The Mammary Gland as an Experimental Model

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More About This Textbook


Studies of mammary gland biology are essential in the fight against breast cancer. Moreover, the mammary gland represents an excellent model system for investigation of physiological and pathological processes that occur throughout the body. The branching morphogenesis that occurs during puberty and the alveogenesis processes during pregnancy, for example, recapitulate steps that occur in many tissues during embryogenesis and are also relevant to tumor invasion and metastasis. Similarly, analyses of breast cancer progression and the cell types that contribute to it yield findings applicable not only to breast cancer but widely to other cancers as well.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of mammary gland development, physiology, and tumor formation, emphasizing the value of the organ as a model system. The contributors examine the roles of hormones, growth factors, oncogenes, and the extracellular matrix in normal development and cancer. In addition, they discuss the nature of the mammary gland stem cell population and review the gene expression programs activated and chromatin modifications that occur as the different cell lineages present differentiate. The book also contains chapters covering the many experimental approaches that have been used in this field, including transplantation, genetic engineering, RNA interference and genomics, three dimensional culture models, and live cell imaging. It will thus be of interest to all researchers working in cell, developmental, and cancer biology, as well as those focused specifically on mammary gland biology and breast cancer.

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Product Details

  • ISBN-13: 9780879699062
  • Publisher: Cold Spring Harbor Laboratory Press
  • Publication date: 8/1/2011
  • Pages: 325
  • Product dimensions: 7.20 (w) x 10.30 (h) x 0.90 (d)

Table of Contents

Preface vii

Section I Historical Background

Of Mice and Women: A Short History of Mouse Mammary Cancer Research with an Emphasis on the Paradigms Inspired by the Transplantation Method Daniel Medina 1

A Compendium of the Mouse Mammary Tumor Biologist: From the Initial Observations in the House Mouse to the Development of Genetically Engineered Mice Robert D. Cardiff Nicholas Kenney 13

Choosing a Mouse Model: Experimental Biology in Context-The Utility and Limitations of Mouse Models of Breast Cancer Alexander D. Borowsky 25

Section II Stem Cells

Murine Mammary Epithelial Stem Cells: Discovery, Function, and Current Status Jane E. Visvader Gilbert H. Smith 41

Stem Cells in the Human Breast Ole William Petersen Kornelia Polyak 55

Section III Signaling

Hormone Action in the Mammary Gland Cathrin Brisken Bert O'Malley 71

Mammary Gland Growth Factors: Roles in Normal Development and in Cancer Nancy E. Hynes Christine J. Watson 87

Cell-Matrix Interactions in Mammary Gland Development and Breast Cancer John Muschler Charles H. Streuli 105

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression Pepper Schedin Patricia J. Keely 123

Oncogenes and Tumor Suppressor Genes Eva Y.H.P. Lee William J. Muller 145

Section IV Mammary Gland Developmental Biology and Cancer

The Role of the Microenvironment in Mammary Gland Development and Cancer Kornelia Polyak Raghu Kalluri 163

Molecular Mechanisms Guiding Embryonic Mammary Gland Development Pamela Cowin John Wysolmerski 177

TGF-β Biology in Mammary Development and Breast Cancer Harold Moses Mary Helen Barcellos-Hoff 191

Mammary Gland Reprogramming: Metalloproteinases Couple Form with Function Rama Khokha Zena Werb 205

Leukocytes in Mammary Development and Cancer Lisa M. Coussens Jeffrey W. Pollard 225

Systems Biology and Genomics of Breast Cancer Charles M. Perou Anne-Lise Børresen-Dale 247

Using Functional Genetics to Understand Breast Cancer Biology Alan Ashworth Rene Bernards 265

Chromatin Remodeling in Mammary Gland Differentiation and Breast Tumorigenesis Tim H.-M. Huang Manel Esteller 277

In Vivo Imaging in Cancer John Condeelis Ralph Weissleder 293

Afterword 315

Index 319

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