The Hypertrophied Heartby Nobuakira Takeda (Editor)
Whenever the heart is challenged with an increased workload for a prolonged period, it responds by increasing its muscle mass - a phenomenon known as cardiac hypertrophy. Although cardiac hypertrophy is commonly seen under physiological conditions such as development and exercise, a wide variety of pathological situations such as hypertension (pressure overload),
Whenever the heart is challenged with an increased workload for a prolonged period, it responds by increasing its muscle mass - a phenomenon known as cardiac hypertrophy. Although cardiac hypertrophy is commonly seen under physiological conditions such as development and exercise, a wide variety of pathological situations such as hypertension (pressure overload), valvular defects (volume overload), myocardial infarction (muscle loss) and cardiomyopathy (muscle disease) are also known to result in cardiac hypertrophy.
The Hypertrophied Heart compiles state-of-the-art presentations in the area of molecular biology, cellular physiology and signal transduction in cardiac hypertrophy and heart failure to help in the formulation of new concepts and approaches for stimulating research. The book contains two sections: Mechanisms of Cardiac Hypertrophy, and Cardiac Failure in the Hypertrophied Heart. It is hoped that both students and scientists, as well as clinical and experimental cardiologists, will find this book useful in understanding the molecular and cellular events underlying the development of cardiac hypertrophy and the transition from cardiac hypertrophy to heart failure.
Description: This compilation of the proceedings of the International Conference on Cardiac Hypertrophy held in Tokyo in October 1998 provides a comprehensive overview of hypertrophy and heart failure organized into two main sections mechanisms of cardiac hypertrophy and cardiac failure in the hypertrophied heart.
Purpose: The book is intended to bring together reports of state-of-the-art research in cardiac hypertrophy, including cellular and molecular mechanisms in the development of hypertrophy and the transition from the hypertrophy phenotype to the failing heart. Considering the rapid advances in this active field of research, this book succeeds in bringing the reader up-to-date on many different aspects of cardiac hypertrophy research.
Audience: The editors are leaders in the field of cardiac research, and this book should be of interest to students, postdoctoral fellows, faculty, and physicians studying or practicing cardiovascular medicine.
Features: The first section focuses on changes in gene expression that serve as molecular markers of the hypertrophic response and on signal transduction mechanisms that bring about cellular changes characteristic of hypertrophied myocytes. These chapters address cellular remodeling via changes at the molecular level and also consider structural remodeling involving the cytoarchitecture. The data are largely drawn from experiments using animal models of hypertrophy employing state-of-the-art techniques. The second section attempts to establish a link between the hypertrophy phenotype and the manifestation of functional abnormalities culminating in heart failure. This section combines some basic research, again using animal models of heart failure, with clinical observations of human heart failure with respect to possible underlying causes, functional alterations, and therapeutic approaches. However, the book does not include a comprehensive discussion of widely used therapeutic drugs and how they relate to mechanisms discussed in the chapters.
Assessment: This collection of papers presents a survey of the status of cardiac hypertrophy research on an international level. The book places a particular emphasis on basic molecular events involved in the development and progression of the disease state. Understanding these molecular events is important for basic scientists and clinicians alike, to aid in the development of better therapeutic drugs and their most effective use for treatment of cardiac hypertrophy and heart failure.
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