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The Genetic Basis of Human Cancer

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Reveals what leading experts have recently discovered about cancers caused by DNA alterations!

The second edition of THE GENETICS OF CANCER, newly titled THE GENETIC BASIS OF HUMAN CANCERS, updates and informs on the most recent progress in genetic cancer research and its impact on patient care. With contributions by the foremost authorities in the field, this fascinating new edition reports on how to ...

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Overview

Reveals what leading experts have recently discovered about cancers caused by DNA alterations!

The second edition of THE GENETICS OF CANCER, newly titled THE GENETIC BASIS OF HUMAN CANCERS, updates and informs on the most recent progress in genetic cancer research and its impact on patient care. With contributions by the foremost authorities in the field, this fascinating new edition reports on how to understand and predict tumor development - information that can enhance decision-making and advance genetic research.

2ND Edition Highlights

NEW CHAPTERS:
* Peutz-Jeghers syndrome
* Juvenile polyposis syndrome
* Tumor genome instability
* Gene expression profiling in cancer
* Pilomatricoma and pilomatrix carcinoma
* Hereditary paragangliomas of the head and neck
* Cylindromatosis
* Familial cardiac myxomas and carney complex
* Cancers of the oral cavity and pharynx
* Genetic abnormalities in lymphoid malignancies

THOROUGHLY REVISED:
* Every chapter has been meticulously reviewed and revised to incorporate the most recent research and clinical findings
* Includes a valuable introduction by renowned editors Vogelstein & Kinser
* Features 150 MORE illustrations than the previous edition

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Editorial Reviews

Doody's Review Service
Reviewer: Boris Pasche, MD, PhD (Northwestern University Feinberg School of Medicine)
Description: Given the rapid evolution of cancer genetics this second edition is a welcome update for the community of physicians and scientists working in the field.
Purpose: The purpose is to present a thorough review of the mechanisms involved in the acquisition of mutations during cancer development and progression.
Audience: This book is intended for physicians and scientists interested in cancer genetics. The level of depth found throughout makes it more suitable for scientists than for clinicians. Both editors have greatly contributed to the field and are undisputed authorities.
Features: The first part of the book covers basic concept in cancer genetics such as the nature and mechanisms of human gene mutations, genomic imprinting in cancer, and tumor genomic instability. A new chapter is devoted to gene expression profiling in cancer. There is a brief review of cell cycle and its impact on tumor development and progression. Familial cancer syndromes are reviewed in detail and the last part of the book is devoted to the analysis of cancer genetic abnormalities specific to a variety of cancers.
Assessment: This book is written by the foremost experts in cancer genetics and is a reference for anyone who desires to become familiar with the latest advances in the field. It is unique because of its focus on cancer genetics. Publication of a second edition was clearly warranted by the rapid progress made in the past few years.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780070675964
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 12/1/1997
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 731
  • Product dimensions: 8.79 (w) x 11.32 (h) x 1.26 (d)

Table of Contents

Contributors
Pt. 1 Basic Concepts in Cancer Genetics
1 Introduction 3
2 The Nature and Mechanisms of Human Gene Mutation 7
3 Genomic Imprinting and Cancer 43
4 Genes Altered by Chromosomal Translocations in Leukemia and Lymphomas 57
5 Chromosome Alterations in Human Solid Tumors 93
6 Gene Amplification in Human Cancers: Biological and Clinical Significance 115
7 Tumor Genome Instability 129
8 Gene Expression Profiling in Cancer 131
Pt. 2 Controls on Cell Cycle
9 Cell Cycle Control: An Overview 145
10 Apoptosis and Cancer 163
11 Oncogenes 177
12 Tumor-Suppressor Genes 197
Pt. 3 Familial Cancer Syndromes
13 Familial Cancer Syndromes: Role of Caretakers and Gatekeepers 209
14 Nucleotide Excision Repair Syndromes: Xeroderma Pigmentosum, Cockayne Syndrome, and Trichothiodystrophy 211
15 Ataxia-Telangiectasia 239
16 Bloom Syndrome 267
17 Fanconi Anemia 289
18 Hereditary Nonpolyposis Colorectal Cancer (HNPCC) 307
19 Werner Syndrome 323
20 Peutz-Jeghers Syndrome 337
21 Juvenile Polyposis Syndrome 343
22 Retinoblastoma 357
23 Li-Fraumeni Syndrome 387
24 Wilms Tumor 403
25 Neurofibromatosis 1 417
26 Neurofibromatosis 2 439
27 Renal Carcinoma 449
28 Multiple Endocrine Neoplasia Type 1 475
29 Multiple Endocrine Neoplasia Type 2 501
30 Malignant Melanoma 515
31 Cowden Syndrome 527
32 Skin Cancer (Including Nevoid Basal Cell Carcinoma Syndrome) 529
33 Breast Cancer 549
34 Colorectal Tumors 583
35 Pilomatricoma and Pilomatrix Carcinoma 613
36 Hereditary Paragangliomas of the Head and Neck 621
37 Cylindromatosis 629
38 Familial Cardiac Myxomas and Carney Complex 635
39 Genetic Testing for Familial Cancer 643
Pt. 4 Cancer by Site
40 Pancreatic Cancer 659
41 Ovarian Cancer 675
42 Endometrial Cancer 681
43 Cervical Cancer 689
44 Bladder Cancer 697
45 Stomach Cancer 703
46 Prostate Cancer 709
47 Brain Tumors 719
48 Lung Cancer 731
49 Hepatocellular Carcinoma 741
50 Clinical and Biological Aspects of Neuroblastoma 751
51 Cancers of the Oral Cavity and Pharynx 733
52 Genetic Abnormalities in Lymphoid Malignancies 785
Index 803
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