The Mobile Receptor Hypothesis: The Role of Membrane Receptor Lateral Movement in Signal Transduction

The Mobile Receptor Hypothesis: The Role of Membrane Receptor Lateral Movement in Signal Transduction

by David A. Jans
     
 

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The Fluid Mosaic model of biological membranes, formulated over 20 years ago, implies that receptors float freely within the plane of the membrane. This book is a critical exposition of the theory behind and evidence for the mobile receptor hypothesis. It treats the direct evidence for the mobile receptor hypothesis with particular respect to tyrosine kinase receptors

Overview

The Fluid Mosaic model of biological membranes, formulated over 20 years ago, implies that receptors float freely within the plane of the membrane. This book is a critical exposition of the theory behind and evidence for the mobile receptor hypothesis. It treats the direct evidence for the mobile receptor hypothesis with particular respect to tyrosine kinase receptors such as those for insulin and epidermal growth factor, and the GTP-binding protein activating V1- and V2-type receptors for vasopressin.

Editorial Reviews

Booknews
Elucidates some critical mechanisms of biological cell phones, signal transmission at the level of the membrane, the primary transducer of extracellular signals represented by hormones, growth factor, and other chemicals. Elaborates the theory and experimental evidence that receptors can diffuse freely within the plane of the membrane and that the diffusion is what allows interactions between protein signaling components. The theory has been accepted for two decades, but little studied. The goal is to encourage researchers to think of the membrane as two-dimensional rather than one, as a lattice of sites for interactions rather than an inert barrier to keep insides of the cell in and everything else out. Annotation c. by Book News, Inc., Portland, Or.

Product Details

ISBN-13:
9781475706826
Publisher:
Springer US
Publication date:
04/30/2013
Series:
Molecular Biology Intelligence Unit Series
Edition description:
Softcover reprint of the original 1st ed. 1997
Pages:
224
Product dimensions:
5.98(w) x 9.02(h) x 0.02(d)

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