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The Flaviviruses: Structure, Replication and Evolution
     

The Flaviviruses: Structure, Replication and Evolution

by Karl Maramorosch
 

ISBN-10: 0120398591

ISBN-13: 9780120398591

Pub. Date: 12/24/2003

Publisher: Elsevier Science

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.

Structure, Replication and

Overview

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.

Structure, Replication and Evolution is the first volume of The Flaviviruses and presents the latest research covering the conceptual advances on aspects such as the characterization of virus structure, cellular receptors, mechanisms of virus entry, host and viral components of the RNA replicase.

• Includes new, detailed information on the evolution, viral structure and replication of the Flavivirus family
• The only complete reference book on a major virus family
• Descibes the technologies that have contributed to our current knowledge about Flaviviruses
• Identifies the major problems faced in understanding the virus-host interactions that result in disease

Product Details

ISBN-13:
9780120398591
Publisher:
Elsevier Science
Publication date:
12/24/2003
Series:
Advances in Virus Research Series
Pages:
369
Product dimensions:
1.06(w) x 6.00(h) x 9.00(d)

Table of Contents

Taxonomy of the virus family Flaviviridae
Structure and replication
Molecular Biology of the Flaviviruses
Flavivirus Structure and Membrane Fusion
Kunjin RNA replication and applications of Kunjin replicons
Antigenic structure of flavivirus Proteins
5' and 3' non-coding regions in flavivirus RNA
Manipulation of Cell Surface Macromolecules by Flaviviruses
Flavivirus evolution
Origins, Evolution and vecto/host cp-adaptations within the genus Flavivirus
Microevolution and virulence of dengue viruses

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