Textbook of Nephro-Endocrinology

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Overview

"…Singh and Williams have clearly chosen their authors well. The experts responsible for each chapter are clearly very knowledgeable and did an outstanding job of sharing that knowledge with the reader. Very often in books of this kind the density of the detail makes the reading rather difficult. Not in the case of this monograph. The reading is easy."

—Norman K. Hollenberg, M.D., Ph.D., Department of Medicine, Brigham and Women's Hospital, Harvard, Boston, MA, USA

Key Features:

  • Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference
  • Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems
  • Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field

About the Editors:

Ajay K. Singh, MD is Associate Professor of Medicine at Harvard Medical School in Boston, Massachusetts. He is also Director of Post-Graduate Medical Education in the Department of Medicine and Director of Dialysis Services of Brigham and Women’s Hospital, Boston, Massachusetts. Dr. Singh received a bachelor of science degree in psychology from University College, University of London, London, United Kingdom. He received a doctor of medicine degree from University College Hospital. As part of his postdoctoral training, Dr. Singh performed his internship at Stafford General Infirmary and Stoke Mandeville Hospital and his residency at Southend Hospital in the United Kingdom. His renal fellowship was at the Tufts–New England Medical Center in Boston, Massachusetts. In addition to his degree in medicine, Dr. Singh holds a master’s degree in business administration from the Boston University School of Management.

Gordon H. Williams, M.D. received his BA summa cum laude from Harvard University and MD cum laude from Harvard Medical School (HMS). After serving an internship at the University of Chicago and medicine residency and fellowship in endocrinology at the Peter Bent Brigham Hospital, he joined the faculty at HMS where he has been a Professor of Medicine since 1981. He is the Director of the Clinical Research K-12 MeRIT program and a member of the Operations Committee of the Harvard Catalyst—Harvard Clinical and Translational Science Center. He is also Director of the following activities at the Brigham & Women’s Hospital: the Center for Clinical Investigation, the Hormonal Mechanisms of Cardiovascular Injury Laboratory, and Cardiovascular Endocrinology Section. His research activities have focused on the genetics of complex diseases involving hormonal mechanisms. In 2000 the American Heart Association honored Dr. Williams for his genetic studies as the Lewis A. Conner Lecturer. In 2008 the American Society of Hypertension bestowed its highest honor on him, the Robert Tigerstedt Award.

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Editorial Reviews

From the Publisher
"Singh and Williams have clearly chosen their authors well. The experts responsible for each chapter are clearly very knowledgeable and did an outstanding job of sharing that knowledge with the reader. Very often in books of this kind the density of the detail makes the reading rather difficult. Not in the case of this monograph. The reading is easy" —-Norman K. Hollenberg, M.D., Ph.D., Department of Medicine, Brigham and Women's Hospital, Harvard, Boston, MA, USA

"This well-written, relatively concise, and current book will find a home on the shelves of many nephrologists and endocrinologists. Because it is so readable, it should be useful for students, experts, and those in between. I know I will consult my copy on a frequent basis — an unusual event in this era of online material."

— As reviewed in N Engl J Med 2009; 361: 832

"All in all, this is a solid book that provides substantial up-todate information on endocrine aspects of the kidney. I will be glad to pull it down from my shelf rather than one of the true heavyweights to which I would previously have gone for this kind of reading." — Kidney International (2009)

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Product Details

  • ISBN-13: 9780123738707
  • Publisher: Elsevier Science
  • Publication date: 1/2/2009
  • Pages: 522
  • Product dimensions: 8.70 (w) x 10.90 (h) x 1.40 (d)

Table of Contents

Part 1: The Kidney as an Endocrine Organ
Section 1: Erythropoietin
1.Erythropoientin: An Historical Overview of Physiology, Molecular Biology And Gene Regulation

2.Erythropoiesis: The Role of Erythropoietin and Iron

3.Extra-Hematopoietic Action of Erythropoietin

4.Development of Recombinant Erythropoietin and Erythropoietin Analogues

5.Erythropoietin Disease States & Resistance

Section 2: Vitamin D, PTH and Novel Regulators of Phosphate

6. Vitamin D and the Kidney: Introduction and Historical Perspective

7.Vitamin D: Molecular Biology and Gene Regulation

8.Molecular Biology of Parathyroid Hormone

9.Endocrine Regulation of Phosphate Homeostasis

Section 3: Renin-angiotensin
10.Introduction and Historical Overview

11.Molecular Biology of Renin and Regulation of Its Gene

12. Physiology and Regulation of the RAAS System

13. The Renin Angiotensin Aldosterone System and the Kidney

14. The Renin Angiotensin and the Heart
15. The Renin-Angrotensin blockade: Therapeutic Agents

Part 2: The Kidney as a Hormonal target
Section 4: Anti-diuretic Hormone
16. Vasopressin in the Kidney: Historical Aspects

17. Molecular Biology and Gene Regulation

18. Vasopressin Antagonists in Physiology and Disease

19. Diabetes Insipidus and SIADH

Section 5: The Atrial Natriuretic Peptides

20. ANP, BNP and CNP Physiology and Pharmacology of the Cardiorenal Axis

Section 6: Aldosterone
21.Introduction and Historical Overview

22.Aldosterone Receptors and Their Renal Effects: Molecular Biology
And Gene Regulation

23. Aldosterone and Its Cardiovascular Effects

24. Aldosterone Regulation

Section 7: Endocrine Disorders in Renal Failure

25. Insulin resistance
26. Growth hormone
27. Sexual Dysfunction in Men and Women with Chronic Kidney Disease

28. Thyroid Status in Chronic Renal Failure Patients

29.Metabolic Acidosis of Chronic Kidney Disease
30.Pregnancy and the Kidney

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Sort by: Showing all of 2 Customer Reviews
  • Posted July 20, 2009

    Expertly written

    This text handsomely bridges the overlapping territories of nephrologists, endocrinologists and cardiologists. The editors have collected a top-notch group of experts to provide in-depth lessons in physiology and therapeutics suitable for academics, clinicians and researchers. Topics include the kidney as an endocrine organ (erythropoietin, Vitamin D, PTH, and the renin-angiotensin-aldosterone system), as well as the kidney as hormonal target (ADH, ANP/BNP, aldosterone). A valuable detailed resource of highest quality.

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  • Anonymous

    Posted May 14, 2009

    Nephro-Endocrinology in one comprehensive text

    This excellent book is written to enlighten the novice and extend the knowledge base of the established investigator. The information will be of value to master's or PhD trainees, medical students, students in other biomedical professional disciplines, scientists in industry, practicing clinical investigators and administrators in the broad fields of nephrology and endocrinology.

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