Testosterone and Aging:: Clinical Research Directions

Testosterone and Aging:: Clinical Research Directions

by Catharyn T. Liverman, Dan G. Blazer, Committee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy
     
 

ISBN-10: 0309090636

ISBN-13: 9780309090636

Pub. Date: 02/12/2004

Publisher: National Academies Press

Popular culture often equates testosterone with virility, strength, and the macho male physique. Viewed by some as an “antiaging tonic,†testosterone’s reputation and increased use by men of all ages in the United States have outpaced the scientific evidence about its potential benefits and risks. In particular

Overview

Popular culture often equates testosterone with virility, strength, and the macho male physique. Viewed by some as an “antiaging tonic,†testosterone’s reputation and increased use by men of all ages in the United States have outpaced the scientific evidence about its potential benefits and risks. In particular there has been growing concern about an increase in the number of middle-aged and older men using testosterone and the lack of scientific data on the effect it may have on aging males. Studies of testosterone replacement therapy in older men have generally been of short duration, involving small numbers of participants and often lacking adequate controls. Testosterone and Aging weighs the options of future research directions, examines the risks and benefits of testosterone replacement therapy, assesses the potential public health impact of such therapy in the United States, and considers ethical issues related to the conduct of clinical trials. Testosterone therapy remains an attractive option to many men even as speculation abounds regarding its potential.

Product Details

ISBN-13:
9780309090636
Publisher:
National Academies Press
Publication date:
02/12/2004
Pages:
240
Product dimensions:
6.00(w) x 9.00(h) x (d)

Table of Contents

Executive Summary1
1Introduction11
Scope of this Report11
Aging and Hormonal Changes12
Testosterone, Human Development, and Health14
Measuring Testosterone Levels18
Testosterone Therapy18
Growing Use of Testosterone Therapy24
Clinical Trials27
Organization of the Report28
References28
2Testosterone and Health Outcomes32
Changes in Endogenous Testosterone Levels with Aging33
Literature Review39
Bone41
Body Composition and Strength47
Physical Function54
Cognitive Function58
Mood and Depression61
Sexual Function66
Health-Related Quality of Life72
Cardiovascular and Hematologic Outcomes73
Prostate Outcomes81
Other Health Outcomes93
Multiple Outcomes93
Summary99
References100
3Future Research Directions112
Strategy for Future Clinical Trials in Older Men113
Recommendations117
Initial Efficacy Trials in Older Men119
Protection of Research Participants137
Additional Areas of Research152
Recommendations152
References152
4Concluding Remarks159
Need for Efficacy Studies in Older Men159
Clinical Studies in Middle-Aged Men161
Summary163
References163
Appendixes
AData Sources and Methods165
BRandomized Placebo-Controlled Trials of Testosterone Therapy in Older Men173
CAdditional Studies of Testosterone Therapy182
DTestosterone Levels in Clinical Studies198
EAcronyms202
FBiographical Sketches of Committee Members and Staff205
Index211

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