A Textbook of Modern Toxicology / Edition 4

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Overview

A Textbook of Modern Toxicology is a unique resource that provides both students and practitioners with a wide-ranging, accessible overview of the discipline. Suitable for courses in environmental, pharmacological, medical, and veterinary toxicology, this essential text features chapters written by experts who address a range of key topics. The Fourth Edition includes additional chapters on new approaches to toxicology - molecular methods (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and systems biology - and continues the legacy of its predecessors to provide up-to-date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity testing, ecological risk assessment, and many other areas of toxicology that help foster a solid comprehension of the field. Also featured in the Fourth Edition are end-of-chapter questions and a Solutions Manual available separately for academic adopters.

The book contains black-and-white illustrations.

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Editorial Reviews

From the Publisher
"The book assumes a good knowledge of general toxicology and some knowledge of specialist areas, and would be a useful aid if studying for a higher degree where basic understanding has been." (British Toxicology Society, Winter 2010)
Booknews
This introductory toxicology textbook, updating the 1987 edition, contains 18 chapters addressing the following topics: absorption, distribution, metabolism, and elimination of toxicants; acute, chronic, and target organ toxicity; classes of toxic chemicals; measurement, testing, risk assessment, diagnosis, treatment, and prevention of toxicity; toxicants in the environment; ecological risk assessment; and environmental and human health. Annotation c. by Book News, Inc., Portland, Or.
From Barnes & Noble
Includes an overview of the science of toxicology and chapters on the human body's absorption and reaction to various toxicants, from pesticides & food additives to drugs; toxicity diagnosis, treatment, & prevention; more.
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Product Details

  • ISBN-13: 9780470462065
  • Publisher: Wiley
  • Publication date: 6/21/2010
  • Edition description: New Edition
  • Edition number: 4
  • Pages: 672
  • Sales rank: 625,680
  • Product dimensions: 7.20 (w) x 10.00 (h) x 1.40 (d)

Meet the Author

ERNEST HODGSON, PhD, is Distinguished Professor Emeritus of Toxicology at North Carolina State University. In addition to the previous editions of A Textbook of Modern Toxicology, he coedited Molecular and Biochemical Toxicology, Fourth Edition (Wiley) and its prior editions. Dr. Hodgson is the Editor of the Journal of Biochemical and Molecular Toxicology.

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Table of Contents

Preface to the Fourth Edition.

Contributors.

PART I Introduction.

1 Introduction to Toxicology (Ernest Hodgson).

1.1 Definition and Scope.

1.2 Relationship to Other Sciences.

1.3 A Brief History of Toxicology.

1.4 Dose-Response Relationships.

1.5 Sources of Toxic Compounds.

1.6 Movement of Toxicants in the Environment.

2 Introduction to Biochemical and Molecular Methods inToxicology (Ernest Hodgson, Gerald A. LeBlanc, Sharon A.Meyer and Robert C. Smart).

2.1 Introduction.

2.2 Cell Culture Techniques.

2.3 Molecular Techniques.

2.4 Immunochemical Techniques.

2.5 Proteomics.

2.6 Metabolomics.

2.7 Bioinformatics.

2.8 Summary and Conclusions.

PART II Classes of Toxicants.

3 Exposure Classes, Toxicants in Air, Water, Soil, Domesticand Occupational Settings (W. Gregory Cope).

3.1 Air Pollutants.

3.2 Water and Soil Pollutants.

3.3 Occupational Toxicants.

4 Classes of Toxicants: Use Classes (W. Gregory Copeand Ernest Hodgson).

4.1 Introduction.

4.2 Metals.

4.3 Agricultural Chemicals (Pesticides).

4.4 Food Additives and Contaminants.

4.5 Toxins.

4.6 Solvents.

4.7 Therapeutic Drugs.

4.8 Drugs of Abuse.

4.9 Combustion Products.

4.10 Cosmetics.

PART III Toxicant Processing In Vivo.

5 Absorption and Distribution of Toxicants (Ronald E.Baynes and Ernest Hodgson).

5.1 Introduction.

5.2 Cell Membranes.

5.3 Mechanisms of Transport.

5.4 Physicochemical Properties Relevant to Diffusion.

5.5 Routes of Absorption.

5.6 Toxicant Distribution.

5.7 Toxicokinetics.

6 Metabolism of Toxicants (Ernest Hodgson and Randy L.Rose).

6.1 Introduction.

6.2 Phase I Reactions.

6.3 Phase II Reactions.

7 Reactive Metabolites (Ernest Hodgson and Randy L.Rose).

7.1 Introduction.

7.2 Activation Enzymes.

7.3 Nature and Stability of Reactive Metabolites.

7.4 Fate of Reactive Metabolites.

7.5 Factors Affecting Toxicity of Reactive Metabolites.

7.6 Reactive Oxygen Species.

7.7 Examples of Activating Reactions.

7.8 Summary and Conclusions.

8 Chemical and Physiological Influences on XenobioticMetabolism (Andrew D. Wallace and Ernest Hodgson).

8.1 Introduction.

8.2 Nutritional Effects.

8.3 Physiological Effects.

8.4 Comparative and Genetic Effects.

8.5 Chemical Effects.

8.6 Environmental Effects.

8.7 Summary and Conclusions.

9 Elimination of Toxicants (Gerald A.LeBlanc).

9.1 Introduction.

9.2 Transport.

9.3 Renal Elimination.

9.4 Hepatic Elimination.

9.5 Respiratory Elimination.

9.6 Conclusion.

PART IV Toxic Action.

10 Acute Toxicity (Gerald A. LeBlanc).

10.1 Introduction.

10.2 Acute Exposure and Effect.

10.3 Dose-Response Relationships.

10.4 Non-Conventional Dose–Response Relationships.

10.5 Alternative Methods.

10.6 Mechanisms of Acute Toxicity.

11 Chemical Carcinogenesis (Robert C. Smart).

11.1 DNA Damage and Mutagenesis.

11.2 General Aspects of Cancer.

11.3 Human Cancer.

11.4 Classes of Agents That Are Associated withCarcinogenesis.

11.5 General Aspects of Chemical Carcinogenesis.

11.6 Oncogenes.

11.7 Tumor Suppressor Genes.

12 Teratogenesis (Jill A. Barnes and Ida M.Washington).

12.1 Introduction.

12.2 Overview of Embryonic Development.

12.3 Principles of Teratogenesis.

12.4 Mechanisms of Teratogenesis.

12.5 Future Considerations.

PART V Organ Toxicity.

13 Hepatotoxicity (Andrew D. Wallace and Sharon A.Meyer).

13.1 Introduction.

13.2 Susceptibility of the Liver.

13.3 Types of Liver Injury.

13.4 Mechanisms of Hepatotoxicity.

13.5 Examples of Hepatotoxicants.

13.6 Metabolic Activation of Hepatotoxicants.

14 Nephrotoxicity (Joan B. Tarloff and Andrew D.Wallace).

14.1 Introduction.

14.2 Factors Contributing to Nephrotoxicity.

14.3 Examples of Nephrotoxicants.

14.4 Summary.

15 Toxicology of the Nervous System (Bonita L.Blake).

15.1 Introduction.

15.2 The Nervous System.

15.3 Toxicant Effects on the Nervous System.

15.4 Neurotoxicity Testing.

15.5 Summary.

16 Reproductive System (Heather Patisaul).

16.1 Introduction.

16.2 The-Hypothalamic-Pituitary-Gonadal Axis.

16.3 Male Reproductive Physiology.

16.4 Disruption of Male Reproduction by Toxicants.

16.5 Female Reproductive Physiology.

16.6 Disruption of Female Reproduction by Toxicants.

16.7 Summary.

17 Endocrine Toxicology (Gerald A. LeBlanc).

17.1 Introduction.

17.2 Endocrine System.

17.3 Endocrine Disruption.

17.4 Incidents of Endocrine Toxicity.

17.5 Conclusion.

18 Respiratory Toxicity (James C. Bonner).

18.1 Introduction.

18.2 Anatomy and Function of the Respiratory Tract.

18.3 Toxicant-Induced Lung Injury, Remodeling and Repair.

18.4 Occupational and Environmental Lung Diseases.

19 Immune System (MaryJane K. Selgrade).

19.1 Introduction.

19.2 The Immune System.

19.3 Immune Suppression.

19.4 Classification of Immune-Mediated Injury(Hypersensitivity).

19.5 Effects of Chemicals on Allergic Disease.

19.6 Other Issues: Autoimmunity, and the Developing ImmuneSystem.

PART VI Applied Toxicology.

20 Toxicity Testing (Ernest Hodgson and HelenCunny).

20.1 Introduction.

20.2 Experimental Administration of Toxicants.

20.3 Chemical and Physical Properties.

20.4 Exposure and Environmental Fate.

20.5 In Vivo Tests.

20.6 In Vitro and Other Short-Term Tests.

20.7 Ecological Effects.

20.8 Risk Analysis.

20.9 The Future of Toxicity Testing.

21 Forensic and Clinical Toxicology (Sharon A. Meyerand Bonita L. Blake).

21.1 Introduction.

21.2 Forensic Toxicology.

21.3 Clinical Toxicology.

21.4 Analytical Methods in Forensic and Clinical Toxicology.

22 Prevention of Toxicity (Ernest Hodgson).

22.1 Introduction.

22.2 Legislation and Regulation.

22.3 Prevention in Different Environments.

22.4 Education.

23 Human Health Risk Assessment (Ronald E.Baynes).

23.1 Introduction.

23.2 Risk Assessment Methods.

23.3 Noncancer Risk Assessment.

23.4 Cancer Risk Assessment.

23.5 PBPK Modeling.

Part VII Environmental Toxicology.

24 Toxicant Analysis (Chris Hofelt).

24.1 Introduction.

24.2 Environmental Sample Collection Methods.

24.3 Analytical Techniques.

24.4 Quantification, QA and QC.

24.5 Summary.

25 Basics of Environmental Toxicology (Gerald A.LeBlanc and David B. Buchwalter).

25.1 Introduction.

25.2 Environmental Persistence.

25.3 Bioaccumulation.

25.4 Toxicity.

25.5 Conclusion.

26 Transport and Fate of Toxicants in the Environment(Damian Shea).

26.1 Introduction.

26.2 Sources of Toxicants to the Environment.

26.3 Transport Processes.

26.4 Equilibrium Partitioning.

26.5 Transformation Processes.

26.6 Environmental Fate Models.

27 Environmental Risk Assessment (DamianShea).

27.1 Introduction.

27.2 Formulating the Problem.

27.3 Analyzing Exposure and Effects Information.

27.4 Characterizing Risk.

27.5 Managing Risk.

Part VIII New Approaches in Toxicology.

28 Perspectives on Informatics in Toxicology (Seth W.Kullman, Carolyn J. Mattingly, Joel N. Meyer and AndrewWhitehead).

28.1 Introduction.

28.2 Transcriptomics.

28.3 Annotation Resources.

28.4 Genome Sequencing, Resequencing and Genotyping.

28.5 Epigenomic Profiling.

28.6 Computational Toxicology.

28.7 Informatics Tools in Toxicology.

29 Future Considerations (Ernest Hodgson).

29.1 Introduction.

29.2 Risk Assessment.

29.3 Risk Management.

29.4 Risk Communication.

29.5 In Vivo Toxicity.

29.6 In Vitro Toxicity.

29.7 Molecular and Biochemical Toxicology.

29.8 Development of Selective Toxicants.

29.9 Summary and Conclusions.

Glossary.

Index.

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