The Genetics of Cancer: Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation / Edition 1

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Overview

An understanding of the genetic basis of cancer and the mechanisms governing cancer invasion and its secondary spread are fundamental to our ability to design appropriate treatments.
This book, written by internationally recognised experts in cancer biology, provides insights into the deregulation of the cell cycle in tumour development and integrates the function of tumour suppressor genes, oncogenes and metastasis-associated genes in the pathogenesis and progression of cancer.
This volume presents an up to date and comprehensive coverage of current research in the field.
The contents include:
* Clonal evolution of the metastasis phenotype
* Cell Cycle regulation
* Apoptosis in tumour growth and metastasis
* Angiogenesis in cancer
* Cell surface glycoproteins and their receptors
* Proteinases and their inhibitors in cancer invasion
* Oncogenes and cancer metastasis
* Developmental genes
* Tumour suppressor genes
* Metastasis suppressor genes
* Dominant metastasis-associated genes
This book will be of interest to all graduates, clinicians and researchers working in the fields of cancer biology, genetics and molecular biology.

Audience: Graduates, research scientists, and research clinicians in cancer biology, oncology, pathology, genetics, molecular biology, and biomedicine in general.

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Editorial Reviews

From the Publisher
"Overall this book provides an excellent and often critical overview of the current state of knowledge of the genes associated with invasion and metastasis and those processes associated with it. It is a very good source of references for seminal papers and reviews, which are quite comprehensive...it will make a very useful and readable introduction to the genetics of tumor invasion and metastasis and to the concepts that underlie it."
--PATHOLOGY
"The book's greatest strength is in compiling and extensively referencing the massive and often paradoxical clinical literature correlating the expression patterns of cancer genes with different tumor phenotypes."
--NATURE MEDICINE
Booknews
For graduates, clinicians, and researchers working in cancer biology, genetics, or molecular biology, researchers from the University of Newcastle upon Tyne report on the current knowledge about the genetic basis of cancer and the mechanisms governing its invasion and secondary spread. They offer insights into the deregulation of the cell cycle in tumor development and integrate the functional of tumor suppressor genes, oncogenes, and genes associated with metastasis in the pathogenesis and progression of cancer. The bibliography is 120 pages long. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780126398755
  • Publisher: Elsevier Science
  • Publication date: 7/11/1997
  • Edition number: 1
  • Pages: 338
  • Product dimensions: 0.88 (w) x 6.14 (h) x 9.21 (d)

Meet the Author

Dr. G.V. Sherbet is DSc (Doctor of Science) London University; FRCPath (Fellow of the Royal College of Pathologists). He was a member of the scientific staff at the Chester Beatty Research Institute and University College Medical School of London, and Deputy Director of the Cancer Research Unit in the Medical School of University of Newcastle upon Tyne. He has held several prestigious fellowships, such as the Beit Memorial and the Williams and Cancer Research Campaign fellowships. Dr Sherbet is Adjunct professor at the Institute for Molecular Medicine Huntington Beach CA. He is on the editorial boards of many international scientific and medical journals.

Dr. M.S. Lakshmi has held academic appointments at Johns Hopkins University in Baltimore, Harvard University, University of Bonn as Alexander von Humboldt Fellow, University of Edinburgh, Chester Beatty Research Institute in London, University of Nottingham in the Cancer Research Campaign Laboratories, and University College Medical School in London. She is presently a senior research scientist in the Cancer Research Unit at the University of Newcastle upon Tyne.

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Table of Contents

Preface.
Acknowledgement.
Introduction.
Clonal Evolution of Metastasis.
Inefficiency of the Metastatic Process.
Tumor Growth and Metastatic Potential.
Cell Cycle Regulation and Metastasis.
Apoptosis in Tumor Growth and Metastasis.
Angiogenesis in Cancer.
Cell Surface Glycoproteins and Their Receptors.
Proteinases and Their Inhibitors in Cancer Invasion.
Oncogenes and Cancer Metastasis.
Developmental Genes and Their Putative Tumor Suppressor Function.
Tumor Suppressor Genes.
Metastasis Suppressor Genes.
Dominant Metastasis Associated Genes.
Epilogue.
References.
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