The Cytoskeleton
The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins.

This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.
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The Cytoskeleton
The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins.

This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.
135.0 In Stock
The Cytoskeleton

The Cytoskeleton

The Cytoskeleton

The Cytoskeleton

Hardcover

$135.00 
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Overview

The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins.

This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.

Product Details

ISBN-13: 9781621820161
Publisher: Cold Spring Harbor Laboratory Press
Publication date: 12/31/2016
Pages: 391
Product dimensions: 8.80(w) x 11.10(h) x 3.00(d)

Table of Contents

Preface

1. Overview of the Cytoskeleton from an Evolutionary Perspective
Thomas D. Pollard and Robert D. Goldman

PART 1. CYTOSKELETAL AND MOTILITY PROTEINS
2. Actin and Actin-Binding Proteins
Thomas D. Pollard
3. Microtubules and Microtubule-Associated Proteins
Holly V. Goodson and Erin M. Jonasson
4. Intermediate Filaments: Structure and Assembly
Harald Herrmann and Ueli Aebi
5. Motor Proteins
H. Lee Sweeney and Erika L.F. Holzbaur
6. Cytoskeleton Integrators: The Spectrin Superfamily
Ronald K.H. Liem

PART 2. CYTOSKELETON IN CELL AND TISSUE ARCHITECTURE
7. Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells
Alexia I. Bachir, Alan Rick Horwitz, W. James Nelson, and Julie M. Bianchini
8. The Centrosome, a Multitalented Renaissance Organelle
Anastassiia Vertii, Heidi Hehnly, and Stephen Doxsey
9. Types I and II Keratin Intermediate Filaments
Justin T. Jacob, Pierre A. Coulombe, Raymond Kwan, and M. Bishr Omary
10. Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin
Elly M. Hol and Yassemi Capetanaki
11. Neurofilaments and Neurofilament Proteins in Health and Disease
Aidong Yuan, Mala V. Rao, Veeranna, and Ralph A. Nixon
12. Intermediate Filaments and the Plasma Membrane
Jonathan C.R. Jones, Chen Yuan Kam, Robert M. Harmon, Alexandra V. Woychek, Susan B. Hopkinson, and Kathleen J. Green
13. The Nucleoskeleton
Stephen A. Adam
14. Mechanical Properties of the Cytoskeleton and Cells
Adrian F. Pegoraro, Paul Janmey, and David A. Weitz

PART 3. INTRACELLULAR TRANSPORT
15. Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles
Kari Barlan and Vladimir I. Gelfand
16. Intraflagellar Transport and Ciliary Dynamics
Hiroaki Ishikawa and Wallace F. Marshall
17. Intracellular Motility of Intermediate Filaments
Rudolf E. Leube, Marcin Moch, and Reinhard Windoffer
18. Myosin-Driven Intracellular Transport
Margaret A. Titus

PART 4. CELLULAR MOTILITY
19. The Actin Cytoskeleton and Actin-Based Motility
Tatyana Svitkina
20. Muscle Contraction
H. Lee Sweeney and David W. Hammers
21. Ciliary Motility: Regulation of Axonemal Dynein Motors
Rasagnya Viswanadha, Winfield S. Sale, and Mary E. Porter
22. Intermediate Filaments and the Regulation of Cell Motility during Regeneration and Wound Healing
Fang Cheng and John E. Eriksson

PART 5. CELL DIVISION
23. Mitosis
J. Richard Mcintosh
24. Cytokinesis in Metazoa and Fungi
Michael Glotzer

Index
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