Textbook of Biochemistry: With Clinical Correlations / Edition 4

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Entirely revised and updated, this edition provides comprehensive, in-depth coverage of the subject. Each chapter includes an overview, a thorough treatment of the topic, followed by a bibliography and questions and answers. Unique to this book is the inclusion of clinical correlations which describe clinical examples of the consequences of malfunctioning biochemical pathways. The book introduces the chemistry and structure of cells and proceeds with discussion on proteins, enzymes, membrane structure and function, bioenergetics, metabolism of carbohydrates, lipids, amino acids and nucleic acids. It also covers all aspects of molecular biology.

The book contains both black-and-white and color illustrations.

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Editorial Reviews

Anatoly Bezkorovainy
This massive volume is a multiauthored textbook of biochemistry for medical students and other healthcare professionals. It is intended to be a teaching tool, rather than a reference book. It includes ""clinical correlations,"" which are not case reports. They, for the most part, are presented in general terms as opposed to situations observed in individual patients with specific blood analyte levels, clinical symptoms, and signs and prognosis/outcomes. It is my opinion that the latter approaches are more valuable (e.g., as done by the Montgomery text). Nevertheless, this volume is a significant contribution to the field and joins a number of similar, well-illustrated, massive texts on the market. The primary audience is medical students. One wonders, however, if the typical medical student would be capable of assimilating even a fraction of the material presented. On the other hand, there is not enough depth to be of much use for the graduate student. For example, the topic of enzymology, especially enzyme kinetics, although sufficient for the medical student, is inadequate for the graduate student. Each contributor has impeccable credentials. In this fourth edition, the authors have the opportunity to work out the ""bugs"" and optimize their chapters. The book is superbly illustrated, almost excessively so, with multiple colors serving useful pedagogic purposes. The bibliography is extensive, and for medical students, unnecessarily so. Tables of contents and indexes are excellent and useful. There are multiple-choice questions at the end of each chapter, with answers and explanations provided. There is an organic chemistry review section in the appendix. I was impressedwith the extensive sections on human nutrition, which are so useful for medical students. I do not agree with the relegation of carbohydrate, lipid, amino acid, and purine/pyrimidine chemistries to the organic chemistry appendix. The typical organic chemistry course in college is hardly sufficient to understand these most important biochemical topics. The book creates a good impression, even though it might be overwhelming for the typical medical student. It should be on every library shelf.
From The Critics
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This is a comprehensive biochemistry book aimed at first year medical students. The chapters are written by authorities in each of the respective areas. As with prior editions, there are numerous clinical vignettes that emphasize each of the topics. The book was originally published in 1982.
Purpose: This book is one of several targeted at the medical school market. The goal is to provide comprehensive coverage of biochemistry with sufficient clinical material to address the oft-raised issue of relevance. In general, this is a worthy enterprise since much of modern medical science has a biochemical base and the physicians of tomorrow should be conversant with the technology. As with other books with the same goals, the book is large, detailed, and likely difficult to use as a primary study vehicle.
Audience: The intended audience is first year medical students and possibly, graduate students in a biomedical sciences curriculum. The multiple authors are generally authorities in their respective areas.
Features: As with most books covering this area, this book starts with a discussion of macromolecular structure and uses this to proceed with coverage of information transfer (nuclei acid biochemistry). Aspects of protein structure as related to function are then discussed, including material on enzyme kinetics and membranes. Metabolism occupies the remainder and is divided into the common pathways of energy production and utilization, and biosynthesis followed by integration, control and specialized tissues. Each chapter is accompanied by a short bibliography and sample questions for review; illustrations are of good quality. A feature introduced in the initial edition is a set of accompanying clinical scenarios to highlight key points in the chapters. The index is reasonably comprehensive. A useful appendix provides a short review of organic chemistry, valuable for those students somewhat removed from that course. A common problem encountered in multiauthor books is also seen here. The flow of content is occasionally uneven and there is a lack of uniformity in approach or style. Conversely, the overall field is sufficiently broad that single author efforts usually suffer from serious knowledge gaps, not seen here. Technical errors are few; noticeable was the use of an improper structure for the saccharide unit covalently attached to collagen. A lack in the current environment is the failure to provide an accompanying electronic image or study guide. Students wishing a comprehensive text in biochemistry will find this book satisfactory.
Assessment: As a fifth edition, this book follows along well traveled territory. New material in key areas justifies the new edition. There are several competitive texts (Berg et al.'s Biochemistry, fifth edition (W.H. Freeman, 2002) and Voet's Biochemistry, second edition (John Wiley & Sons, 1995)), each of which has advantages and disadvantages for the target audience.
Covers the essential areas of general biochemistry and physiological chemistry--with an overriding emphasis on the biochemistry of mammalian cells--for upper-level undergraduate and graduate courses, especially courses presented in medical schools. The second editoin (1986) has been totally reevaluated, thoroughly revised and updated, and substantially rewritten to reflect advances in knowledge in the last five years, particularly due to the techniques of molecular biology. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780471170532
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 12/22/1997
  • Edition number: 4
  • Pages: 4
  • Product dimensions: 5.51 (w) x 4.92 (h) x 5.59 (d)

Table of Contents

1 Eukaryotic Cell Structure 1
2 Proteins I: Composition and Structure 23
3 Proteins II: Structure-Function Relationships in Protein Families 87
4 Enzymes: Classification, Kinetics, and Control 127
5 Biological Membranes: Structure and Membrane Transport 179
6 Bioenergetics and Oxidative Metabolism 217
7 Carbohydrate Metabolism I: Major Metabolic Pathways and their Control 267
8 Carbohydrate Metabolism II: Special Pathways 335
9 Lipid Metabolism I: Utilization and Storage of Energy in Lipid Form 361
10 Lipid Metabolism II: Pathways of Metabolism of Special Lipids 395
11 Amino Acid Metabolism 445
12 Purine and Pyrimidine Nucleotide Metabolism 489
13 Metabolic Interrelationships 525
14 DNA I: Structure and Conformation 563
15 DNA II: Repair, Synthesis, and Recombination 621
16 RNA: Structure, Transcription, and Processing 677
17 Protein Synthesis: Translation and Posttranslational Modifications 713
18 Recombinant DNA and Biotechnology 757
19 Regulation of Gene Expression 799
20 Biochemistry of Hormones I: Polypeptide Hormones 839
21 Biochemistry of Hormones II: Steroid Hormones 893
22 Molecular Cell Biology 919
23 Biotransformations: The Cytochromes P450 981
24 Iron and Heme Metabolism 1001
25 Gas Transport and pH Regulation 1025
26 Digestion and Absorption of Basic Nutritional Constituents 1055
27 Principles of Nutrition I: Macronutrients 1087
28 Principles of Nutrition II: Micronutrients 1107
App Review of Organic Chemistry 1137
Index 1149
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