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The Chemotherapy Source Book

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The updated Third Edition of The Chemotherapy Source Book is the most current and comprehensive reference on cancer chemotherapy. It brings together pharmacologic and patient management information in one source that practitioners can consult for any question encountered in the delivery of chemotherapy.This edition features increased information on the expanding use of high-dose therapy for various cancers, including breast cancer, leukemias, multiple myeloma, Hodgkin's disease, non-Hodgkin's lymphoma, lung ...

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Overview

The updated Third Edition of The Chemotherapy Source Book is the most current and comprehensive reference on cancer chemotherapy. It brings together pharmacologic and patient management information in one source that practitioners can consult for any question encountered in the delivery of chemotherapy.This edition features increased information on the expanding use of high-dose therapy for various cancers, including breast cancer, leukemias, multiple myeloma, Hodgkin's disease, non-Hodgkin's lymphoma, lung cancer, and ovarian cancer. Coverage also includes new material on monoclonal antibodies, monoclonal antibody therapy, and breast, colon, and lung cancers, and information on five new drugs approved since the Second Edition.

A Brandon-Hill recommended title.

The book contains black-and-white illustrations.

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Editorial Reviews

Booknews
Intended for the practicing oncologist who will find a single-source reference on the subject convenient and useful. Sixty-eight contributions are grouped in sections on the principles of chemotherapy, chemotherapeutic drugs, management of drug toxicity, combination chemotherapy programs, drug administration, current therapy of specific solid tumors, and chemotherapy of hematologic malignancies. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780781723633
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 9/28/2001
  • Edition description: Third Edition
  • Edition number: 3
  • Pages: 1024

Table of Contents

Contributing Authors
Preface
Sect. I Principles of Chemotherapy
1 Scientific Basis of Cancer Chemotherapy 1
2 Antineoplastic Drug Development 6
3 Principles of Pharmacology 14
4 Norton-Simon Hypothesis 23
5 Drug Resistance 37
6 Adjuvant Chemotherapy 48
7 Combination Chemotherapy 69
8 Combined Modality Therapy 73
9 Design and Interpretation of Clinical Trials 81
10 Clinical Trials 89
11 Hematopoietic Growth Factors 94
12 Biologic Response Modifiers: Principles of Biotherapy 105
13 Circadian Timing of Cancer Chemotherapy 114
14 Intraventricular and Intrathecal Therapy 132
15 Intraperitoneal Chemotherapy 141
16 Continuous Intravenous Infusion Chemotherapy 144
17 Intraarterial Therapy 163
18 Perfusion Therapy 174
19 Hematopoietic Stem Cell Transplantation 185
Sect. II Chemotherapeutic Drugs
20 Covalent DNA-Binding Drugs 192
21 Antimetabolites 208
22 Antitumor Antibiotics and Related Compounds 227
23 Microtubule-Targeting Drugs 252
24 DNA Topoisomerase II Inhibitors 278
25 Topoisomerase I-Targeting Drugs 289
26 Differentiation Agents 304
27 Hormones 312
28 L-Asparaginase 323
29 Investigational Drugs 325
30 Antibodies 394
Sect. III Management of Drug Toxicity
31 Hematologic Complications of Cancer Chemotherapy 399
32 Oral Toxicity 406
33 Dermatologic Toxicity 424
34 Extravasation 432
35 Hypersensitivity Reactions 436
36 Ocular Side Effects of Chemotherapy 452
37 Cardiotoxicity of Chemotherapeutic Drugs 458
38 Chemotherapy-Associated Lung Injury 468
39 Gastrointestinal Complications of Chemotherapy 477
40 Hepatotoxicity of Chemotherapeutic Agents 483
41 Renal and Electrolyte Abnormalities Due to Chemotherapy 494
42 Neurotoxicity of Chemotherapy Agents 504
43 Vascular Toxicity 514
44 Second Malignancies after Chemotherapy 526
45 Chemotherapy in Pregnancy 537
46 Gonadal Complications and Teratogenicity of Cancer Therapy 546
Sect. IV Drug Administration
47 Central Venous Access for Chemotherapy 559
48 Risks of Handling Cytotoxic Drugs 566
49 Patient Education 583
Sect. V Current Therapy of Specific Solid Tumors
50 Chemotherapy of Melanoma 596
51 Chemotherapy of Primary Brain Tumors 602
52 Chemotherapy of Head and Neck Cancer 610
53 Chemotherapy of Lung Cancer 626
54 Chemotherapy of Breast Cancer 647
55 Chemotherapy of Gastrointestinal Cancer 689
56 Chemotherapy of Endocrine Tumors 698
57 Chemotherapy of Genitourinary Cancers 710
58 Chemotherapy of Gynecologic Cancer 732
59 Chemotherapy of Sarcomas of Bone and Soft Tissue 760
60 Chemotherapy of Carcinoma of Unknown Primary Site 778
61 Chemotherapy of Pediatric Solid Tumors 788
Sect. VI Chemotherapy of Hematologic Malignancies
62 Chemotherapy of Hodgkin's Disease 795
63 Chemotherapy of Non-Hodgkin's Lymphoma 810
64 Chemotherapy of Acute Leukemia in Adults 824
65 Chemotherapy and Immunotherapy of Chronic Lymphocytic Leukemia and Hairy Cell Leukemia 839
66 Chemotherapy of the Myelodysplastic Syndromes 849
67 Management of Chronic Myeloproliferative Disorders and Chronic Myelocytic Leukemia 857
68 Chemotherapy of Multiple Myeloma and Related Plasma Cell Dyscrasias 865
App Chemotherapy Programs 876
App Common Toxicity Criteria 905
Index 941
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