The Search for Anti-Inflammatory Drugs: Case Histories from Concept to Clinicby Vincent J. Merluzzi
This book will be a valuable asset for a medical or university library, as well as for researchers and clinicians. It will make an enticing reading for non-specialists interested in the history behind modern pharmacology, and can be used as a textbook in graduate courses.
Description: This book is a collection of nine chapters describing successful drug discovery efforts.
Purpose: As Otterness, at the end of the first chapter, observes: "...Drugs are now targeted extremely specifically against a single mechanism. This greatly reduces the chances of undesired effects. Today the challenge for drug discovery is rarely whether we can develop an inhibitor of a specific mechanism....Can we choose a target mechanism well enough that an inhibitor will have a good probability of being therapeutically effective?..."
Audience: This book may be instructive to those beginning careers in pharmaceutical science and help those already in the trenches recover a view of the larger picture. Based on the histories presented here, all drug candidates meet determined resistance somewhere along their path to approval, and each requires one or more champions to shepherd them through.
Features: An introductory historical perspective nicely sets the stage for the chapters that follow. Each chapter serves as an example of one of three approaches to drug discovery. Chapters 2 and 3 demonstrate the utility of screening rnicrobiological extracts for drug candidates or lead molecules. Chapters 4 and 10 describe medicinal chemistry approaches, beginning with known drugs, that seek to improve efficacy, bioavailability, and/or reduce side effects. The remaining chapters describe mechanistic approaches, targeting a receptor or enzyme with lead compounds based on substrates, or discovered from compound library screens.
Assessment: The individual contributions are well written and interesting, providing a sense of the team effort required for success. However, the chapter on cyclosporine is too long and somewhat self-aggrandizing. Readers not intimately involved with the industry may get bogged down in details of the medicinal chemistry and clinical trials in some chapters, and expanded discussion of the decision-making processes would have been welcomed. Still, a careful reader of this book will come away with the message that good science is not enough for successful drug discovery. In addition to a well-coordinated team effort on the part of dedicated chemists and biologists, success depends on persistence, good decision-making processes, and pure luck.
- Birkhauser Verlag
- Publication date:
- Edition description:
- Softcover reprint of the original 1st ed. 1995
- Product dimensions:
- 6.14(w) x 9.21(h) x 0.67(d)
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