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Doody's Review ServiceReviewer: Chandra S. Bomma, M.D.(Ochsner Clinic Foundation)
Description: This is a very detailed chronological review of the conflicts among many professionals, including noble laureates and public health policy writers, in concluding cholesterol was one of the main guilty parties for atherosclerotic cardiovascular disease.
Purpose: This book summarizes events leading to the discovery of cholesterol and the evolution of the cholesterol hypothesis as one of the main culprits in the atherosclerotic cardiovascular diseases.
Audience: This will serve as an excellent source of knowledge for people in fields of medicine, health policy, and biomedical research as well as for the general public interested in preventive health.
Features: The book details the events and the eminent people involved in the research of animal models of atherosclerosis, hypercholesterolemia, and its role in atherosclerosis in humans, cholesterol metabolism, the search for cholesterol lowering drugs, and the coronary primary prevention trials. It also describes the events around the uphill battles fought against the theories that almost succeeded in acquitting cholesterol as a causative factor for atherosclerotic disease. Very good schematics, micrographs, and references support the data presented in the book.
Assessment: Cholesterol was categorically proven to be one of the main culprits in atherosclerosis, thereby increasing cardiovascular morbidity and mortality. This book is a long overdue work to honor all the individuals involved in the field of atherosclerotic cardiovascular disease.