Description: This compilation of the proceedings of the International Conference on Cardiac Hypertrophy held in Tokyo in October 1998 provides a comprehensive overview of hypertrophy and heart failure organized into two main sections mechanisms of cardiac hypertrophy and cardiac failure in the hypertrophied heart.
Purpose: The book is intended to bring together reports of state-of-the-art research in cardiac hypertrophy, including cellular and molecular mechanisms in the development of hypertrophy and the transition from the hypertrophy phenotype to the failing heart. Considering the rapid advances in this active field of research, this book succeeds in bringing the reader up-to-date on many different aspects of cardiac hypertrophy research.
Audience: The editors are leaders in the field of cardiac research, and this book should be of interest to students, postdoctoral fellows, faculty, and physicians studying or practicing cardiovascular medicine.
Features: The first section focuses on changes in gene expression that serve as molecular markers of the hypertrophic response and on signal transduction mechanisms that bring about cellular changes characteristic of hypertrophied myocytes. These chapters address cellular remodeling via changes at the molecular level and also consider structural remodeling involving the cytoarchitecture. The data are largely drawn from experiments using animal models of hypertrophy employing state-of-the-art techniques. The second section attempts to establish a link between the hypertrophy phenotype and the manifestation of functional abnormalities culminating in heart failure. This section combines some basic research, again using animal models of heart failure, with clinical observations of human heart failure with respect to possible underlying causes, functional alterations, and therapeutic approaches. However, the book does not include a comprehensive discussion of widely used therapeutic drugs and how they relate to mechanisms discussed in the chapters.