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Textbook of Biochemistry with Clinical Correlations / Edition 4

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Overview

Thomas M. Devlin's Textbook of Biochemistry with Clinical Correlations presents the biochemistry of mammalian cells, relates events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of human diseases derived from aberrant biochemical processes. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to humans. Loaded with new material and chapters and brimming with detailed, full-color illustrations that clearly explain associated concepts, this sixth edition is an indispensable tool for students and professionals in the medical or health sciences.

Key Features of the Sixth Edition:

  • Over 250 Clinical Correlations highlighting the significance of the biochemistry to clinical conditions and diseases
  • MCAT-Style Questions with annontated answers in every chapter - in a format similar to that used by the National Board of Medical Examiners
  • More than 1,200 high-quality, full-color illustrations
  • A concise appendix reviewing important Organic Chemistry Concepts

New to the Sixth Edition:

  • Fully Updated with a significant revision of all chapters and major topics
  • Two new chapters: Fundamentals of Signal Transduction and Cell Cycle, Programmed Cell Death, and Cancer
  • A Glossary that explains important biochemical terms New sections on the Basal Lamina Protein Complex and Molecular Motors

The book contains both black-and-white and color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Anatoly Bezkorovainy, JD, PhD (Rush Medical College of Rush University)
Description: This massive volume is a multiauthored textbook of biochemistry for medical students and other healthcare professionals.
Purpose: It is intended to be a teaching tool, rather than a reference book. It includes "clinical correlations," which are not case reports. They, for the most part, are presented in general terms as opposed to situations observed in individual patients with specific blood analyte levels, clinical symptoms, and signs and prognosis/outcomes. It is my opinion that the latter approaches are more valuable (e.g., as done by the Montgomery text). Nevertheless, this volume is a significant contribution to the field and joins a number of similar, well-illustrated, massive texts on the market.
Audience: The primary audience is medical students. One wonders, however, if the typical medical student would be capable of assimilating even a fraction of the material presented. On the other hand, there is not enough depth to be of much use for the graduate student. For example, the topic of enzymology, especially enzyme kinetics, although sufficient for the medical student, is inadequate for the graduate student. Each contributor has impeccable credentials. In this fourth edition, the authors have the opportunity to work out the "bugs" and optimize their chapters.
Features: The book is superbly illustrated, almost excessively so, with multiple colors serving useful pedagogic purposes. The bibliography is extensive, and for medical students, unnecessarily so. Tables of contents and indexes are excellent and useful. There are multiple-choice questions at the end of each chapter, with answers and explanations provided. There is an organic chemistry review section in the appendix. I was impressed with the extensive sections on human nutrition, which are so useful for medical students. I do not agree with the relegation of carbohydrate, lipid, amino acid, and purine/pyrimidine chemistries to the organic chemistry appendix. The typical organic chemistry course in college is hardly sufficient to understand these most important biochemical topics.
Assessment: The book creates a good impression, even though it might be overwhelming for the typical medical student. It should be on every library shelf.
Anatoly Bezkorovainy
This massive volume is a multiauthored textbook of biochemistry for medical students and other healthcare professionals. It is intended to be a teaching tool, rather than a reference book. It includes ""clinical correlations,"" which are not case reports. They, for the most part, are presented in general terms as opposed to situations observed in individual patients with specific blood analyte levels, clinical symptoms, and signs and prognosis/outcomes. It is my opinion that the latter approaches are more valuable (e.g., as done by the Montgomery text). Nevertheless, this volume is a significant contribution to the field and joins a number of similar, well-illustrated, massive texts on the market. The primary audience is medical students. One wonders, however, if the typical medical student would be capable of assimilating even a fraction of the material presented. On the other hand, there is not enough depth to be of much use for the graduate student. For example, the topic of enzymology, especially enzyme kinetics, although sufficient for the medical student, is inadequate for the graduate student. Each contributor has impeccable credentials. In this fourth edition, the authors have the opportunity to work out the ""bugs"" and optimize their chapters. The book is superbly illustrated, almost excessively so, with multiple colors serving useful pedagogic purposes. The bibliography is extensive, and for medical students, unnecessarily so. Tables of contents and indexes are excellent and useful. There are multiple-choice questions at the end of each chapter, with answers and explanations provided. There is an organic chemistry review section in the appendix. I was impressedwith the extensive sections on human nutrition, which are so useful for medical students. I do not agree with the relegation of carbohydrate, lipid, amino acid, and purine/pyrimidine chemistries to the organic chemistry appendix. The typical organic chemistry course in college is hardly sufficient to understand these most important biochemical topics. The book creates a good impression, even though it might be overwhelming for the typical medical student. It should be on every library shelf.
Booknews
A text covering basic biochemistry, molecular biology, and normal and abnormal aspects of physiological chemistry, for students of medical and health sciences. Features color illustrations, detailed chapter contents showing page numbers of specific concepts, multiple choice quizes and explained answers, boxes on biochemistry in the human context, and an appendix reviewing organic chemistry. This fourth edition incorporates new findings in the field. Includes a CD-ROM containing all images from the book. Annotation c. by Book News, Inc., Portland, Or.
Booknews
Covers the essential areas of general biochemistry and physiological chemistry--with an overriding emphasis on the biochemistry of mammalian cells--for upper-level undergraduate and graduate courses, especially courses presented in medical schools. The second editoin (1986) has been totally reevaluated, thoroughly revised and updated, and substantially rewritten to reflect advances in knowledge in the last five years, particularly due to the techniques of molecular biology. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780471154518
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 4/28/1997
  • Edition description: Older Edition
  • Edition number: 4
  • Pages: 1216
  • Product dimensions: 8.95 (w) x 11.36 (h) x 1.81 (d)

Meet the Author

Thomas M. Devlin, Ph.D. - Professor Emeritus, Drexel University School of Medicine.
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Table of Contents

1 Eukaryotic Cell Structure 1
2 Proteins I: Composition and Structure 23
3 Proteins II: Structure-Function Relationships in Protein Families 87
4 Enzymes: Classification, Kinetics, and Control 127
5 Biological Membranes: Structure and Membrane Transport 179
6 Bioenergetics and Oxidative Metabolism 217
7 Carbohydrate Metabolism I: Major Metabolic Pathways and their Control 267
8 Carbohydrate Metabolism II: Special Pathways 335
9 Lipid Metabolism I: Utilization and Storage of Energy in Lipid Form 361
10 Lipid Metabolism II: Pathways of Metabolism of Special Lipids 395
11 Amino Acid Metabolism 445
12 Purine and Pyrimidine Nucleotide Metabolism 489
13 Metabolic Interrelationships 525
14 DNA I: Structure and Conformation 563
15 DNA II: Repair, Synthesis, and Recombination 621
16 RNA: Structure, Transcription, and Processing 677
17 Protein Synthesis: Translation and Posttranslational Modifications 713
18 Recombinant DNA and Biotechnology 757
19 Regulation of Gene Expression 799
20 Biochemistry of Hormones I: Polypeptide Hormones 839
21 Biochemistry of Hormones II: Steroid Hormones 893
22 Molecular Cell Biology 919
23 Biotransformations: The Cytochromes P450 981
24 Iron and Heme Metabolism 1001
25 Gas Transport and pH Regulation 1025
26 Digestion and Absorption of Basic Nutritional Constituents 1055
27 Principles of Nutrition I: Macronutrients 1087
28 Principles of Nutrition II: Micronutrients 1107
App Review of Organic Chemistry 1137
Index 1149
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