathway, the AP-1 family of transcription factors, cyclin-dependent kinases and their small molecule inhibitors, and human papillomavirus targets for therapeutic intervention. Annotation c. Book News, Inc., Portland, OR (booknews.com)
From the Publisher
'This book will be of interest to drug development professionals and oncology researchers. Specific chapters make good reviews for clinicians interested in emerging therapies and may also be useful for students." - Today's Life Science

"The book is included in the successful series of publications "Cancer Drug Discovery and Development" form Humana Press. It will be of interest both to clinicians and to laboratory cancer researchers, as well as to people who are interested in recent achievements in molecular oncology, which gives new hope for better treatment of caner patients." - Neoplasma

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Product Details

  • ISBN-13: 9780896039384
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 4/3/2002
  • Series: Cancer Drug Discovery and Development Series
  • Edition description: 2002
  • Edition number: 1
  • Pages: 352
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.81 (d)

Table of Contents

Preface
Contributors
1 Cancer Chemotherapy Based on E2F and the Retinoblastoma Pathway 1
2 Myc Oncoproteins as Targets for Therapeutic Intervention in Tumorigenesis 15
3 The AP-1 Family of Transcription Factors: Structure, Regulation, and Functional Analysis in Mice 29
4 Hypoxia-Induced Factor-1 as a Target for Anticancer Therapy 53
5 Nuclear [beta]-Catenin Signaling as a Target for Anticancer Drug Development 71
6 Histone Acetyltrasferases as Potential Targets for Cancer Therapies 101
7 Histone Deacetylases 123
8 Cyclin-Dependent Kinases and Their Small-Molecule Inhibitors in Cancer Therapy 145
9 Mitogen-Activated Protein Kinase Cascades as Therapeutic Targets in Cancer 179
10 MDM2 and ARF 207
11 The Breast Cancer Susceptibility Genes BRCA1 and BRCA2 235
12 Human Papillomavirus Targets for Therapeutic Intervention 249
13 Apoptin as an Anticancer Therapy 275
14 E2F and Cancer Chemotherapy 289
15 Hypoxic Signaling Pathways as Targets for Anticancer Therapy 299
16 Androgen Receptor and Estrogen Receptors 315
Index 341
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