The Challenge of Highly Pathogenic Microorganisms: Mechanisms of Virulence and Novel Medical Countermeasures / Edition 1

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This book addresses the unique features of four microorganisms that constitute the top bioterror threat agents: Bacillus anthracis; Yersinia pestis, Francisella tularensis and Orthopoxviruses. Side-by-side updated information about their pathogenisis, virulence and epidemiology is provided in a single volume, allowing for evaluation of common features as well as common strategies for defense. Classical microbiological as well as genomic, proteomic & transcriptomic approaches towards development of strategies of novel prophylactic and post-exposure treatment and related aspects of diagnostics and bioforensics are covered. Written by top scientists, this book will be of major interest to all researchers interested in the intricate biology of highly pathogenic microorganisms, to scientists and clinicians interested in microbial pathogenesis and prevention, and to a wide range of professionals dealing with the various aspects of bio-defense.

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Product Details

  • ISBN-13: 9789048190539
  • Publisher: Springer Netherlands
  • Publication date: 6/17/2010
  • Edition description: 2010
  • Edition number: 1
  • Pages: 314
  • Product dimensions: 6.20 (w) x 9.20 (h) x 0.90 (d)

Table of Contents

1 The Anthrax Capsule: Role in Pathogenesis and Target for Vaccines and Therapeutics Arthur M. Friedlander Friedlander, Arthur M. 1

2 Proteomic Studies of Bacillus anthracis Reveal In Vitro CO2-Modulation and Expression During Infection of Extracellular Proteases Avigdor Shafferman Shafferman, Avigdor 11

3 Dynamics of Bacillus anthracis Infection and Control Mechanisms Michele Mock Mock, Michele 23

4 Survival and Trafficking of Yersinia pestis in Non-acidified Phagosomes in Murine Macrophages James B. Bliska Bliska, James B. 31

5 The Inverse Relationship Between Cytotoxicity of Y. pestis and Its Virulence Ayelet Zauberman Zauberman, Ayelet 45

6 The NlpD Lipoprotein of Yersinia pestis is Essential for Cell Separation and Virulence Emanuelle Mamroud Mamroud, Emanuelle 57

7 Dissection of the Functions of the IglC Protein of Francisella tularensis Anders Sjostedt Sjostedt, Anders 67

8 Yersinia pestis Lipopolysacharide in Host-Pathogen Interactions Yuriy A. Knirel Knirel, Yuriy A. 77

9 The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonization Avigdor Shafferman Shafferman, Avigdor 89

10 Comparative Approaches to Identify Host Factors Specifically Targeted by Yersinia pestis During the Infectious Process Elisabeth Carniel Carniel, Elisabeth 99

11 Poxvirus Entry into Host Cells P.S. Satheskumar Satheskumar, P. S. 107

12 Role of A33R Amino-Acid 118L in the Interactions of Vaccinia Virus with the Host Udy Olshevsky Olshevsky, Udy 115

13 Inhibitors of Innate Immunity from Vaccinia Virus Geoffrey L. Smith Smith, Geoffrey L. 125

14 Brucella Species Synchronize Their Life Cycle to the Gestation Cycle of Their Ruminant Hosts Menachem Banai Banai, Menachem 135

15 MMP-9 as a Marker for Vaccinia Virus Related Encephalitis Nir Paran Paran, Nir 147

16 Epidemic Cowpox Virus Infections in Germany Andreas Nitsche Nitsche, Andreas 157

17 The Two Partner Secretion Transporters of Yersinia pestis: Cloning, Immunogenicity and In Vivo Expression Following Airway Infection Avigdor Shafferman Shafferman, Avigdor 165

18 Genetic Detection of Vesicle Forming Pathogens by Arrayed Primer Extension (APEX) Arie Ordentlich Ordentlich, Arie 173

19 Subtyping Biothreat Bacterial Pathogens Talima Pearson Pearson, Talima 183

20 A Rapid Method for Bacillus anthracis Genotyping Zeev Altboum Altboum, Zeev 191

21 Tularemia - A Disease with an Uncertain Impact on Public Health Herbert Nattermann Nattermann, Herbert 199

22 Consequences of Antibiotic Treatment of Francisella tularensis Airways Infections Avigdor Shafferman Shafferman, Avigdor 207

23 Novel Live Vaccine Candidates Against Airborne Francisella tularensis Anders Sjostedt Sjostedt, Anders 213

24 Effect of Disruption of mglA on the Virulence and Immunogenicity of the Francisella tularensis Live Vaccine Strain (LVS) Avigdor Shafferman Shafferman, Avigdor 219

25 Data Mining, Bioinformatic and Immunoinformatic Analyses of Francisella tularensis Schu S4 Genome in Search for Novel Vaccine Candidates Avigdor Shafferman Shafferman, Avigdor 229

26 Modified Vaccinia Virus Ankara (MVA) based Vaccines-Immunostimulatory and Protective Capacity Gerd Sutter Sutter, Gerd 245

27 Therapeutic Potential of Vaccinia Hyper Immune Sera in Mouse Models of Lethal Orthopoxviruses Infection Shlomo Lustig Lustig, Shlomo 253

28 A Live Plaque Vaccine Candidate with Improved Safety and Immunogenecity V.L. Motin Motin, V. L. 261

29 Protection Against Plague Afforded by Treatment with Polyclonal αLcrV and αF1 Antibodies Emanuelle Mamroud Mamroud, Emanuelle 269

30 Combination of Anthrax-Toxin Neutralizing Antibodies: Analysis of Synergism/Antagonism Effect Arie Ordentlich Ordentlich, Arie 275

31 The Efficacy of Antibiotic Treatment to Cure Guinea Pigs Intranasally Infected with Bacillus anthracis Spores David Kobiler Kobiler, David 287

32 Reverse Vaccinology in Bacillus anthracis Sara Cohen Cohen, Sara 295

Index 307

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