The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Levelby Jessica Wapner
Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to
Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same.Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tributewith extensive original reporting, including more than thirty-five interviewsto the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it.The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.
- Experiment, The
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What People are saying about this
—Siddhartha Mukherjee, Pulitzer Prize-winning author of The Emperor of all Maladies
—Siddhartha Mukherjee, Pulitzer Prize–winning author of The Emperor of All Maladies
“Jessica Wapner shows us in The Philadelphia Chromosome how the past and the future combine to dramatically change the course of a disease. This beautifully written book is a blueprint for broader healthcare change. A pivotal book.”
—David B. Agus, MD, Professor of Medicine and Engineering, University of Southern California, and author of The End of Illness
Meet the Author
Jessica Wapner is a freelance writer focused mainly on healthcare and medicine. Her work is published in The New York Times, Scientific American, Slate, Science, Nature Medicine, Ode, and Psychology Today. Her writing on cancer research and treatment also appears in the science magazines Oncology Business Review, Cure, and CR. Her blog, Work in Progress, is part of the PLoS Blog Network and focuses on the ethics and economics of drug development. She was the founding managing editor of two review journals, Clinical Advances in Hematology & Oncology and Gastroenterology & Hepatology, and also served as editor for Oncology Spectrum. She lives in Beacon, New York, with her husband and two young children.
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Good story of scientific discovery in medicine.