The Autoimmune Diseases

by M. Eric Gershwin (Editor), George C. Tsokos MD (Editor)

Overview

Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.

New to This Edition:* Tissue-specific interventions to arrest or "cure" autoimmune disease* Bone marrow eradication and replacement* Both basic science and clinical medicine is covered* Boxed points to emphasize key features of each chapter

Product Details

ISBN-13:	9780080454740
Publisher:	Elsevier Science & Technology Books
Publication date:	05/15/2006
Sold by:	Barnes & Noble
Format:	eBook
Pages:	1160
File size:	36 MB
Note:	This product may take a few minutes to download.

About the Author

Noel Rose was born in Stamford, Connecticut. He attended Yale University for his undergraduate education followed by the University of Pennsylvania for a Ph.D. and State University of New York at Buffalo for an MD. He was a member of the faculty of the State University of New York at Buffalo School of Medicine for a period of 20 years, rising through the ranks to become a professor of Microbiology and Medicine, Director of Clinical Laboratories and Director of the Center for Immunology. He then spent ten years at Wayne State University School of Medicine where he chaired the Department of Immunology and Microbiology. In 1981, he joined the faculty of Johns Hopkins University as chairman of the Department of Immunology and Infectious Diseases. He presently holds professorial appointments in the Departments of Pathology, Molecular Microbiology and Immunology, Medicine and Environmental Health Sciences at The Johns Hopkins University and directs the Center for Autoimmune Disease Research. Dr. Rose’s original investigations on the autoimmune basis of thyroid disease in 1956 opened the present era of research on autoimmunity. He has since investigated many areas of autoimmunity and related issues in clinical and basic immunology. Dr. Rose is the author or co-author of over 800 scientific papers and editor or co-editor of 24 books. He has received numerous honors, including two honorary doctoral degrees, election to fellowship in national or international societies, service in national and international organizations and editorial boards of leading journals.
In the 1950s and 1960s Professor Mackay led the field of research into autoimmune diseases, coining the term ‘autoimmunity’.
In 1963, he and Sir Macfarlane Burnet published a definitive monograph on the subject, firmly placing autoimmunity on the research map. Professor Mackay defined major autoimmune diseases of the liver and devised a life-saving protocol for autoimmune hepatitis that remains standard today. He also advanced knowledge on many other expressions of autoimmunity.

Table of Contents

GENERAL AND BASIC IMMUNOLOGY
SPECIFIC AUTOIMMUNE DISEASES
RHEUMATIC DISEASES
ENDOCRINE/EXOCRINE DISEASES
HEMATOLOGIC DISEASES
NERVOUS/MUSCULOSKELETAL/SKIN DISEASES
PRACTICE

What People are Saying About This

From the Publisher

Fully revised and updated to include the latest research in the field, The Autoimmune Diseases, 5^th Edition, remains an essential resource for basic and clinical scientists committed to the study, diagnosis, and treatment of autoimmune disorders.

Editorial Reviews

This third edition is edited by two distinguished experts in the field of autoimmune diseases. Even the cover of the book is pleasing, with the fluorescent glow of an anti-nuclear antibody stain. "The purpose is to provide a comprehensive resource for all facets of autoimmune disease. "It is intended for clinicians of many stripes as well as basic immunologists. "The organization of the book is excellent. The definition of autoimmunity is addressed with a focus on actual diseases, distinguishing between autoimmune epiphenomena and actual diseases. This distinction has been confronted by many clinicians; it has many pernicious influences on the care of patients, mostly in the area of unneeded corticosteroid therapy or false diagnosis labels that place stress on both insurance companies and physicians. The mysteries of self tolerance are also explored. The entire gamut of autoimmune disease is discussed in a format that begins with basic mechanisms, extends through diagnosis, and then on to therapy. There are several favorite chapters for me: a potpourri of cameos and curiosities that may be related to autoimmune phenomenon; and a well-balanced chapter on the hazards of diagnosis, including the misuse of the ANA diagnosis. The final chapter provides an historical perspective on the evolution of the understanding of autoimmunity; this is done without deconstruction. "This outstanding book is recommended for any and all physicians who care for patients with autoimmune diseases. It should serve as the primary source for fundamental and contemporary concepts of autoimmunity.

John A. Robinson

New edition of a text that addresses two related questions<-->what designates an autoimmune disease and what are the common threads uniting the autoimmune diseases. The scientific chapters include mechanisms of natural tolerance, the genetic basis of autoimmunity, the significance of apoptosis, the influence of cytokines, environmental influences, and experimental models. The clinical chapters cover autoimmune endocrine deficiencies, insulin-dependent diabetes, rheumatic disorders, neurological diseases, and diseases of the blood, skin, eye, kidney and liver. Annotation c. by Book News, Inc., Portland, Or.

Booknews

"...edited by Noel R. Rose and Ian R. Mackay, widely recognized experts in autoimmunity and its pathophysiological and clinical aspects...This thoughtfully updated new edition takes into consideration important developments in basic and clinical science...This book will be a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune diseases, to scientists who want to follow developments in the field, and to all those who enjoyed the previous edition." —Martha M. Eibl, M.D. for NEW ENGLAND JOURNAL OF MEDICINE (Jan 2006)

From the Publisher