The Neurobiology of Disease: Contributions from Neuroscience to Clinical Neurology

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Demonstrating the value of interactions between neurology and the basic sciences that underpin it, this volume considers a range of topics from the points of view of both neurobiologist and clinician and reveals how advances in our understanding have been and continue to be made. The selected topics cover a wide range of levels of organization in the nervous system. For each one, distinguished researchers from around the world have made contributions, including general reviews of normal and pathological mechanisms as well as detailed accounts of the basic processes involved.

The book contains black-and-white illustrations.

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Editorial Reviews

From the Publisher
"...a valuable read as it projects an immediate overview and understanding of key membrane and molecular events involved in axonal conductions and mechanisms of neural control and neural viability in health and disease." Roger N. Rosenberg, Archives of Neurology

"...this is a well-written, adequately illustrated, and generally interesting textbook that will be found a useful resource for neuroscientists of all different specialties." Martin Bettag, Neurosurgery Review

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Product Details

  • ISBN-13: 9780521342384
  • Publisher: Cambridge University Press
  • Publication date: 6/30/2011
  • Pages: 464
  • Product dimensions: 6.00 (w) x 9.00 (h) x 1.20 (d)

Table of Contents

List of contributors
1 Ion channels in normal and pathophysiological mammalian peripheral myelinated nerve 3
2 Molecular anatomy of the node of Ranvier: newer concepts 13
3 Delayed rectifier type potassium currents in rabbit and rat axons and rabbit Schwann cells 29
4 Axonal signals for potassium channel expression in Schwann cells 37
5 Ion channels in human axons 47
6 An in vitro model of diabetic neuropathy: electrophysiological studies 61
7 Autoimmunity at the neuromuscular junction 69
8 Immunopathology and pathophysiology of experimental autoimmune encephalomyelitis 75
9 Pathophysiology of human demyelinating neuropathies 86
10 Conduction properties of central demyelinated axons: the generation of symptoms in demyelinating disease 95
11 Mechanisms of relapse and remission in multiple sclerosis 118
12 Glial transplantation in the treatment of myelin loss or deficiency 124
13 Human nociceptors in health and disease 151
14 Sensory consequences of inflammation 162
15 Non-voluntary muscle activity and myofascial pain syndromes 169
16 Is there a mechanism for the spinal cord to remember pain? 177
17 The neurophysiological basis of pain relief by acupuncture 189
18 Synaptic transduction in neocortical neurones 201
19 Cortical circuits, synchronization and seizures 210
20 Physiologically induced changes of brain temperature and their effect on extracellular field potentials 221
21 Fusimotor control of the respiratory muscles 231
22 Cerebral accompaniments and functional significance of the long-latency stretch reflexes in human forearm muscles 241
23 The cerebellum and proprioceptive control of movement 247
24 Roles of the lateral nodulus and uvula of the cerebellum in cardiovascular control 257
25 Central actions of curare and gallamine: implications for reticular reflex myoclonus? 266
26 Pathophysiology of upper motoneurone disorders 276
27 Modulation of hypoglossal motoneurones by thyrotropin-releasing hormone and serotonin 283
28 Serotonin and central respiratory disorders in the newborn 292
29 Are medullary respiratory neurones multipurpose neurones? 299
30 Reflex control of expiratory motor output in dogs 309
31 Abnormal thoraco-abdominal movements in patients with chronic lung disease 318
32 Respiratory rhythms and apnoeas in the newborn 327
33 Cardiorespiratory interactions during apnoea 337
34 Impairment of respiratory control in neurological disease 348
35 The respiratory muscles in neurological disease 358
36 Axonal growth and plasticity in the adult nervous system 373
37 Target dependence of motoneurones 379
38 Rescue of neurones cross-regenerated into foreign targets 395
39 Development and repair of neonatal mammalian spinal cord in culture 405
40 Selective neuronal vulnerability in motor neurone diseases with reference to sparing of Onuf's nucleus 411
41 Excitotoxicity in motor neurone diseases 427
Index 436
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