The Cardiomyopathic Heart

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Proceedings of the symposium "Cellular Abnormalities Associated with Cardiomyopathies in Animals," held in Tokyo in May 1992 to provide a forum for experimental cardiologists and basic scientists to discuss problems related to heart dysfunction in cardiomyopathies. Since cardiomyopathic hamsters have been widely used as an experimental model of heart disease, Part I of this volume is devoted to hamster cardiomyopathy. Part II examines hypertrophic, congestive, and metabolic cardiomyopathies in different experimental models. Together, the contributions provide a comprehensive synthesis of recent advances in the physiology, pharmacology, and biochemistry of the cardiomyopathic heart. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780781700924
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 9/1/1993
  • Edition number: 1
  • Pages: 464

Table of Contents

1 Behavior of Subcellular Organelles during the Development of Congestive Heart Failure in Cardiomyopathic Hamsters (UM-X7.1) 1
2 Na, K ATPase Gene Expression in the Cardiomyopathic Heart
3 Alterations of Myocardial Contractility in Cardiomyopathic J-2-N Hamsters 23
4 Contractile and Regulatory Proteins in Hamster Cardiomyopathy 31
5 Sliding Velocity of Cardiomyopathic Hamster Cardiac Myosin on Nitellopsis Actin Cables: A Study Using an In Vitro Motility Assay 41
6 Altered Contractile Behavior of Cardiomyocytes from Cardiomyopathic Hamsters 49
7 Cardiac Collagen Expression in the Development of Two Types of Cardiomyopathic Hamsters (Bio 14.6 and Bio 53.58) 57
8 Pathophysiological Aspects of the Cardiomyopathic J-2-N Hamster 65
9 Status of [beta]-Adrenergic Mechanisms during the Development of Congestive Heart Failure in Cardiomyopathic Hamsters (UM-X7.1) 73
10 [beta]-Adrenergic and [12-[superscript 3]H]-Forskolin Binding Sites in the Hearts of Cardiomyopathic Bio 14.6 Syrian Hamsters 87
11 Decrease in Stimulatory Guanine Nucleotide-Binding Protein and Adenylate Cyclase Activities in Bio 14.6 Cardiomyopathic Hamsters 95
12 Inositolphosphatides Metabolism in the Cardiomyopathic Hamster 105
13 Alteration of 1,2-Diacylglycerol Content in Myopathic Hamster Hearts during the Development of Cardiomyopathy and Heart Failure 115
14 Electrocardiographic Changes during Progression and Following Treatment of Hamster Cardiomyopathy 125
15 Effect of Angiotensin-Converting Enzyme Inhibitor on Myocardial Collagen Metabolism in Cardiomyopathic Hamsters 137
16 Effects of an Angiotensin-Converting Enzyme Inhibitor, Cilazapril, on Congestive Heart Failure in Cardiomyopathic Hamsters 145
17 Effects of Angiotensin-Converting Enzyme Inhibitors and Prostaglandin E[subscript 1] Derivatives on Cardiomyopathic Hamsters 157
18 Role of Lipid Peroxidation in the Early Stage of Cardiomyopathy in the Bio 14.6 Syrian Hamster 165
19 Molsidomine, Isosorbide Dinitrate, and Antithrombotic Agents Do Not Prevent Cardiomyopathy in the Syrian Hamster 175
20 Subcellular Basis for Increased Diastolic Stiffness in Experimental Cardiomyopathies 185
21 Force-Frequency Relationship in the Nonfailing and End-Stage Failing Human Myocardium - Influence of Positive Inotropic Interventions 197
22 Myocardial Metabolic Derangement of Keshan Disease: A Noncoronary Myocardial Injury
23 Alterations of the Cardiac Sarcolemma in Keshan Disease Models and Their Pathogenic Significance as Compared with Those in Cardiomyopathic J-2-N Hamsters 223
24 Possible Stages of Adaptive Remodeling of Myocardial Cells 237
25 Vinculin-Containing Costameres: Parts of Contraction Forces Transmitting Sites of Cardiomyocytes 245
26 Metabolically Deranged Cardiomyopathy of the Trauma-Sepsis Syndrome 257
27 A Novel Animal Model of Alcoholic Cardiomyopathy 269
28 Doxirubicin-Induced Cardiomyopathy: A Model of Congestive Heart Failure 277
29 Cellular and Molecular Basis for the Immunopathologic Characteristics of the Myocardial Cell Damage Caused by Acute Viral Myocarditis, with Special Reference to Dilated Cardiomyopathy 285
30 Morphological Aspects of Experimental Autoimmune Myocarditis 293
31 Adoptive Transfer of Experimental Giant Cell Myocarditis into Normal Syngeneic Rats 299
32 Analysis of the Pathogenesis of Coxsackievirus B3 Myocarditis: Comparison of Myocarditic and Amyocarditic Coxsackievirus B3 Strains 309
33 Mutations of the Mitochondrial DNA in Patients with Hypertrophic Cardiomyopathy 313
34 Pulmonary Hypertension and Right Ventricular Hypertrophy in Rats 323
35 Effects of Monocrotaline-Induced Pulmonary Hypertension on Right Ventricular Hemodynamic, Biochemical, and Histologic Changes 335
36 Age-Dependent Differences in Cardiac Growth Response to Workload 345
37 Parallel Changes in the [beta]-Adrenoceptor/Adenylyl Cyclase System between the Failing Human Heart and the Noradrenaline-Treated Guinea Pig 361
38 Ontogenetic Development of Cardiotoxicity for Catecholamines 375
39 Isoproterenol-Induced Changes in Metabolic Regulations in the Canine Heart: Protective Effect of K[superscript +],Mg[superscript 2+]-Aspartate 383
40 Ontogenetic Differences in Isoproterenol-Induced [superscript 85]Sr Uptake in the Myocardium 395
41 Primary Stress Damage to the Heart 401
42 Dysfunction of Cardiac Sarcoplasmic Reticulum in the Diabetic Dog 419
43 Electron Microscopic and Endocrinologic Studies of Hypertrophic Hearts of Infants from Streptozotocin-Induced Diabetic Pregnant Rats 429
44 Involvement of the Parasympathetic Nervous System in Heart Mitochondrial Dysfunction Associated with Hypothyroidism in Rats 439
Index 449
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