The IRF Family Transcription Factors in Immunity and Oncogenesis

The IRF Family Transcription Factors in Immunity and Oncogenesis

by Tomohiko Tamura, Hideyuki Yanai, David Savitsky, Tadatsugu Taniguchi
     
 
The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was identified in the late 1980s in the context of research into the type I interferon system. Subsequent studies over the past two decades have revealed the versatile and critical functions performed by this transcription factor family. Indeed, many IRF members play central roles in

Overview

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was identified in the late 1980s in the context of research into the type I interferon system. Subsequent studies over the past two decades have revealed the versatile and critical functions performed by this transcription factor family. Indeed, many IRF members play central roles in the cellular differentiation of hematopoietic cells and in the regulation of gene expression in response to pathogen-derived danger signals. In particular, the advances made in understanding the immunobiology of Toll-like and other pattern-recognition receptors have recently generated new momentum for the study of IRFs. Moreover, the role of several IRF family members in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers.

Product Details

ISBN-13:
2940013247406
Publisher:
Annual Reviews
Publication date:
10/25/2011
Series:
Annual Review of Immunology , #26
Sold by:
Barnes & Noble
Format:
NOOK Book
Pages:
49
File size:
7 MB

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