The Laboratory Mouse

The Laboratory Mouse

by Hans Hedrich, Gillian R. Bullock
     
 

This work is part of a series of handbooks, providing research scientists in academia and industry with comprehensive, practical information on the various species of laboratory animal. It will be invaluable to those using mice and for whom the various genetically defined strains and (induced) mutants have become an essential part of their research. Mice are now

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Overview

This work is part of a series of handbooks, providing research scientists in academia and industry with comprehensive, practical information on the various species of laboratory animal. It will be invaluable to those using mice and for whom the various genetically defined strains and (induced) mutants have become an essential part of their research. Mice are now widely recognized as the most important model for human diseases and disorders and are currently the most frequently used of all experimental mammals. They are the model of choice for many reasons:

• They have a very strong genetic similarity to humans
• They are relatively cheap
• Their small size means that they are easy to house and maintain
• They have a short life span and rapid reproductive rate enabling the study of disease processes throughout the life-cycle

Thirty-four chapters provide comprehensive, practical information, including new and authoritative data. Copious illustrations are included throughout, and all artwork has been carefully redrawn for clarity.

The editor of this volume is well known for his expertise in laboratory animal models and genetics. He has been able to call upon the collective expertise of authors from around the globe, representing both academic and industrial research, to produce a balanced, international approach.

It is divided into six sections dealing with:
• History, Development and Genetics of the Mouse as a Laboratory Model
• Anatomy and Developmental Biology
• Pathophysiology (including non-infectious diseases)
• Infectious Agents and Diseases
• Animal Husbandry and Production
• Procedures

This volume will be an essential reference for all researchers and students in biological, veterinary and medical sciences, as well as those in the pharmaceutical industry and commercial toxicology and pathology laboratories.

Key Features
• Edited by Hans Hedrich, Director of the Institute for Laboratory Animal Science at the Hanover Medical School and currently the Editor of the Journal of Experimental Animal Science
• Comprehensive reference source written by international experts
• Well-illustrated with high quality detailed images
• 2-color, user-friendly format combined with colour plate sections

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Product Details

ISBN-13:
9780123364258
Publisher:
Elsevier Science
Publication date:
11/11/2004
Series:
Handbook of Experimental Animals Series
Edition description:
Older Edition
Pages:
656
Product dimensions:
8.12(w) x 10.86(h) x 1.64(d)

Table of Contents

History, Development and Genetics of the Mouse as a Laboratory Model
Origin of the Laboratory Mouse and Related
Historical Foundations
Strain, Stock and Mutants
Mouse Genomics
Generation of Mouse Mutants by Sequence Information Driven and Random Mutagenesis
The Mouse as an Animal Model for Human Diseases
The Mouse in Preclinical Safety Studies
Anatomy and Developmental Biology
Gross Anatomy
Normative Histology of Organs
Imaging
Introduction to Early Mouse Development
Pathophysiology (including non-infectious diseases)
Skin and Adnexes of the Laboratory Mouse
Cardiovascular System
Respiratory Tract
Gastrointestinal System and Metabolism
Inbred Mouse Models for Autoimmune Disease
Hematology of the Mouse
The Social Behaviour of Mice and its Sensory Control
Neuroendocrine - Immune Network in Stress
Circadian Rhythms of the Mouse
Gerontology
Diversity of Spontaneous Neoplasms in Commonly Used Inbred Strains and Stock of Laboratory Mice
Infectious Agents and Diseases
Viral Infections
Animal Husbandry and Production
Housing and Maintenance
Gnotobiology and Breeding Techniques
Assisted Reproduction and Cryopreservation
Health Monitoring
Nutrition of Laboratory Mice
Procedures
Legal Regulations for the Protection of Animals Used for Scientific Experiments
Necropsy Methods
Handling and Restraint
Routes of Administration
Collection of Body Fluids
Anaesthesia, Analgesia and Euthanasia

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