The Pharmacological Basis of Therapeutics

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The landmark text in medical pharmacology is now in full color

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"This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance....This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline ...

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Overview

The landmark text in medical pharmacology is now in full color

Includes DVD with image bank

A Doody's Core Title ESSENTIAL PURCHASE for 2011!

4 STAR DOODY'S REVIEW!

"This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance....This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline of pharmacology with therapeutics. Moreover, readers will find this edition to be substantially improved from past editions in both content and physical appearance."—Doody's Review Service

The most universally respected and read medical text in all of pharmacology, Goodman & Gilman’s The Pharmacological Basis of Therapeutics represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease.

Enriched by a new full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the twelfth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents. The companion DVD includes all the images and tables in the text along with narrated animations.

Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12e is divided into nine sections, covering:

  • General Principles
  • Neuropharmacology
  • Modulation of Cardiovascular Function
  • Inflammation, Immunomodulation, and Hematopoiesis
  • Endocrine Pharmacology
  • Gastrointestinal Pharmacology
  • Chemotherapy of Infectious Disease
  • Chemotherapy of Neoplastic Diseases
  • Special Systems Pharmacology

More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.

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Editorial Reviews

From The Critics
Reviewer: Thomas L. Pazdernik, PhD(University of Kansas Medical Center)
Description: This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance.
Purpose: The guiding principles established in the first edition published in 1941 were to relate current medical scientific information to the actions of drugs with a focus on the application of pharmacodynamic principles to therapeutics. These basic principles have been the basis of all further editions of this multiauthored book, with the addition of new chapter authors and the implementation of advances in publishing formats, including new full-color figures and narrated animations in this current version. This edition retains the best of the original while incorporating advances in science and publishing to yield a very useful and informative book bridging pharmacology and therapeutics. The editors have done an outstanding job with this edition.
Audience: With its balance of basic science and clinical application, this book has served as the most authoritative resource guiding thousands of teachers, students, and practitioners to a clear understanding of how to use drugs to advance medical science with the goal of preventing, diagnosing, and treating diseases. This edition continues to provide valuable guidance to anyone dealing with any facet of pharmacology or therapeutics.
Features: The organization of this book is similar to previous editions and comparable to those found in most pharmacology textbooks. However, this edition is enriched by the contributions of 50 new scientific experts who have joined with many past chapter authors to bring readers the most current information on drugs used in therapy. The focus on basic principles continues with new chapters on drug invention, molecular mechanisms of drug action, drug toxicity and poisoning, principles of antimicrobial therapy, and pharmacotherapy of obstetrical and gynecological disorders. All figures are now in full color and the editors have standardized the format from chapter to chapter so that readers will find details of interest under the same bold heading in each chapter. Extensive use of well-designed figures (over 440), tables, and bulleted points will help students who wish to focus on high-yield information for local and national examinations. An online version is available at McGraw-Hill's websites, AccessMedicine.com and AccessPharmacy.com and it contains updates, reviews of newly approved drugs, animations of drug action, and hyperlinks to relevant information in prior editions, plus all of the other enrichments offered via these sites including hyperlinks of drugs to drug monographs (I use this almost on a daily basis). Moreover, a CD with an image bank accompanies the book and makes all tables and figures available for use in presentations.
Assessment: This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline of pharmacology with therapeutics. Moreover, readers will find this edition to be substantially improved from past editions in both content and physical appearance.
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Product Details

  • ISBN-13: 9780023447815
  • Publisher: Macmillan Publishing Company, Incorporated
  • Publication date: 1/1/1975
  • Edition number: 5
  • Pages: 1704

Meet the Author

Editor:

Laurence L. Brunton, PhD

Professor of Pharmacology and Medicine

University of California San Diego

School of Medicine

La Jolla, CA

Associate Editors:

Bruce A. Chabner, MD

Clinical Director

MDF Cancer Center

Professor of Medicine

Harvard Medical School

Boston, MA

Bjorn Christian Knollmann, MD, PhD

Associate Professor of Medicine and Pharmacology

Oates Institute for Experimental Therapeutics

Vanderbilt University School of Medicine

Division of Clinical Pharmacology

Nashville, TN

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Table of Contents

Contributors Consultants to the Editors Preface Preface to the First Edition
SECTION I: GENERAL PRINCIPLES
1. Drug Invention and the Pharmaceutical Industry, Suzanne M. Rivera and Alfred Goodman Gilman
2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination, Iain L. O. Buxton and Leslie Z. Benet
3. Pharmacodynamics: Molecular Mechanisms of Drug Action, Donald K. Blumenthal and James C. Garrison
4. Drug Toxicity and Poisoning, Kevin C. Osterhoudt and Trevor M. Penning
5. Membrane Transporters and Drug Response, Kathleen M. Giacomini and Yuichi Sugiyama
6. Drug Metabolism, Frank J. Gonzalez, Michael Coughtrie, and Robert H. Tukey
7. Pharmacogenetics, Mary V. Relling and Kathleen M. Giacomini
SECTION II: NEUROPHARMACOLOGY
8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems, Thomas C. Westfall and David P. Westfall
9. Muscarinic Receptor Agonists, Joan Heller Brown and Nora Laiken
10. Anticholinesterase Agents, Palmer Taylor
11. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia, Ryan E. Hibbs and Alexander C. Zambon
12. Adrenergic Agonists and Antagonists, Thomas C. Westfall and David P. Westfall
13. 5-Hydroxytryptamine (Serotonin) and Dopamine, Elaine Sanders-Bush and Lisa Hazelwood
14. Neurotransmission and the Central Nervous System, Perry B. Molinoff
15. Drug Therapy of Depression and Anxiety Disorders, James M. O'Donnell and Richard C. Shelton
16. Pharmacotherapy of Psychosis and Mania, Jonathan M. Meyer
17. Hypnotics and Sedatives, S. John Mihic and r. Adron Harris
18. Opioids, Analgesia, and Pain Management, Tony L. Yaksh and Mark S. Wallace
19. General Anesthetics and Therapeutic Gases, Piyush M. Patel, Hemal H. Patel, and David M. Roth
20. Local Anesthetics, William A. Catteral nad Kenneteh Mackie
21. Pharmacotherapy of the Epilepsies, James O. McNamara
22. Treatment of Central Nervous System Degenerative Disorders, David G. Standaert and Erik D. Roberson
23. Ethanol and Methanol, Marc A. Schuckit
24. Drug Addition, Charles P. O'Brien
SECTION III: MODULATION OF CARDIOVASCULAR FUNCTION
25. Regulation of Renal Function and Vascular Volume, Robert F. Reilly and Edwin K. Jackson
26. Renin and Angiotensin, Randa Hilal-Dandan
27. Treatment of Myocardial Ischemia and Hypertension, Thomas Michel and Brian B. Hoffman
28. Pharmacotherapy of Congestive Heart Failure, Bradley A. Maron and Thomas P. Rocco
29. Anti-Arrhythmic Drugs, Kevin J. Sampson and Robert S. Kass
30. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs, Jeffrey I. Weitz
31. Drug Therapy for Hypercholesterolemia and Dyslipiedmia, Thomas P. Bersot
SECTION IV: INFLAMMATION, IMMUNOMODULATION, AND HEMATOPOIESIS
32. Histamine, Bradykinin, and Their Antagonists, Randal A. Skidgel, Allen P. Kaplan, and Ervin G. Erdös
33. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor, Emer M. Smyth, Tilo Grosser, and Garret A. Fitzgerald
34. Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacology of Gout, Tilo Grosser, Emer Smyth, and Garret A. FitzGerald
35. Immunosupressants, Tolerogens, and Immunostimulants, Alan M. Krensky, William M. Bennett, and Flavio Vincenti
36. Pulmonary Pharmacology, Peter J. Barnes
37. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins, Kenneth Kaushansky and Thomas J. Kipps
SECTION V: HORMONES AND HORMONE ANTAGONISTS
38. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis, Keith L. Parker and Bernard P. Schimmer
39. Thyroid and Anti-Thyroid Drugs, Gregory A. Brent and Ronald J. Koenig
40. Estrogens and Progestins, Ellis R. Levin and Stephen R. Hammes
41. Androgens, Peter J. Snyder
42. ACTH, Adrenal Steroids, and Pharmacology of the Adrenal Cortex, Bernard P. Schimmer and John W. Funder
43. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia, Alvin C. Powers and David D'Alessio
44. Agents Affecting Mineral Ion Homeostatis and Bone Turnover, Peter A. Friedman
SECTION VI: DRUGS AFFECTING GASTROINTESTINAL FUNCTION
45. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease, John L. Wallace and Keith A. Sharkey
46. Treatment of Disorders of Bowel Motility and Water Flux: Anti-Emetics; Agents Used in Biliary and Pancreative Disease, Keith A. Sharkey and John L. Wallace
47. Pharmacotherapy of Inflammatory Bowel Disease, John L. Wallace and Keith A. Sharkey
SECTION VII: CHEMOTHERAPY OF MICROBIAL DISEASES
48. General Principles of Antimicrobial Therapy, Tawanda Gumbo
49. Chemotherapy of Malaria, Joseph M. Vinetz, Jerome Clain, Viengngeun Bounkeua, Richard T. Eastman, and David Fidock
50. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections, Margaret A. Phillips, Samuel L. Stanley, Jr.
51. Chemotherapy of Helminth Infections, James McCarthy, Alex Loukas, and Peter J. Hotez
52. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections, William A. Petri, Jr.
53. Penicillins, Cephalosporins, and Other ß-Lactam Antibiotics, William A. Petri, Jr.
54. Aminoglycosides, Conan MacDougall and Henry F. Chambers
55. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents, Conan MacDougall and Henry F. Chambers
56. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy, Tawanda Gumbo
57. Antifungal Agents, John E. Bennett
58. Antiviral Agents (Nonretroviral), Edward P. Acosta and Charles Flexner
59. Antiretroviral Agents and Treatment of HIV Infection, Charles Flexner
SECTION VIII: CHEMOTHERAPY OF NEOPLASTIC DISEASES
60. General Principles of Cancer Chemotherapy, Bruce A. Chabner
61. Cytotoxic Agents, Bruce A. Chabner, Joseph Bertino, James Cleary, Taylor Ortiz, Andrew Lane, Jeffrey G. Supko, and David Ryan
62. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines, Bruce A. Chabner, Jeffrey Barnes, Joel Neal, Erin Olson, Hamza Mujagic, Lecia Sequist, Wynham Wilson, Dan L. Longo, Constantine Mitsiades, and Paul Richardson
63. Natural Products in Cancer Chemotherapy: Hormones and Related Agents, Beverly Moy, Paul Goss, Richard J. Lee, and Matthew Smith
SECTION IX: OPHTHALMOLOGY
64. Ocular Pharmacology, Jeffrey D. Henderer and Christopher J. Rapuano
65. Dermatological Pharmacology, Craig Burkhart, Dean Morrell, and Lowell Goldsmith
66. Contraception and Pharmacotherapy of Obstetrical and Gynecological Disorders, Bernard P. Schimmer and Keith L. Parker
67. Environmental Toxicology: Carcinogens and Heavy Metals, Michael C. Byrns and Trevor M. Penning
APPENDICES
I. Principles of Prescription Order Writing and Patient Compliance, Iain L.O. Buxton
II. Design and Optimization of Dosage Regimens: Pharmacokinetic Data, Kenneth E. Thummel, Danny D. Shen, and Nina Isoherranen
Index

Editor:

Laurence L. Brunton, PhD

Professor of Pharmacology and Medicine

University of California San Diego

School of Medicine

La Jolla, CA

Associate Editors:

Bruce A. Chabner, MD

Clinical Director

MDF Cancer Center

Professor of Medicine

Harvard Medical School

Boston, MA

Bjorn Christian Knollmann, MD, PhD

Associate Professor of Medicine and Pharmacology

Oates Institute for Experimental Therapeutics

Vanderbilt University School of Medicine

Division of Clinical Pharmacology

Nashville, TN

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