The Carbonic Anhydrases: Cellular Physiology and Molecular Genetics

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Contributors discuss how carbonic anhydrases help the body combat some of the physical ills of industrialization stemming from the greenhouse effect, ozone depletion, acid rain, and the general increase of CO2 in the atmosphere. They show how these enzymes are responsible for converting CO2 into HCO3, which is the biggest intracellular buffer, with a concomitant decrease in a hydroxyl ion. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9781489907523
  • Publisher: Springer US
  • Publication date: 11/20/2013
  • Edition description: Softcover reprint of the original 1st ed. 1991
  • Pages: 380
  • Product dimensions: 6.10 (w) x 9.25 (h) x 0.82 (d)

Table of Contents

I. The Carbonic Anhydrase Isozymes.- 1. The Carbonic Anhydrases: Overview of Their Importance in Cellular Physiology and in Molecular Genetics.- 2. Structure and Evolutionary Origins of the Carbonic Anhydrase Multigene Family.- 3. X-Ray Crystallographic Studies of Carbonic Anhydrase Isozymes I, II, and III.- 4. Carbonic Anhydrase Kinetics and Molecular Function.- 5. Carbonic Anhydrases in Mammalian Cell Culture and Tumors.- 6. Methods for the Measurement of Carbonic Anhydrase Activity.- II. Carbonic Anhydrase Analysis.- 7. Purification of the Carbonic Anhydrases.- 8. Techniques for Measuring Carbonic Anhydrase Activity in Vitro: The Electrometric Delta pH and pH Stat Methods.- 9. Modified Micromethod for Assay of Carbonic Anhydrase Activity.- 10. Localization of Carbonic Anhydrase by Chemical Reactions.- 11. Localization of the Carbonic Anhydrases by Immunocyhemistry.- 12. Immunological Methods for Detection and Quantification of Carbonic Anhydrase Isozymes.- III. Carbonic Anhydrases in Clinical Medicine.- 13. Carbonic Anhydrase Inhibitors in Ophthalmology.- 14. The Eye: Topical Carbonic Anhydrase Inhibitors.- 15. Carbonic Anhydrase II Deficiency Syndrome: Clinical Delineation, Interpretation, and Implications.- IV. Genetic Regulation of the Carbonic Anhydrase Isozymes.- 16. The Structure and Regulation of the Human Carbonic Anhydrase I Gene.- 17. Expression of Carbonic Anhydrases I and II in Mouse Erythropoiesis.- 18. Structure and Expression of the Carbonic Anhydrase III Gene.- V. Muscle Carbonic Anhydrases.- 19. Muscle Carbonic Anhydrases: Function in Muscle Contraction and in the Homeostasis of Muscle pH and pCO2.- 20. Distribution and Ultrastructural Localization of Carbonic Anhydrase III in Different Skeletal Muscle Fiber Types.- 21. Hormonal and Neuronal Control of Carbonic Anhydrase III Gene Expression in Skeletal Muscle.- 22. Skeletal Muscle Mihondrial Carbonic Anhydrase: A Case of Species Specificity.- VI. Carbonic Anhydrases of the Gastrointestinal Tract.- 23. Distribution and Functions of Carbonic Anhydrase in the Gastrointestinal Tract.- 24. Hormonal Regulation and Localization of Rat Liver Carbonic Anhydrase.- 25. Liver Mihondrial Carbonic Anhydrase (CA V), Gluconeogenesis, and Ureagenesis in the Hepayte.- VII. The Carbonic Anhydrases of Other Organs.- 26. Function and Regulation of the Carbonic Anhydrases in the Vertebrate Neural Retina.- 27. Carbonic Anhydrase and Sensory Function in the Central Nervous System.- 28. Carbonic Anhydrase in Myelin and Glial Cells in the Mammalian Central Nervous System.- 29. Lung Carbonic Anhydrase.- 30. Carbonic Anhydrase and Chemoreception in Carotid and Aortic Bodies.- 31. Carbonic Anhydrases in the Kidney.- 32. Localization of Carbonic Anhydrase Isozymes in Calcified Tissues.- 33. Carbonic Anhydrase and Skeletogenesis.- 34. Carbonic Anhydrases Secreted in the Saliva.

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