The Organic Chemistry of Drug Design and Drug Action / Edition 1

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Overview

This book provides a new approach to the teaching and understanding of medicinal chemistry. It is a survey of basic principles of drug design and drug action in which the concepts are presented from a physical organic chemistry perspective so that the design, development, and mechanisms of action and metabolism of drugs can be rationally understood. The reader is then able to apply these principles to any specific classes of drugs of interest and to understand how these drugs might act at a molecular level.

KEY FEATURES
*Provides an organic and synthetic chemist's perspective of how drugs are designed and how they function
*Teaches organic chemists and biochemists the fundamentals of drug design and drug action using drugs as examples
*No prior knowledge of biochemistry, pharmacology, or physiology is assumed
*Extensive use of references to the primary and secondary literature for more in depth reading about all concepts
*Extensive use of structures, schemes, and figures to illustrate points
*Problem sets and answers are included for each topic
*Informal but clear writing style so practicing chemists and undergraduates can easily understand the concepts presented

Richard B. Silverman is professor has published over 200 articles in the areas of synthesis, bioorganic chemistry, and medicinal chemistry, has been awarded 21 patents, and has invented a drug that is under consideration for commercialization.
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Editorial Reviews

Booknews
A textbook for a semester course in medicinal chemistry for senior or first-year graduate students of chemistry or biochemistry. Approaches the subject, not from the usual perspective of classes of drugs, but by the organic chemical mechanisms and effect desired when designing new drugs. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780126437300
  • Publisher: Elsevier Science & Technology Books
  • Publication date: 1/28/1992
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 421
  • Product dimensions: 6.59 (w) x 9.51 (h) x 0.99 (d)

Read an Excerpt

The long-awaited revision of this classic bestseller!
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Table of Contents

PREFACE

CHAPTER 1 -- Introduction

CHAPTER 2 -- Drug Discovery, Design, and Development

CHAPTER 3 -- Receptors

CHAPTER 4 -- Enzymes (Catalytic Receptors)

CHAPTER 5 -- Enzyme Inhibition and Inactivation

CHAPTER 6 -- DNA-Interactive Agents

CHAPTER 7 -- Drug Metabolism

CHAPTER 8 -- Prodrugs and Drug Delivery Systems

INDEX
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