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The Heart in Systemic Autoimmune Diseases
     

The Heart in Systemic Autoimmune Diseases

by Andrea Dorea, Ronald A. Asherson, Andrea Doria
 

ISBN-10: 0444513981

ISBN-13: 9780444513984

Pub. Date: 02/03/2004

Publisher: Elsevier Science

This first volume represents the state-of-the-art in the field of cardiovascular disease and autoimmune rheumatic diseases. Systemic autoimmune diseases comprise a family of conditions that share common pathogenetic mechanisms as well as a multi-organ involvement including the heart. This volume has been subdivided into three parts. In the first part, the immune

Overview

This first volume represents the state-of-the-art in the field of cardiovascular disease and autoimmune rheumatic diseases. Systemic autoimmune diseases comprise a family of conditions that share common pathogenetic mechanisms as well as a multi-organ involvement including the heart. This volume has been subdivided into three parts. In the first part, the immune mechanisms involved in cardiac damage have been considered. The role of proinflammatory and regulatory cytokines in driving an autoimmune response to cardiac self-tissues has been analysed. Moreover, the prevalence, the clinical meaning and the hypothetical pathogenicity of a broad spectrum of organ and non-organ specific autoantibodies have been discussed in detail. In the second part of the volume, the role of humoral and innate immunity in promoting the development of atherosclerotic plaque has been extensively reviewed, along with the newly discovered anti-inflammatory properties of statins. These two parts of the volume deal with exciting aspects of this topic, suggesting a very close connection between heart diseases and immunology. Finally, in the third part, the cardiac manifestations observed in the major systemic autoimmune conditions have been comprehensively examined.

This book yields an impressive body of well ordered information, highlighting key references and summarising the experience of a selected panel of distinguished physician-scientists actively involved in the field of cardiovascular disease and systemic autoimmunity.

Product Details

ISBN-13:
9780444513984
Publisher:
Elsevier Science
Publication date:
02/03/2004
Series:
Handbook of Systemic Autoimmune Diseases Series , #1
Pages:
276
Product dimensions:
7.70(w) x 10.50(h) x 0.70(d)

Table of Contents

Part I. Immune and autoimmune mechanisms involved in cardiac damage.
Cellular immunity: A role for cytokines (D-L.Fearweather, M. Afanasyeva, N.R. Rose). Humoral immunity: Organ-specific autoimmunity involvement in cardiovascular disease (A.L.P. Caforio, F. Tona, W.J. McKenna). Humoral immunity: Non-organ specific autoimmunity (P. Riboldi, M. Gerosa et al.). Pathogenesis of Anti-SSA/Ro-SSB/La associated congenital heart block (R.M. Clancy, J.P. Buyon).

Part II. Immune mechanisms involved in atherosclerosis.
Innate immunity, inflammation, and atherogenesis (M. Rattazzi, Y. Shoenfeld, P. Pauletto). Atherosclerosis and autoimmunity (Y. Sherer, Y. Shoenfeld). Statins and autoimmunity (V.S. Gurevich).

Part III. Cardiac involvement in autoimmune connective tissue diseases.
Cardiac imaging techniques in systemic autoimmune diseases (M. Turiel, P. Sarzi-Puttini, R. Cervera). Cardiac involvement in rheumatoid arthritis (N.T. Goodson). Cardiac involvement in systemic lupus erythematosus (A. Doria, M. Petri). Neonatal lupus syndrome: clinical features (A. Brucato, J. Buyon). The heart in scleroderma (G. Coghlan, C. Denton). Autoimmune myositis and overlap syndrome (I. Lundberg). Cardiac involvement in the antiphospholipid syndrome (D.
Erkan, M. Roman et al.). Vasculitis (C. Pagnoux, L. Boiardi et al.).

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