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Sleep, Movement Disorders, and Dopamine will be divided into five parts, each detailing a unique theme: (I) physiology of the dopaminergic system; (II) role of DA in PLMD and RLS; (III) DA hypofunction as a contributor to RBD; (IV) imaging studies in DA deficient states; and finally (V) the downside of DA treatment underlying the fine balance between sleep and wakefulness. Each part will be divided into several chapters further exploring and reviewing recent data as detailed in the table of contents.
Table of Contents:
Preface: Sleep, Movement Disorders, and Dopamine
Alon Avidan MD, MPH
Part I: Role of Dopamine in Sleep and Wakefulness
Chapter 1: Neurobiology of Dopaminergic Modulation of Behavioral States.
Contributor: Alon Y. Avidan MD, MPH, Department of Neurology, UCLA.
Chapter 2: The Two Faces of Eve: Dopamine's Modulation of Wakefulness and Sleep, Emerging Views from an Unlikely Source: Parkinson’s disease.
Contributor/s: D. B. Rye and J. Jankovic, Department of Neurology, Emory University.
Part II: The Role of Dopamine in Restless Leg Syndrome, Periodic Leg Movements and Alternating Leg Muscle Activation
Chapter 3: Restless Legs Syndrome: Revisiting the Dopamine Hypothesis from the Spinal Cord Perspective.
Contributor/s: Paulus W, Schomburg ED. Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Str. 40, 37075 Gottingen, Germany. firstname.lastname@example.org
Chapter 4: Parkinson’s Disease and Restless Legs Syndrome: A Dopaminergic Bridge
Contributor/s: Earley CJ, Hyland K, Allen RP. Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA.
Chapter 5: Treatment of Restless Legs Syndrome with Dopamine Agonists. The Benefits.
Contributor: Karin Stiasny-Kolster, MD, Department of Neurology, Center of Nervous Diseases, Rudolf-Bultmann-Strasse 8, D-35033 Marburg, Germany
Chapter 6: Dopamine D2 Receptor Alteration in Patients with Periodic leg Movements.
Contributor/s: J. Staedt. Department of Psychiatry, Georg August University, Göttingen, Federal Republic of Germany
Chapter 7: The Neurophysiology of the Alternating Leg Muscle Activation (ALMA) during sleep: Why Do Dopamine Agonists Help?
Contributor/s: Cosentino FI, Iero I, Lanuzza B, Tripodi M, Ferri R. Department of Neurology I.C., Sleep Research Centre, Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Via Conte Ruggiero 73, 94018 Troina, Italy.
Part III: Implication of Dopaminergic System in REM Sleep Behavior Disorder
Chapter 8: The Role of Reduced Striatal Dopamine Transporters in Idiopathic Rapid Eye Movement Sleep Behavior Disorder
Contributor/s: Dr Ilonka Eisensehr, R. Linke, S. Noachtar, J. Schwarz, F. J. Gildehaus and K. Tatsch Department of Neurology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany E-mail: email@example.com
Chapter 9: Rapid Eye Movement Sleep Behavior Disorder in Multiple System Atrophy: The Role of Decreased Nigrostriatal Dopaminergic Projections in the Pathophysiology.
Contributor/s: S. Gilman, MD, F. Consens MD, Department of Neurology, University of Michigan, Ann Arbor, USA. firstname.lastname@example.org
Chapter 10: The Use of Domapine Agonists in REM Sleep Behavior Disorder: What Does the Data Show?
Contributor; Schmidt MH, Koshal VB, Schmidt HS. Ohio Sleep Medicine and Neuroscience Institute, Dublin, OH 43017, USA. email@example.com
Part IV: Dopamine and Sleep-Related Movement Disorders. What does imaging Tell Us?
Chapter 11: The Use of Functional Brain Imaging in Investigating the Role of Dopamine in Combined Motor and Sleep Disorders-
Contributor/s: Hilker R, Burghaus L, Razai N, Jacobs AH, Szelies B, Heiss WD. Department of Neurology, Medical University of Cologne, Germany. firstname.lastname@example.org
Chapter 12: SPECT imaging of striatal pre- and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleep.
Contributor/s: Michaud M, Soucy JP, Chabli A, Lavigne G, Montplaisir J. Departement de Psychiatrie Faculte de Medecine Universite de Montreal, Canada.
Chapter 13: Combination of ‘Idiopathic’ REM Sleep Behavior Disorder and Olfactory Dysfunction as Possible Indicator for a-Synucleinopathy Demonstrated by Dopamine Transporter FP-CIT-SPECT.
Contributor/s: Stiasny-Kolster K, Doerr Y, Moller JC, Hoffken H, Behr TM, Oertel WH, Mayer G. Department of Neurology, Center of Nervous Diseases, Philipps University of Marburg, Germany. email@example.com
Chapter 14: Striatal D2 Receptor Binding in Sleep Bruxism: Data from Single-Photon-Emission Computed Tomography.
Contributor/s: Lobbezoo F. Faculte de Medecine Dentaire, Universite de Montreal, Quebec, Canada.
Part V: Dopamine in the Treatment of Sleep-Related Movement Disorders: The Downside.
Chapter 15: Sleep Attacks in Parkinson’s Patients Taking Dopamine Agonists: Is it the Disease or the Drug?
Contributor/s: Comella CL. Department of Neurological Sciences, Rush Medical Center, Chicago, IL 60612, USA. firstname.lastname@example.org
Chapter 16: The Pathophysiology of Dopaminergic-Therapy-Related Augmentation in Restless Legs Syndrome: Less is More.
Contributor/s: Paulus W, Trenkwalder C. Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany. email@example.com
Chapter 17: Pathologic Gambling in Patients with Restless Legs Syndrome Treated with Dopaminergic Agonists.
Contributor/s: Tippmann-Peikert M, Mayo Clinic Sleep Disorders Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. firstname.lastname@example.org