The Molecular Basis of Cancer: Expert Consult - Online and Print

Overview

The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. ...

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The Molecular Basis of Cancer: Expert Consult - Online

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Overview

The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application.


• Effectively determine
the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer.
• Visually grasp and retain difficult concepts easily
thanks to a user-friendly format with abundant full-color figures.
• Find critical information quickly
with chapters following a logical sequence that moves from pathogenesis to therapy.


• Stay current with the latest discoveries in molecular and genomic research.
Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology.
• Access the entire text and illustrations online
, fully searchable, at Expert Consult.

The book contains black-and-white illustrations.

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Editorial Reviews

From the Publisher
“Each chapter is written by a well-known authority in the respective field...An outstanding achievement.” – Journal of the National Cancer Institute, review of the 1st edition

“Easy to read but contains a wealth of information...achieves its goal of being both educational and exhaustive.” – The Cancer Bulletin, review of the 1st edition

Doody's Review Service
Reviewer: Karen L Reckamp, MD, MS (City of Hope)
Description: Cancer and its molecular basis encompasses a broad scope of biology that includes genetics and epigenetics, cell cycle regulation, tumor microenvironment and angiogenesis, and immunology partnered with clinical applications and complex bioinformatics to improve treatments for patients. The rapid pace of discovery in the molecular biology of cancer requires continued evaluation of the data to understand and integrate the advances. The objective of this book is to provide information regarding the mechanisms that result in carcinogenesis and therapeutic interventions for cancer.
Purpose: The aims are to explain the genetic and molecular mechanisms of cancer development, growth, and metastasis in a sequential manner, then describe the progress made in analytic technologies and bioinformatics that allow for precision medicine in cancer diagnostics and treatment. Finally, the book presents the underlying molecular biology and advances to demonstrate current cancer care and implications for future approaches.
Audience: The intended audience includes clinicians and healthcare professionals who care for cancer patients, as well as clinical and laboratory-based biomedical researchers and advanced students and trainees.
Features: With this fourth edition, the book has been expanded and the content adapted to reflect the evolving field of molecular biology in cancer to maintain its relevance in cancer care. This book brings together an exceptional group of authors with the expertise to educate its audience on the molecular underpinnings of cancer and its applications. Chapters can be read individually or in the context of the full work that moves through mechanisms and biology to the analysis of complex data and understanding of therapy. The figures and tables enhance comprehension.
Assessment: This is a well-organized and well-written book that improves readers' understanding of the diverse mechanisms involved in cancer risk, growth, and treatments. The book provides a unique experience, uniting basic science with clinical applications to provide an integrated appreciation of the diverse molecular biology of cancer. It should be in the library of anyone interested in cancer research and treatment.
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Product Details

  • ISBN-13: 9781455740666
  • Publisher: Elsevier Health Sciences
  • Publication date: 3/5/2014
  • Edition description: New Edition
  • Edition number: 4
  • Pages: 888
  • Sales rank: 650,114
  • Product dimensions: 8.70 (w) x 11.10 (h) x 1.30 (d)

Table of Contents

The Molecular Basis of Cancer, 4e

Mendelsohn, Howley, Israel, Gray, Thompson

Part I: Carcinogenesis and Cancer Genetics

1. Cancer, A Genetic Disorder

2. Oncogenes and Signal Transduction

3. Tumor Suppressor Genes

4. Genomic Instability and DNA Repair

5. Epigenetics and Cancer

6. Infectious Agents and Cancer

7. Environmental Carcinogenesis

8. Animal Models: Flies, Fish and Yeast

9. Genetic Mouse Models of Cancer

Part II: Cancer Biology

10. Cancer Stem Cells

11. Regulation of the Cell Cycle

12. Cell Growth

13. Cancer Cell Metabolism

14. Apoptosis, Autophagy and Necrosis

15. Cell Growth Arrest and Senescence

16. Stromal-Cancer Interactions in the Microenvironment

17. Hypoxia and Angiogenesis

18. Invasion and Metastasis

19. Inflammation and Cancer

20. Molecular Pathways and Systems Biology

Part III: Molecular Pathology and Diagnostics

21. Biomarkers Assessing Risk of Cancer

22. Biomarkers for Detecting Cancer: Molecular Screening

23. Biomarkers for Predicting Response to Specific Therapy

24. The Technology of Analyzing Nucleic Acids

25. Imaging Cancer

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