The Drunken Synapse: Studies of Alcohol-Related Disorders

Overview

This volume is divided into three sections: synaptic transmission, synaptic modulation, and synaptic plasticity. Some of the topics covered include: molecular targets underlying ethanol-mediated reduction of hormone release from neurohypophysial nerve terminals; alcohol and general anesthetic modulation of GABAA and neuronal nicotinic acetylcholine receptors; alcohol and the 5-HT3 receptor, adenosine and ethanol; metabotropic hypothesis for ethanol sensitivity of GABAergic and glutamatergic central synapses; ...
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Overview

This volume is divided into three sections: synaptic transmission, synaptic modulation, and synaptic plasticity. Some of the topics covered include: molecular targets underlying ethanol-mediated reduction of hormone release from neurohypophysial nerve terminals; alcohol and general anesthetic modulation of GABAA and neuronal nicotinic acetylcholine receptors; alcohol and the 5-HT3 receptor, adenosine and ethanol; metabotropic hypothesis for ethanol sensitivity of GABAergic and glutamatergic central synapses; alcohol, memory, and molecules; novel forms and analyses of ethanol effects on synaptic plasticity; and ethanol suppression of hippocampal plasticity.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Konstantin V. Slavin, MD (University of Illinois at Chicago College of Medicine)
Description: The exact mechanisms by which ethanol alters behavior are unknown, but this subject is a topic of active research in many laboratories and clinical centers. This book includes proceedings of a special symposium on studies of synaptic function in various alcohol-related disorders.
Purpose: The purpose is to summarize the latest research on the actions of ethanol on the synapse. With increasing interest focused on the alcohol problem, and further deepening of our knowledge about mechanisms of alcohol effects, this topic is both important and interesting.
Audience: The book is aimed at neuroscientists that deal with synapses and neurochemistry. Behavioral researchers and alcoholism investigators may also find it useful as both a reference source and scientific update. Contributors to the book are scientists from 15 academic centers in the U.S.
Features: The unique feature of the book is that in addition to the symposium proceedings, the editors put together several chapters based on discussions between the audience and the speakers. These discussions add to the understanding of the text and sometimes bring up certain questions that require additional explanations. Reading through the scientific exchanges gives readers an impression of actually being present at the symposium.
Assessment: This book is dedicated to a very specific topic in neuroscience — the effect of alcohol on neuronal synapses and their activity (transmission, modulation, and plasticity). The editors did a great job organizing the symposium on this topic and putting together a comprehensive overview of current concepts in the field of alcohol-related synaptic studies. This aspect of neurobiology is rapidly gaining more attention and this book may become a beginning of a new series on the molecular and physiological effects of alcohol.
Konstantin V. Slavin
The exact mechanisms by which ethanol alters behavior are unknown, but this subject is a topic of active research in many laboratories and clinical centers. This book includes proceedings of a special symposium on studies of synaptic function in various alcohol-related disorders. The purpose is to summarize the latest research on the actions of ethanol on the synapse. With increasing interest focused on the alcohol problem, and further deepening of our knowledge about mechanisms of alcohol effects, this topic is both important and interesting. The book is aimed at neuroscientists that deal with synapses and neurochemistry. Behavioral researchers and alcoholism investigators may also find it useful as both a reference source and scientific update. Contributors to the book are scientists from 15 academic centers in the U.S. The unique feature of the book is that in addition to the symposium proceedings, the editors put together several chapters based on discussions between the audience and the speakers. These discussions add to the understanding of the text and sometimes bring up certain questions that require additional explanations. Reading through the scientific exchanges gives readers an impression of actually being present at the symposium. This book is dedicated to a very specific topic in neuroscience -- the effect of alcohol on neuronal synapses and their activity (transmission, modulation, and plasticity). The editors did a great job organizing the symposium on this topic and putting together a comprehensive overview of current concepts in the field of alcohol-related synaptic studies. This aspect of neurobiology is rapidly gaining more attention and this book may become abeginning of a new series on the molecular and physiological effects of alcohol.
Booknews
This book represents the entire proceedings of The National Institute on Alcohol Abuse and Alcoholism's NIAAA October 1997 symposium regarding the latest research on the effects of ethanol on the synapse, not only transcripts of the presentations, but also of the questions and discussions that followed. The symposium, organized into three sessions: synaptic transmission, synaptic modulation, and synaptic plasticity, covered topics such as molecular targets underlying ethanol-mediated reduction of hormone release from neurohypophysical nerve terminals; the effect of caffeine in the actions of ethanol; and ethanol suppression of hippocampal plasticity. Annotation c. Book News, Inc., Portland, OR booknews.com

3 Stars from Doody
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Product Details

  • ISBN-13: 9780306461118
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 5/28/1999
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 219

Table of Contents

List of Contributors. Preface. 1. Overview of the Symposium; W.A. Hunt, Yuan Liu. 2. A Perspective on the Synapse; G.M. Shepherd. Section I: Synaptic Transmission. 3. Molecular Targets Underlying Ethanol-Mediated Reduction of Hormone Release From Neurohypophysial Nerve Terminals; S.N. Treistman, et al. 4. Alcohol and General Anesthetic Modulation of GABAA and Neuronal Nicotinic Acetylcholine Receptors; T. Narahashi, et al. 5. Alcohol and the 5-HT3 Receptor; D.M. Lovinger, Qing Zhou. 6. Questions and Answers of Session I - Synaptic Transmission; Yuan Liu, W.A. Hunt. (eds.) Section II: Synaptic Modulation. 7. Depolarization-Induced Suppression of Inhibition (DSI) Involves a Retrograde Signaling Process that Regulates GABAA-Mediated Synaptic Responses in Mammalian CNS; B.A. Alger. 8. Native GABAA Receptors Get 'Drunk' but not Their Recombinant Counterparts; H.H. Yeh, D.W. Sapp. 9. Adenosine and Ethanol: Is There a Caffeine Connection in the Actions of Ethanol? T.V. Dunwiddie. 10. A Metabotropic Hypothesis for Ethanol Sensitivity of GABAergic and Glutamatergic Central Synapses; G.R. Siggins, et al. 11. Questions and Answers of Session II - Synaptic Modulation; Yuan Liu, W.A. Hunt. (eds.) Section III: Synaptic Plasticity. 12. Alcohol, Memory and Molecules; M. Browning, et al. 13. Of Mice and Minis: Novel Forms and Analyses of Ethanol Effects on Synaptic Plasticity; R.A. Morrisett, M.P. Thomas. 14. Ethanol Suppression of Hippocampal Plasticity: Role of Subcortical Inputs; S.C. Steffensen. 15. Questions and Answers of Session III &endash; Synaptic Plasticity; Yuan Liu, W.A. Hunt. (eds.)
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