Textbook of Biochemistry with Clinical Correlations / Edition 6

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Overview

"This book presents a clear and precise discussion of the biochemistry of eukaryotic cells, particularly those of mammalian tissues, relates biochemical events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of abnormal biochemical processes in human disease. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to human diseases"--Provided by publisher.

The book contains both black-and-white and color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This is the sixth edition of a well regarded general medical biochemistry textbook (first edition in 1982 with updates about every five years). The editor has assembled a strong group of contributing authors. Useful features include a short review of basic organic chemistry and a glossary.
Purpose: The goal is to offer a comprehensive biochemistry text to advanced students with a particular focus on medical students. As a basic science, this is an important goal. There is mixed success in meeting the objectives.
Audience: First year medical students are the target audience. Secondary users may include graduate students in the life sciences wishing a general text of biochemistry. The editor and authors are well qualified.
Features: The emphasis is on applications to medicine and hence the anticipated audience of first year medical students. The book's 28 chapters are grouped into five major sections. Each chapter has a set of study questions crafted in the format used for the step 1 examinations required for physician licensing; in addition, a short bibliography accompanies each section. Appendixes include a short review of organic chemistry (for those students who have taken this hurdle and now would like to forget it) and a useful glossary of common terms. As indicated in the title, clinical correlations are provided in offset text boxes to reinforce the relevance of the material to medical practice. As with most mega-texts, topical coverage begins with purely structural considerations; subsequent sections include detailed discussion of the central dogma (DNA - RNA - protein), protein function (including signal transduction), core metabolism, and a concluding section on hormones, cell cycle and nutrition. The coverage of all topics is reasonably thorough although there are some errors (dTDP-rhmnose is not a precursor of UDP-N-acetylgalactosamine). From a faculty perspective, little of consequence is missing and thus one might recommend this text. However, from a student perspective, the amount of material is overwhelming, there is no guidance as to relative importance (what do I really need to know?), and the clinical correlations sometimes appear to be dragged in. As both medical practice and its scientific underpinning become more integrated, our approach to teaching these materials should reflect this change. In a general sense, perhaps the time of the 1,000+ page textbook has passed.
Assessment: This is a large, comprehensive book with the flaws and virtues of all multiauthor efforts. Although complete, I would not recommend this book to students because they will not know how to read for essential content. This is a moving field and new editions are appropriate if that is the mechanism to keep book up-to-date. Whether such mega-volumes still have utility is debatable.
Anatoly Bezkorovainy
This massive volume is a multiauthored textbook of biochemistry for medical students and other healthcare professionals. It is intended to be a teaching tool, rather than a reference book. It includes ""clinical correlations,"" which are not case reports. They, for the most part, are presented in general terms as opposed to situations observed in individual patients with specific blood analyte levels, clinical symptoms, and signs and prognosis/outcomes. It is my opinion that the latter approaches are more valuable (e.g., as done by the Montgomery text). Nevertheless, this volume is a significant contribution to the field and joins a number of similar, well-illustrated, massive texts on the market. The primary audience is medical students. One wonders, however, if the typical medical student would be capable of assimilating even a fraction of the material presented. On the other hand, there is not enough depth to be of much use for the graduate student. For example, the topic of enzymology, especially enzyme kinetics, although sufficient for the medical student, is inadequate for the graduate student. Each contributor has impeccable credentials. In this fourth edition, the authors have the opportunity to work out the ""bugs"" and optimize their chapters. The book is superbly illustrated, almost excessively so, with multiple colors serving useful pedagogic purposes. The bibliography is extensive, and for medical students, unnecessarily so. Tables of contents and indexes are excellent and useful. There are multiple-choice questions at the end of each chapter, with answers and explanations provided. There is an organic chemistry review section in the appendix. I was impressedwith the extensive sections on human nutrition, which are so useful for medical students. I do not agree with the relegation of carbohydrate, lipid, amino acid, and purine/pyrimidine chemistries to the organic chemistry appendix. The typical organic chemistry course in college is hardly sufficient to understand these most important biochemical topics. The book creates a good impression, even though it might be overwhelming for the typical medical student. It should be on every library shelf.
Booknews
A text covering basic biochemistry, molecular biology, and normal and abnormal aspects of physiological chemistry, for students of medical and health sciences. Features color illustrations, detailed chapter contents showing page numbers of specific concepts, multiple choice quizes and explained answers, boxes on biochemistry in the human context, and an appendix reviewing organic chemistry. This fourth edition incorporates new findings in the field. Includes a CD-ROM containing all images from the book. Annotation c. by Book News, Inc., Portland, Or.
Booknews
Covers the essential areas of general biochemistry and physiological chemistry--with an overriding emphasis on the biochemistry of mammalian cells--for upper-level undergraduate and graduate courses, especially courses presented in medical schools. The second editoin (1986) has been totally reevaluated, thoroughly revised and updated, and substantially rewritten to reflect advances in knowledge in the last five years, particularly due to the techniques of molecular biology. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780471678083
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 12/16/2005
  • Edition description: Revised Edition
  • Edition number: 6
  • Pages: 1240
  • Product dimensions: 8.84 (w) x 11.16 (h) x 1.84 (d)

Meet the Author

Thomas M. Devlin, Ph.D. - Professor Emeritus, Drexel University School of Medicine.
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Table of Contents

Pt. I Structure of Macromolecules

1 Eukaryotic Cell Structure 1

2 DNA and RNA: Composition and Structure 25

3 Proteins I: Composition and Structure 75

Pt. II Transmission of Information

4 DNA Replication, Recombination, and Repair 139

5 RNA: Transcription and RNA Processing 181

6 Protein Synthesis: Translation and Posttranslational Modifications 209

7 Recombinant DNA and Biotechnology 255

8 Regulation of Gene Expression 303

Pt. III Functions of Proteins

9 Proteins II: Structure-Function Relationships in Protein Families 333

10 Enzymes: Classification, Kinetics, and Control 377

11 The Cytochromes P450 and Nitric Oxide Synthases 425

12 Biological Membranes: Structure, Receptors, and Solute Transport 457

13 Fundamentals of Signal Transduction 503

Pt. IV Metabolic Pathways and Their Control

14 Bioenergetics, Mitochondria, and Oxidative Metabolism 541

15 Carbohydrate Metabolism I: Major Metabolic Pathways and Their Control 591

16 Carbohydrate Metabolism II: Special Pathways and Glycoconjugates 647

17 Lipid Metabolism I: Synthesis, Storage, and Utilization of Fatty Acids and Triacylglycerols 673

18 Lipid Metabolism II: Pathways of Metabolism of Special Lipids 707

19 Amino Acid and Heme Metabolism 751

20 Purine and Pyrimidine Nucleotide Metabolism 807

21 Metabolic Interrelationships 839

22 Biochemistry of Hormones 883

Pt. V Physiological Processes

23 Molecular Cell Biology 939

24 Cell Cycle, Programmed Cell Death, and Cancer 1003

25 Digestion and Absorption of Basic Nutritional Constituents 1029

26 Vitamins and Minerals: Requirements and Function 1063

27 Macronutrients:Metabolic Effects and Health Implications 1101

Appendix Review of Organic Chemistry 1123

Glossary 1135

Index 1159

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