Human Frontal Lobes, Second Edition: Functions and Disorders

Human Frontal Lobes, Second Edition: Functions and Disorders

by Bruce L. Miller

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Now in a revised and expanded second edition, this authoritative work synthesizes the rapidly growing knowledge base on the human frontal lobes and their central role in behavior, cognition, health, and disease. Leading contributors address neuroanatomy, neurochemistry, and normal neuropsychological functioning, and describe the nature and consequences of frontal lobe


Now in a revised and expanded second edition, this authoritative work synthesizes the rapidly growing knowledge base on the human frontal lobes and their central role in behavior, cognition, health, and disease. Leading contributors address neuroanatomy, neurochemistry, and normal neuropsychological functioning, and describe the nature and consequences of frontal lobe dysfunction in specific neurological and psychiatric conditions. Second edition features include a new section on structural and functional neuroimaging and substantially expanded coverage of frontotemporal dementia and related disorders. Other new topics include self-consciousness, competence, and personality; new testing approaches; bipolar disorder; and adult-onset genetic disorders of the frontal lobes. The book is illustrated with nearly 100 figures.

Editorial Reviews

3 Stars from Doody
Nestor M. Ivkov
This is a monograph on the human frontal lobes. It presents both scientific foundations of neuropsychology and clinical neurology, and neuropsychiatry and neuropsychology in a thorough way. This book represents the state of the art in current frontal lobe research. It is dedicated to neuropsychiatrists and neuropsychologists, as well as neurologists and researchers in the field of neuroscience. All the basic sciences relevant to the CNS research have been covered well in this book. These include anthropology, genetics, and even philosophy to some extent. Detailed physiology of the frontal lobe and its correlating clinical pathology are provided. A discussion of the evolution of the frontal lobes is very impressive; its conclusions are far reaching. The graphics are somewhat too simple. This first book in a new series brings a very comprehensive review of the state of the art in frontal lobe neuroscience. Intellectually challenging, it presents various aspects of a big mystery called the frontal lobe. We are still far away from the answers to the questions asked in this book, but I am pretty sure we will have an updated edition of it very soon.
This is the first volume in a new series intended for scientists and practitioners in all the disciplines that address brain-behavior relationships. Providing a contemporary summary of recent advances in frontal lobe structure and function in health and disease, 34 contributions are grouped in sections on frontal lobe neuroanatomy, neurochemistry and neurophysiology, neuropsychological functions, and diseases of the frontal lobes (neurologic and psychiatric). Authors include clinicians, scientists, psychiatrists, and cognitive psychobiologists. Annotation c. by Book News, Inc., Portland, Or.
Doody's Review Service
Reviewer: Christopher J Graver, PhD, ABPP-CN(Madigan Healthcare System)
Description: This is the second edition of a book devoted to understanding the human frontal lobes from the perspectives of basic and clinical science.
Purpose: The book brings together an outstanding group of researchers to update our current knowledge of the anatomy, behavioral functioning, and disease states of the frontal lobes. The first edition was published in 1998 and much has been learned since then through new techniques and expanding research.
Audience: This would be appropriate for neurologists, neuropsychologists, and neuroscientists. The editors have done extensive research in this field and the contributing authors bring critical knowledge to this book.
Features: Major sections cover the anatomy of the frontal lobes and frontal lobe circuits, neurochemistry, neuroimaging, neuropsychology, and neurological and psychiatric diseases. The chapters are well integrated into the overarching theme of the book and a consistent, but not tedious, structure is maintained across chapters. The chapters are informative and manage to summarize copious information. Charts, illustrations, photographs of gross anatomy, and neuroimaging slides enhance the pedagogic quality of the text. The basic science is supplemented by clinical applications of this knowledge (e.g., neurological and neuropsychological assessment). The unfortunate oversight in the second edition is the scarcity of updated references. While there are references that are more current than 1998, many of them are still 5-7 years old. In this edition, some sections have been expanded, while other sections have unfortunately been pruned (e.g., the section on psychiatric diseases and the chapter regarding decision-making and research participation).
Assessment: It would take days to track down the information contained in just one of this book's chapters, making the compilation of this information in a single text invaluable. The careful inclusion of multidisciplinary perspectives makes this a must-have text for anyone involved in the neurosciences. This is one of those rare books that readers will appreciate from the first chapter to the last.
From the Publisher
"A well-written and comprehensive text from two eminent clinical neuroscientists. In keeping with a tradition of excellence, this second edition expands on the editors' highly successful first edition. A historical and conceptual overview has been added, as well as a new section on imaging that includes contributions from foremost experts. Advances in the understanding of frontotemporal dementia are also reflected in chapters emphasizing the importance of this previously understudied disease. This text is a 'must read' for anyone seriously interested in understanding the biology of behavior and the diseases that cause it to go awry."—Charles DeCarli, MD, Department of Neurology and Center for Neuroscience, University of California, Davis

"Few areas of the brain have attracted more research than the frontal lobes. Once considered esoteric, frontal lobe disease is now a common diagnosis in patients with neurodegenerative dementias. This updated second edition, edited by two prominent leaders in behavioral and cognitive neurology, contains a thoughtfully integrated exploration of frontal lobe neuroanatomy, neurochemistry, imaging, and neuropsychology. The contributors include some of the most productive clinicians and scientists in the field. Drs. Miller and Cummings have edited a volume that deserves to become the standard reference work on the human frontal lobes."—Marsel Mesulam, MD, Cognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Northwestern University

"This second edition provides the perfect framework for further integrating neurology, psychiatry, and neuropsychology in the understanding and treatment of major mental disorders. A great breadth of scientific knowledge, clinical acumen, and provocative analysis is brought to bear on enigmatic frontal lobe syndromes. Detailed and comprehensive, this is a vital reference for practitioners, investigators, and students who wish to be at the cutting edge of clinical neuroscience and multidisciplinary research."—Paul J. Eslinger, PhD, Penn State Hershey Medical Center

Journal of the International Neuropsychological Society
"The introductory sections of the text illustrate the breadth of knowledge of the editors....This revised text has successfully managed to capture the significant advances since original publication almost a decade ago. It has adopted a strongly evidence-based model to inform the reader of key concepts in the neurosciences and their relationship to clinical practice. This emphasis provides an excellent illustration of the benefits of the scientist-practitioner model. As such, I believe it will be of particular interest to clinicians and health professionals working with adults with neurological and psychiatric conditions."
Journal of Nervous and Mental Disease
"The editors, Miller and Cummings, have assembled an impressive list of contributors for self-sufficient chapters yet were able to maintain fluidity in flow and consistency in organization....A standard reference for a broad audience. Whereas this book is certainly worthy of such consideration as a standard reference on the frontal lobes, the book's broad accessibility also allows its application as a comprehensive review for scholars in the basic and clinical neurosciences alike. The Human Frontal Lobes belongs on the bookshelf of any serious scholar of the basic neurosciences, behavioral psychology, neurology, neuropsychology, or psychiatry."
Journal of Clinical and Experimental Neuropsychology
"This book is destined to become a classic reference and to have readers eagerly anticipating the next edition. The book not only summarizes what we do know about the frontal lobes but also brings to the forefront many questions still remaining....A book that provides an intellectual pleasure cruise and is deserving of a prominent place on neuroscientists' bookshelves."
The New England Journal of Medicine
"Bruce Miller and Jeffrey Cummings have done a fine job in drawing together the disparate strands of current scientific knowledge that are allowing us to begin to understand this most integrative part of the brain and its particular concern with abstract subject matters....Heartily recommended to anyone interested in this daunting and emerging area of neuroscience."

Product Details

Guilford Publications, Inc.
Publication date:
The Science and Practice of Neuropsychology
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Barnes & Noble
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Meet the Author

Bruce L. Miller, MD, is Professor of Neurology at the University of California at San Francisco (UCSF), where he holds the A.W. & Mary Margaret Clausen Distinguished Chair. He is also the clinical director of the aging and dementia program at UCSF, where he heads the State of California Research and Clinical Center and a new National Alzheimer’s Disease Research Center. For nearly two decades, Dr. Miller has been the scientific director of the John Douglas French Foundation for Alzheimer’s Disease. He has been listed in The Best Doctors in America since 1996. Dr. Miller directs a National Institutes of Health-funded program on frontotemporal dementia (FTD) called “FTD: Genes, Images, and Emotions.” He has published more than 250 articles.
Jeffrey L. Cummings, MD, is Director of the Alzheimer’s Disease Research Center and the Deane F. Johnson Center for Neurotherapeutics at the University of California at Los Angeles (UCLA). He is the Augustus S. Rose Professor of Neurology and Professor of Psychiatry and Biobehavioral Sciences in the David Geffen School of Medicine at UCLA. Dr. Cummings is past president of the American Neuropsychiatric Society and the Behavioral Neurology Society. He is the recipient of several prestigious awards, including the Henderson Lectureship of the American Neurological Society. Dr. Cummings has lectured, pursued research, and published on the topics of neuropsychiatry, behavioral neurology, neurotherapeutics, and drug development. He has contributed to the understanding of the role of the frontal-subcortical circuits in the behavior of normal individuals and of persons with brain disorders, and is the author of the Neuropsychiatric Inventory, a tool used to assess behavioral changes in patients with neurological diseases.

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