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The Renin-Angiotensin System: Comparative Aspects

Overview

The renin-angiotensin system and the mechanisms regulating this system developed during the adaptive evolution of vertebrates, along with many other systems involved in the integrated survival of the organism.
In this book, advances in research on the renin-angiotensin system are described with emphasis on the comparative aspects. Only this comparative approach provides the understanding of the structure and function of adaptive systems and facilitates the development of general...

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Overview

The renin-angiotensin system and the mechanisms regulating this system developed during the adaptive evolution of vertebrates, along with many other systems involved in the integrated survival of the organism.
In this book, advances in research on the renin-angiotensin system are described with emphasis on the comparative aspects. Only this comparative approach provides the understanding of the structure and function of adaptive systems and facilitates the development of general principles governing these systems among the various animal groups.

Comparative morphology of the juxtaglomerular apparatus, regulation of renin release, biological actions, etc.

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Product Details

  • ISBN-13: 9783642647253
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 12/31/2013
  • Series: Zoophysiology Series , #35
  • Edition description: Softcover reprint of the original 1st ed. 1996
  • Pages: 245
  • Product dimensions: 6.14 (w) x 9.21 (h) x 0.55 (d)

Table of Contents

1 Introduction.- 1.1 Evolutionary Aspects of the Renin-Angiotensin System (RAS).- 1.2 Historical Background of RAS.- 1.3 Survey of Books and Reviews.- 2 Comparative Morphology of the Juxtaglomerular Apparatus (JGA).- 2.1 Mammals.- 2.1.1 Components of JGA.- 2.1.2 Juxtaglomerular (JG) Cells in Afferent Arterioles.- 2.1.2.1 Staining of Granules in JG Cells.- 2.1.2.2 Cellular Localization of Renin.- 2.1.2.3 Electron Microscopy.- 2.1.3 Extraglomerular Mesangium (EGM) and Macula Densa (MD).- 2.1.4 Efferent Arterioles.- 2.1.5 Peripolar Cells.- 2.2 Birds.- 2.3 Reptiles.- 2.4 Amphibians.- 2.5 Fishes.- 2.5.1 JG Cells in Teleosts with Glomerular Kidney.- 2.5.2 JG Cells in Teleosts with Aglomerular Kidney.- 2.5.3 Renin Activity, MD, EGM and Peripolar Cells in Glomerular and Aglomerular Fishes.- 2.5.4 Sarcopterygians and Primitive Bony Fishes.- 2.5.5 Holocephalans.- 2.5.6 Elasmobranchs.- 2.5.7 Cyclostomes.- 2.5.8 Summary.- 3 Innervation in the JGA.- 3.1 Light Microscopy.- 3.2 Electron Microscopy.- 3.3 Summary.- 4 Tissue Distribution of the RAS.- 4.1 Renin.- 4.2 Angiotensinogen.- 4.3 Converting Enzyme.- 4.4 Angiotensins.- 4.5 Nonmammalian Vertebrates.- 5 Regulation of Renin Release.- 5.1 Factors Affecting Renin Release.- 5.1.1 Baroreceptor.- 5.1.2 Macula Densa.- 5.1.3 Renal Nerve.- 5.1.4 Humoral Factors.- 5.1.4.1 Ions.- 5.1.4.2 Amines.- 5.1.4.3 Peptides.- 5.1.4.4 Steroids.- 5.1.4.5 Prostaglandins.- 5.1.4.6 Adenosines.- 5.2 Subcellular Mechanisms.- 5.3 Nonmammalian Vertebrates.- 5.3.1 Birds.- 5.3.2 Reptiles.- 5.3.3 Amphibians.- 5.3.4 Fishes.- 6 Biochemistry of the RAS.- 6.1 Renin.- 6.2 Angiotensinogen.- 6.3 Angiotensin I.- 6.4. Converting Enzyme.- 6.5 Angiotensinases.- 6.6 Nonmammalian Vertebrates.- 6.6.1 Birds.- 6.6.2 Reptiles.- 6.6.3 Amphibians.- 6.6.4 Fishes.- 7 Angiotensin Receptors.- 7.1 Structure of ANG II Receptors.- 7.2 ANG II Receptors in Target Tissues.- 7.2.1 Peripheral Tissues.- 7.2.1.1 Muscular Tissues.- 7.2.1.2 Nonmuscular Tissues.- 7.2.2 Central Nervous System.- 7.3 Signal Transduction of ANG II Receptors.- 7.4 Nonmammalian Vertebrates.- 8 Biological Actions of ANG II.- 8.1 Renal Dipsogen — Historical Background.- 8.2 Exogenous ANG II and Drinking.- 8.2.1 Mammals.- 8.2.2 Birds.- 8.2.3 Reptiles.- 8.2.4 Amphibians.- 8.2.5 Fishes.- 8.2.6 Summary.- 8.3 Endogenous ANG II and Drinking.- 8.3.1 Plasma ANG II and Drinking.- 8.3.2 Drinking and ANG II Antagonists, Renin Inhibitors and Converting Enzyme Inhibitors.- 8.3.3 Brain ANG and Drinking.- 8.3.4 Summary.- 8.4 Sites of Action of ANG II in Drinking.- 8.4.1 Subfornical Organ (SFO).- 8.4.2 Preoptic Area.- 8.4.3 Organum Vasculosum of Lamina Terminalis (OVLT).- 8.4.4 Median Preoptic Nucleus (MnPO).- 8.4.5 Neural Connections Between SFO, OVLT and MnPO.- 8.4.6 Other Possible Receptive Sites for ANG II.- 8.4.7 Nonmammalian Vertebrates.- 8.4.8 Summary.- 8.5 ANG II and Sodium Appetite.- 8.5.1 Mammals.- 8.5.2 Birds.- 8.5.3 Summary.- 8.6 Release of Hormones by ANG II.- 8.6.1 Neurohypophysial Hormones.- 8.6.2 ACTH and CRH.- 8.6.3 Prolactin (PRL).- 8.6.4 GH and TSH.- 8.6.5 LH and LHRH.- 8.6.6 Corticoids.- 8.7 Other Actions of ANG II.- 9 General Conclusions.- 9.1 Comparative Anatomy of the RAS.- 9.1.1 Invertebrates.- 9.1.2 Components of JGA.- 9.1.3 Tissue RAS.- 9.2 Renin Release.- 9.3 Comparative Biochemistry of the RAS.- 9.3.1 Components of the RAS.- 9.3.2 Receptors and Cellular Mechanisms.- 9.4 Biological Actions.- 9.4.1 Body Fluid Regulation.- 9.4.2 Ecological Aspects of ANG II-Induced Drinking.- 9.4.3 ANG II and Reaction to Emergency.- References.

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