The Search for Anti-Inflammatory Drugs: Case Histories from Concept to Clinic

Overview

This book will be a valuable asset for a medical or university library, as well as for researchers and clinicians. It will make an enticing reading for non-specialists interested in the history behind modern pharmacology, and can be used as a textbook in graduate courses.

The book contains black-and-white illustrations.

Read More Show Less
... See more details below
Paperback (Softcover reprint of the original 1st ed. 1995)
$94.09
BN.com price
(Save 4%)$99.00 List Price
Other sellers (Paperback)
  • All (3) from $91.77   
  • New (3) from $91.77   
Sending request ...

Overview

This book will be a valuable asset for a medical or university library, as well as for researchers and clinicians. It will make an enticing reading for non-specialists interested in the history behind modern pharmacology, and can be used as a textbook in graduate courses.

The book contains black-and-white illustrations.

Read More Show Less

Editorial Reviews

Brian K. Brandley
This book is a collection of nine chapters describing successful drug discovery efforts. As Otterness, at the end of the first chapter, observes: ...Drugs are now targeted extremely specifically against a single mechanism. This greatly reduces the chances of undesired effects. Today the challenge for drug discovery is rarely whether we can develop an inhibitor of a specific mechanism....Can we choose a target mechanism well enough that an inhibitor will have a good probability of being therapeutically effective?... This book may be instructive to those beginning careers in pharmaceutical science and help those already in the trenches recover a view of the larger picture. Based on the histories presented here, all drug candidates meet determined resistance somewhere along their path to approval, and each requires one or more champions to shepherd them through. An introductory historical perspective nicely sets the stage for the chapters that follow. Each chapter serves as an example of one of three approaches to drug discovery. Chapters 2 and 3 demonstrate the utility of screening rnicrobiological extracts for drug candidates or lead molecules. Chapters 4 and 10 describe medicinal chemistry approaches, beginning with known drugs, that seek to improve efficacy, bioavailability, and/or reduce side effects. The remaining chapters describe mechanistic approaches, targeting a receptor or enzyme with lead compounds based on substrates, or discovered from compound library screens. The individual contributions are well written and interesting, providing a sense of the team effort required for success. However, the chapter on cyclosporine is too long and somewhat self-aggrandizing. Readers notintimately involved with the industry may get bogged down in details of the medicinal chemistry and clinical trials in some chapters, and expanded discussion of the decision-making processes would have been welcomed. Still, a careful reader of this book will come away with the message that good science is not enough for successful drug discovery. In addition to a well-coordinated team effort on the part of dedicated chemists and biologists, success depends on persistence, good decision-making processes, and pure luck.
Booknews
Contributes to the history of modern pharmacology by presenting in both a narrative and technical format the actual nature of the discovery or development process for ten anti-inflammatory drugs. Demonstrates to non-specialists and graduate students how concepts are started and how the success or failure of the project emerges from intricate thinking, nuances, prejudices, and scientific and political processes. A companion volume on antiviral drugs is planned. Annotation c. Book News, Inc., Portland, OR (booknews.com)
From The Critics
Reviewer: Brian K. Brandley, PhD (Rush Medical College of Rush University)
Description: This book is a collection of nine chapters describing successful drug discovery efforts.
Purpose: As Otterness, at the end of the first chapter, observes: "...Drugs are now targeted extremely specifically against a single mechanism. This greatly reduces the chances of undesired effects. Today the challenge for drug discovery is rarely whether we can develop an inhibitor of a specific mechanism....Can we choose a target mechanism well enough that an inhibitor will have a good probability of being therapeutically effective?..."
Audience: This book may be instructive to those beginning careers in pharmaceutical science and help those already in the trenches recover a view of the larger picture. Based on the histories presented here, all drug candidates meet determined resistance somewhere along their path to approval, and each requires one or more champions to shepherd them through.
Features: An introductory historical perspective nicely sets the stage for the chapters that follow. Each chapter serves as an example of one of three approaches to drug discovery. Chapters 2 and 3 demonstrate the utility of screening rnicrobiological extracts for drug candidates or lead molecules. Chapters 4 and 10 describe medicinal chemistry approaches, beginning with known drugs, that seek to improve efficacy, bioavailability, and/or reduce side effects. The remaining chapters describe mechanistic approaches, targeting a receptor or enzyme with lead compounds based on substrates, or discovered from compound library screens.
Assessment: The individual contributions are well written and interesting, providing a sense of the team effort required for success. However, the chapter on cyclosporine is too long and somewhat self-aggrandizing. Readers not intimately involved with the industry may get bogged down in details of the medicinal chemistry and clinical trials in some chapters, and expanded discussion of the decision-making processes would have been welcomed. Still, a careful reader of this book will come away with the message that good science is not enough for successful drug discovery. In addition to a well-coordinated team effort on the part of dedicated chemists and biologists, success depends on persistence, good decision-making processes, and pure luck.

3 Stars from Doody
Read More Show Less

Product Details

  • ISBN-13: 9781461598480
  • Publisher: Birkhauser Verlag
  • Publication date: 7/31/2012
  • Edition description: Softcover reprint of the original 1st ed. 1995
  • Edition number: 1
  • Pages: 320
  • Product dimensions: 6.14 (w) x 9.21 (h) x 0.67 (d)

Table of Contents

1 The Discovery of Drugs to Treat Arthritis: A Historical View.- 2 The History of the Discovery and Development of Cyclosporine (Sandimmune®).- 3 Discovery and Development of FK506 (Tacrolimus), A Potent Immunosuppressant of Microbial Origin.- 4 Discovery of Sulindac, a Reversible Prodrug, as a Second-Generation Indomethacin.- 5 The Discovery of Zileuton (Leutrol®).- 6 Discovery of Accolate™ (ICI 204,219), a Peptide Leukotriene Antagonist for Asthma.- 7 Discovery of ZD2138, a Potent, Selective, Well-Tolerated, Nonredox Inhibitor of the Enzyme 5-Lipoxygenase.- 8 Development of MK 0591: An Orally Active Leukotriene Biosynthesis Inhibitor with a Novel Mechanism of Action.- 9 Discovery of BIRM 270: A New Class of Leukotriene Biosynthesis Inhibitors.- 10 Discovery and Development of the Immunomodulatory Azaspiranes.- Keyword Index.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)