Textbook of Neural Repair and Rehabilitation, Volume 1: Neural Repair and Plasticity

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Overview

In two freestanding volumes, Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. This volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal CNS, mechanisms of neuronal death, axonal regeneration, stem cell biology, and neuron replacement. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.

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Editorial Reviews

From the Publisher
'In two freestanding but linked volumes, Textbook of Natural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Edited and written by leading international authorities from the neurosciences and clinical neurorehabilitation, the two-volume set is an essential resource for rehabilitation professionals and a comprehensive reference for all scientists and clinicians in the field.' Advances in Clinical Neuroscience & Rehabilitation
Doody's Review Service
Reviewer: Richard L. Harvey, MD (Northwestern University Feinberg School of Medicine)
Description: The book is presented in two volumes: Neural Repair and Plasticity and Medical Neurorehabilitation. Although each of these volumes could stand alone, they are clearly linked and indeed are better together than they are separate. Volume one focuses on the basic science of neuroplasticity and neural repair. The first sections cover physiological neuroplasticity and plasticity in the context of neural injury. The later sections cover the topic of neural repair. Volume two covers many areas of rehabilitation, including motor recovery, but also other issues that are not well covered in many books, such as autonomic dysfunction, sensory rehabilitation, balance, and dysphagia.
Purpose: This book is the first major attempt to link neuroscience to clinical neurology and rehabilitation. Both the editors and the chapter authors are of varied scientific disciplines that include neurobiology, neuroanatomy, physiology, engineering, neurology, physical medicine and rehabilitation, physical therapy, psychology, and orthopedic surgery. These two volumes contain much of the valuable basic and clinical science gleaned over many decades of research and especially more recently, during the 1990s (the decade of the brain).
Audience: This is an advanced text for the postgraduate level and should be owned by anyone who is developing a career in neuroscience, neural repair, or neurorehabilitation. It is intended for neuroscientists, clinical researchers, and neurorehabilitation practitioners. The editors and authors are all credible authorities.
Features: The introductory chapter to this exciting new book is cowritten by the editors and sets the tone for the two volumes. Importantly, it defines terminology for the reader and reviews modern concepts of disablement. Much of this chapter focuses on the history of rehabilitation and it is a good review. It correctly notes that much of rehabilitation originates from practice and care of people with neurological disease, but only recently has gained a scientific basis through the efforts of neuroscience and neurology. However, it fails to credit the field of physical medicine and rehabilitation for its important contribution of interdisciplinary care, which is the foundation of neurorehabilitation. Indeed, no translational research could possibly have a meaningful impact on neural recovery and neurorehabilitation without an interdisciplinary team of professionals. The section organization works nicely, but the chapters within each section are not well linked to one another. However, each chapter stands well on its own. One may find that the organization of many of the sections is rather odd. For example the chapters in section B2 entitled "Vegetative and Autonomic Dysfunctions" include the rehabilitation of the comatose patient, swallowing, autonomic dysfunction, and sexuality. These are not topics one would naturally cast in the same group. However, they do cover important topics and are valuable to the reader. Volume two falls short in addressing the important area of outcome measures in rehabilitation. As neurorehabilitation has emerged as a clinical science, the problem of measuring clinical outcomes has become increasingly important. Unfortunately, this book does not adequately cover this topic area. A chapter on outcomes in stroke rehabilitation in the section entitled "Outcomes measurement and diagnostic technology" reviews primarily the methodology for developing an outcome measure. Other sections cover therapeutic technology and disease specific rehabilitation and each is a good, up-to-date review of these specific areas. Black-and-white figures are used throughout and enhance the material. A handful of color plates appear in the middle of volume one.
Assessment: This is a timely and important book with interest for a broad range of scientists and practitioners of neurorehabilitation. It is an excellent reference for the postgraduate. However, because this is a fast growing field, this book may be dated in three to five years. Hopefully, a second edition will be forthcoming by then.
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Product Details

  • ISBN-13: 9780521856416
  • Publisher: Cambridge University Press
  • Publication date: 1/31/2006
  • Edition description: Older Edition
  • Pages: 724
  • Product dimensions: 7.44 (w) x 9.69 (h) x 1.54 (d)

Meet the Author

Michael Selzer is Professor of Neurology at the University of Pennsylvania and Research Director in the Department of Physical Medicine Rehabilitation. He is editor-in-chief of Neurorehabilitation and Neural Repair, the official Journal of the American Society of Neurorehabilitation and the World Federation of Neurorehabilitation.

Stephanie Clarke is Professor and Head of Neuropsychology at the University Hospital, Lausanne and President of the Swiss Society of Neurorehabiltation.

Leonardo Cohen is Chief of the Human Cortical Physiology Section and Chief of the Stroke Rehabilitation Clinic at NINDS, Bethesda.

Pamela Duncan is Professor of Health Services Administration and Physical Therapy, and Director of the University of Florida Brooks Center for Rehabilitation Studies, University of Florida.

Fred Gage is Professor in the Laboratory of Genetics at the Salk Institute, and served as President of the Society for Neuroscience, 2001-2. He is a fellow of the American Association for the Advancement of Science and a member of the National Academy of Sciences and the Institute of Medicine

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Table of Contents

Preface; Neural repair and rehabilitation: an introduction; Part A. Neural plasticity: Part A1. Cellular and molecular mechanisms of neural plasticity: 1 Anatomical and biochemical plasticity of neurons: regenerative growth of axons, sprouting, pruning, and denervation; supersensitivity; 2 Learning and memory: basic principles and model systems; 3 Short-term plasticity: facilitation and post-tetanic potentiation; 4 Long-term potentiation and long-term depression; 5 Cellular and molecular mechanisms of associative and nonassociative learning; Part A2. Functional Plasticity in CNS System: 6 Plasticity of mature and developing somatosensory systems; 7 Activity-dependent plasticity in the intact spinal cord; 8 Plasticity of cerebral motor functions: implications for repair and rehabilitation; 9 Plasticity in visual connections: retinal ganglion cell axonal development and regeneration; 10 Plasticity in auditory functions; 11 Cross-modal plasticity in sensory systems; 12 Attentional modulation of cortical plasticity; Section A3. Plasticity after injury to the CNS; 13 Plasticity in the injured spinal cord; 14 Plasticity after brain lesions; 15 From bench to bedside: influence of theories of plasticity on human neurorehabilitation; Part B. Neural Repair: Part B1. Basic Cellular and Molecular Processes: 16 Neuronal death and rescue: neurotrophic factors and anti-apoptotic mechanisms; 17 Axon degeneration and rescue; 18 Adult neurogenesis and neural precursors, progenitors, and stem cells in the adult CNS; 19 Axon guidance during development and regeneration; 20 Synaptogenesis; Part B2. Determinants of Regeneration in the Injured Nervous System: 21 Inhibitors of axonal regeneration; 22 Effects of the glial scar and extracellular matrix molecules on axon regeneration; 23 Trophic factors and their influence on regeneration; 24 Intraneuronal determinants of regeneration; Part B3. Promotion of Regeneration in the Injured Nervous System: 25 Cell replacement in spinal cord injury; 26 Dysfunction and recovery in demyelinated and dysmyelinated axons; 27 Role of Schwann cells in peripheral nerve regeneration; 28 Transplantation of Schwann cells and olfactory ensheathing cells to promote regeneration in the CNS; 29 Trophic factor delivery by gene; 30 Assessment of sensorimotor function after spinal cord injury and repair; Part B4. Translational Research: Application to Human Neural Injury: 31 Alzheimer's disease, model systems and experimental therapeutics; 32 Biomimetic design of neural prostheses; 33 Brain-computer interfaces for communication and control; 34 Status of neural repair clinical trials in brain diseases; Index.

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