The Behavioral Neurology of White Matter

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This unique book examines the role of the brain's white matter in the organization of human mental function. In contrast to standard textbooks of behavioral neurology and neuropsychiatry that emphasize the cortical and subcortical gray matter in brain-behavior relationships, this text specifically considers the white matter as a vital contributor to cognition and emotion. Written from a clinical perspective, this book is founded on the study of patients with neurobehavioral syndromes resulting from disorders primarily affecting the brain's white matter. These syndromes include white matter dementia, focal neurobehavioral syndromes, and a variety of neuropsychiatric syndromes. In the first part of the book, fundamental aspects of myelinated systems are covered to introduce white matter as an important structural and functional component of the brain. In Part II, a thorough review of white matter disorders at all ages is provided, particularly regarding their impact on normal mentation. Finally, Part III synthesizes the collected information into a coherent summary that presents a behavioral neurology of white matter. Throughout the book a major emphasis is placed on distributed neural networks, in which connecting white matter tracts complement the operations of gray matter structures in the production of the human behavioral repertoire.
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Editorial Reviews

Doody's Review Service
Reviewer: Ronald Sims, MD (Dubuque Internal Medicine)
Description: This brief work is concerned with the neurobehavioral aspects of white matter diseases.
Purpose: The author's objective is to describe the behavioral neurology of the white matter. This is a thought-provoking topic that is well addressed in this book.
Audience: The principal audience is neurologists, psychiatrists, and psychologists. The author, a behavioral neurologist, has published numerous papers in his field.
Features: The book includes sections on the structure, function, developmental aspects, and neuroradiology of white matter plus larger sections on a wide range of diseases that primarily involve white matter. Cognitive aspects of these diseases are addressed in a third section. The best feature of this book is that it explores the premise that it is reasonable to conceive of the white matter as interacting with the gray matter to produce human behavior.
Assessment: This book is fascinating and thought-provoking. It pulls together much information that would not usually be found in one place It places less emphasis on treatment, even in conditions where treatment is currently controversial, such as normal pressure hydrocephalus.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780195135619
  • Publisher: Oxford University Press, USA
  • Publication date: 9/13/2001
  • Edition description: New Edition
  • Pages: 304
  • Product dimensions: 8.90 (w) x 6.10 (h) x 1.10 (d)

Table of Contents

Pt. I The Brain, the Mind, and White Matter 1
1 The Neurologic Background 3
2 White Matter Structure and Function 19
3 Development and Aging 32
4 Neuroimaging 41
Pt. II Disorders of White Matter 57
5 Genetic Disorders 59
6 Demyelinative Diseases 81
7 Infectious Diseases 97
8 Inflammatory Diseases 109
9 Toxic Leukoencephalopathies 118
10 Metabolic Disorders 136
11 Vascular Diseases 146
12 Traumatic Disorders 165
13 Neoplasms 175
14 Hydrocephalus 187
Pt. III White Matter and Higher Function 199
15 Cognitive Dysfunction and Dementia 201
16 Focal Neurobehavioral Syndromes 219
17 Neuropsychiatric Syndromes 231
18 The Behavioral Neurology of White Matter 247
Index 269
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