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Doody's Review ServiceReviewer: Boris Pasche, MD, PhD (Northwestern University Feinberg School of Medicine)
Description: Given the rapid evolution of cancer genetics this second edition is a welcome update for the community of physicians and scientists working in the field.
Purpose: The purpose is to present a thorough review of the mechanisms involved in the acquisition of mutations during cancer development and progression.
Audience: This book is intended for physicians and scientists interested in cancer genetics. The level of depth found throughout makes it more suitable for scientists than for clinicians. Both editors have greatly contributed to the field and are undisputed authorities.
Features: The first part of the book covers basic concept in cancer genetics such as the nature and mechanisms of human gene mutations, genomic imprinting in cancer, and tumor genomic instability. A new chapter is devoted to gene expression profiling in cancer. There is a brief review of cell cycle and its impact on tumor development and progression. Familial cancer syndromes are reviewed in detail and the last part of the book is devoted to the analysis of cancer genetic abnormalities specific to a variety of cancers.
Assessment: This book is written by the foremost experts in cancer genetics and is a reference for anyone who desires to become familiar with the latest advances in the field. It is unique because of its focus on cancer genetics. Publication of a second edition was clearly warranted by the rapid progress made in the past few years.