The Laboratory Rat / Edition 3

by Mark A. Suckow, F. Claire Hankenson, Ronald P. Wilson, Patricia L. Foley

Overview

The third edition of The Laboratory Rat features updated information on a variety of topics, including rats as research models for basic and translational research in areas such as genomics, alcoholism, diabetes, metabolic syndrome, obesity, neuroscience, spinal cord injury, traumatic brain injury, regenerative medicine, and infectious disease. New information related to the husbandry and veterinary care of rats is provided including topics related to nutrition, reproduction, anesthesia and surgery, infectious and noninfectious disease, and the care of surgical and other fragile models. It is a premier source of information on the laboratory rat, this book will be of interest to veterinary and medical students, senior graduate students, postdocs and researchers who utilize animals in biomedical research.

Product Details

ISBN-13:	9780128143384
Publisher:	Elsevier Science
Publication date:	11/11/2019
Series:	American College of Laboratory Animal Medicine
Edition description:	3rd ed.
Pages:	1180
Product dimensions:	8.50(w) x 10.88(h) x (d)

About the Author

Mark Suckow received his DVM from the University of Wisconsin in 1987 and subsequently completed a post-doctoral residency in laboratory animal medicine at the University of Michigan in 1990. He spent 8 years as a clinical laboratory animal veterinarian at Purdue University and then 17 years at the University of Notre Dame where he served as Director of the Freimann Life Science Center and later as Associate Vice President for Research Compliance. Prior to coming to the University of Kentucky, he was Professor of Veterinary Population Medicine and Director, Research Animal Resources at the University of Minnesota. With an interest in cancer models, biomaterials models, and vaccines, Dr. Suckow has functioned as an independent and collaborative investigator and has published in refereed journals and has seven issued patents related to vaccine adjuvants and cancer vaccines. He has written or edited over 20 books on topics related to research and laboratory animal medicine. Further, he served as the 2006 President of the American Association for Laboratory Animal Science and the 2011 President of the American Society of Laboratory Animal Practitioners; and currently he serves on the AVMA Council on Research and is a member of the Council on Accreditation of AAALAC, International.

F. Claire Hankenson, DVM, MS, is the Director of MSU Campus Animal Resources and Attending Veterinarian at the Michigan State University. Research interests are refinements in the case and use of animals involved in research studies, particularly rodent clinical medicine, tail biopsy evaluations and humane endpoints.

Ronald P. Wilson, VMA, MS, DACLAM, is the Professor and Chair of Comparative Medicine at Pennsylvania State University. Research interests are related to experimental surgery, pain, analgesia and anesthesia of laboratory animals.

Patricia L. Foley, DVM, DCLAM, is the Director, Division of Comparative Medicine at Georgetown University.

Table of Contents

Background of the laboratory rat
1. Historical Foundations
2. Taxonomy and Stocks and Strains
3. Translational Potential of Rats in Research

Biology and care
4. Functional Anatomy and Physiology
5. Clinical Pathology of the Rat
6. Reproduction and Breeding
7. Assisted Reproductive Technologies and Genetic Modification in Rats
8. Analysis of Behavior in Laboratory Rats
9. Nutrition
10. Housing and Environment

Clinical care and disease
11. Medical Management and Diagnostic Approaches
12. Bacterial, Mycoplasmal, and Mycotic Infections
13. Viral Disease
14. Parasitic Diseases
15. Neoplastic Disease
16. Metabolic, Traumatic, and Miscellaneous Diseases
17. Anesthesia, Analgesia, and Euthanasia
18. Care of Surgical and Other Fragile Models

Rats as research models
19. General Experimental Techniques
20. Integrating Biology with Rat Genomic Tools
21. Gnotobiotics and the Microbiome
22. Toxicology
23. Embryology and Teratology
24. Rat Immunology
25. Cardiovascular Research
26. Rat Models of Alcohol Use Disorder
27. Rat Models of Obesity, Metabolic Syndrome, and Diabetes
28. The Rate in Neuroscience Research
29. Rat Models of Central Nervous System Injury
30. Use of the Rat as a Model in Regenerative Medicine
31. Rat Models of Infectious Disease

What People are Saying About This

From the Publisher

This new edition provides a valuable, comprehensive reference source for anybody working with the laboratory rat

Editorial Reviews

"The new edition continues the tradition of being one of the best references for laboratory animal veterinarians, graduate and post-graduate students, and researchers with interest in the biology, breeding, care, use, and diseases of the laboratory rat. The veterinary pathologist engaged in laboratory animal diagnostics, biomedical research, or toxicologic testing will find chapters on clinical pathology, infections, parasitic disease, neoplastic disease, metabolic and miscellaneous disease, gerontology and age-associated lesions, and models of disease to be quick aids on significant issues without having to resort to more narrow but more in-depth alternative pathology references...the second edition is worthy of its predecessor and remains probably the best all-around reference for the laboratory rat." —Dr. J. T. Yarrington, Vet Path Services, Inc., Cincinnati, Ohio, U.S.A.

"The purpose is to serve as a resource for those using rats in research and those charged with the care of laboratory rats. This book is greatly needed and meets the college's objectives...This book is an important resource for biomedical researchers and those involved in the care of the labroatory rat...the strengths on this [edition] are its broad contemproary coverage, strong referencing and excellent index. This second edition has been eagerly awaited because of major developments in the field since the first edition 26 years ago." —DOODY'S

From the Publisher

Reviewer: Wanda Haschek-Hock, BVSc, PhD (University of Illinois College of Veterinary Medicine)
Description: This second edition on the laboratory rat is a product of the American College of Laboratory Animal Medicine (ACLAM) and comes more than 26 years after the first edition. Old chapters are extensively updated and revised and new chapters cover new areas and those of increasing importance. All chapters have been peer reviewed.
Purpose: The purpose is to serve as a resource for those using rats in research and those charged with the care of laboratory rats. This book is greatly needed and meets the college's objectives.
Audience: The stated targeted audience is veterinarians and investigators engaged in studies of the rat. This book should be useful for laboratory animal veterinarians and residents as well as biomedical scientists and their students.
Features: The book covers standard topics such as stocks and strains, morphology, clinical pathology, diseases and nutrition, as well as timely topics including ethics, transgenics, and assisted reproductive technologies. The book is comprehensive and extensively referenced and the indexing is well done. The illustrations are black and white; printing is often of poor quality. While most topics are extensively covered, the normal biology/physiology of the rat could have been more comprehensively covered and discussed in the context of humans and other species used in research, and better illustrated. The toxicology chapter is disappointing.
Assessment: This book is an important resource for biomedical researchers and those involved in the care of the laboratory rat. While other books are available in this area, the strengths of this one are its broad and contemporary coverage, strong referencing and excellent index. This second edition has been eagerly awaited because of major developments in the field since the first edition 26 years ago.

Doody's Review Service