The Cholesterol Wars: The Skeptics vs the Preponderance of Evidence

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Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.

• Dr. Steinberg and his colleagues have published over 400 papers relating to lipid and lipoprotein metabolism and atherosclerosis reflecting the prominence these authors have in the community.
• Chronicles the miraculous power of the statins to prevent heart attacks and save lives, of great interest to the many manufacturers of these drugs
• Discusses new targets for intervention based on a better understanding of the molecular basis of atherosclerosis

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Editorial Reviews

Doody's Review Service
Reviewer: Chandra S. Bomma, M.D.(Ochsner Clinic Foundation)
Description: This is a very detailed chronological review of the conflicts among many professionals, including noble laureates and public health policy writers, in concluding cholesterol was one of the main guilty parties for atherosclerotic cardiovascular disease.
Purpose: This book summarizes events leading to the discovery of cholesterol and the evolution of the cholesterol hypothesis as one of the main culprits in the atherosclerotic cardiovascular diseases.
Audience: This will serve as an excellent source of knowledge for people in fields of medicine, health policy, and biomedical research as well as for the general public interested in preventive health.
Features: The book details the events and the eminent people involved in the research of animal models of atherosclerosis, hypercholesterolemia, and its role in atherosclerosis in humans, cholesterol metabolism, the search for cholesterol lowering drugs, and the coronary primary prevention trials. It also describes the events around the uphill battles fought against the theories that almost succeeded in acquitting cholesterol as a causative factor for atherosclerotic disease. Very good schematics, micrographs, and references support the data presented in the book.
Assessment: Cholesterol was categorically proven to be one of the main culprits in atherosclerosis, thereby increasing cardiovascular morbidity and mortality. This book is a long overdue work to honor all the individuals involved in the field of atherosclerotic cardiovascular disease.
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Product Details

  • ISBN-13: 9780123739797
  • Publisher: Elsevier Science
  • Publication date: 9/24/2007
  • Pages: 248
  • Product dimensions: 6.45 (w) x 9.11 (h) x 0.79 (d)

Table of Contents

Thoughts on the Nature of Medical Controversy in General and an Overview of the Cholesterol Controversy in Particular
Animal Models of Atherosclerosis
Early Evidence Linking Hypercholesterolemia to Atherosclerosis and Coronary Heart Disease
Lipoproteins and Metabolism
In Search of a Pathogenesis
Basic Science Foundations
Searching for Drugs that would Lower Blood Cholesterol Safely and Effectively
1984 Coronary Primary Prevention Trial
A Look at the Future

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